A5061180313- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Advanced Glycation End Products research
- Cardiac pacing and defibrillation studies
- Advanced MRI Techniques and Applications
- Cardiovascular Issues in Pregnancy
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Trypanosoma species research and implications
- Cardiac Fibrosis and Remodeling
- Lysosomal Storage Disorders Research
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Long-Term Effects of COVID-19
- Sarcoidosis and Beryllium Toxicity Research
- S100 Proteins and Annexins
- Bone health and osteoporosis research
- Nuclear Receptors and Signaling
- Workplace Health and Well-being
- Apelin-related biomedical research
Istituti di Ricovero e Cura a Carattere Scientifico
2006-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019-2024
Ospedale Maggiore
2019-2024
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2023
University of Milano-Bicocca
2023
University of Milan
2022-2023
University of Cagliari
2022
Chelsea and Westminster Hospital
2020
Imperial College London
2020
University of Parma
2019
Sudden cardiac death (SCD) is the most common mode of in childhood hypertrophic cardiomyopathy (HCM), but there no validated algorithm to identify those at highest risk.
Advanced glycation end-products (AGE) may cause vascular stiffening by forming crosslinks through the collagen molecule or interaction with their cellular transductional receptor (RAGE). A secreted isoform of RAGE, termed soluble RAGE (sRAGE), contribute to removal/detoxification AGE acting as a decoy. Here we studied plasma sRAGE levels in hypertensive and normotensive human subjects. We also investigated relationship between blood pressure parameters concentrations.A cross-sectional...
Implantable cardioverter defibrillators (ICDs) are routinely used to prevent sudden cardiac death (SCD) in selected hypertrophic cardiomyopathy (HCM) patients, but the determinants of device-related complications, therapies and long-term cardiovascular mortality ICD recipients not known.Retrospective observational cohort study.Single-centre tertiary referral clinic. Patients 334 consecutively evaluated HCM patients (median age 40 years, 62% male, 92% primary prevention) at risk SCD treated...
Up to one-half of childhood sarcomeric hypertrophic cardiomyopathy (HCM) presents before the age 12 years, but this patient group has not been systematically characterized. The aim study was describe clinical presentation and natural history patients presenting with nonsyndromic HCM years. Data from International Paediatric Hypertrophic Cardiomyopathy Consortium on 639 children diagnosed younger than years were collected compared those 568 between 16 At baseline, 339 (53.6%) had family...
Aims Levels of the secreted glycophosphoprotein osteopontin (OPN) have been associated with presence and extent coronary artery disease (CAD). The present study assessed relationship between plasma OPN concentrations prognosis in patients chronic stable angina (CSA).
Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder associated with bradyarrhythmias. We sought to examine the nature of conduction system abnormalities and indications determinants anti-bradycardia pacing in patients AFD. studied 204 AFD (49% male, mean age 42 years) observational, longitudinal, retrospective cohort study. At baseline, 5 (2.5%) had pacemakers for treatment bradycardias [4/5 (80%) atrioventricular disease; 1/5 (20%) sinus node disease]. PR interval <120 ms...
The triggers of ventricular arrhythmias (VAs) leading to sudden cardiac death in hypertrophic cardiomyopathy (HCM) are ill defined. We sought examine the electrophysiological characteristics VAs HCM and study their relation phenotype circadian patterns using stored intracardiac electrocardiograms from implantable cardioverter defibrillators (ICDs).A single centre, observational cohort 230 consecutively evaluated ICD recipients with [median age 42 years, 97% primary prevention, 51%...
Background: Maximal left ventricular wall thickness (MLVWT) is a risk factor for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). In adults, the severity of hypertrophy has nonlinear relationship with SCD, but it not known whether same complex seen childhood. The aim this study was to describe between and SCD large international pediatric HCM cohort. Methods: cohort comprised 1075 children (mean age, 10.2 years [±4.4]) diagnosed (1–16 years) from International Paediatric...
The Synergy system, a miniature partial circulatory support device, is implanted by an off-pump, minimally invasive surgical approach. system has been optimized to improve performance in EU clinical trial for chronic ambulatory heart failure. This therefore offers the possibility of treating elderly failure patients who might not usually be considered long-term support.From June 2007 December 2012, 63 were with (12 ≥70 years) using four different releases device. Briefly, draws blood through...
Purpose: Idiopathic pulmonary arterial hypertension (IPAH) prognosis depends on the capability of right ventricle (RV) to preserve its function in face increased afterload.We hypothesize that, as for left ventricle, intra-ventricular (IVD) dyssynchrony may have a negative effect overloaded RV.The aim study was assess IVD by incorporating activation times longitudinal deformation across all RV segments, representing major contribution chamber contraction.Methods: Eighty patients with IPAH (52...
Heart failure (HF) is a multifactorial disorder in which clinical, environmental and genetic components take part. For this reason it possible that common gene variants could affect development, progression response to pharmacological therapy. In recent years the role of AGEs pathogenesis cardiovascular diseases has become recognized but little known about AGE-RAGE system heart failure. The aim present study was identify relationship between -374 T/A RAGE polymorphism with population...
The mechanisms by which migraine is linked to ischemic vascular disease remain uncertain and are likely be complex. aim of this study was investigate the correlation between silent myocardial ischemia (SMI) a history documented primary headache in large population patients with exercise-induced ischemia.The involved 1,427 consecutive (918 symptomatic 509 asymptomatic patients) coronary artery (CAD).Patients anginal symptoms during had significantly higher prevalence than those without (41...
Background: Hypertrophic cardiomyopathy (HCM) is diagnosed according to the presence of morphological and functional traits heart, often in genetic mutations. A specific biomarker assessing aetiopathology this condition lacking. Extracellular vesicles (EVs), small particles released by all cells into biological fluids, hold promise as diagnostic prognostic tools for cardiac diseases. We aim at characterising plasma-derived EVs isolated from 18 consecutive HCM patients 13 healthy volunteers...
Abstract Background Hypertrophic cardiomyopathy (HCM) is a genetic disorder, diagnosed according to the presence of phenotypical traits myocardium. A specific biomarker which can associate with severity HCM lacking. Extracellular Vesicles (EVs), nanoparticles released by cells into biological fluids, hold promise as accessible diagnostic tools, their abundance and molecular composition reflect cardiac diseases (Rizzuto 2024). We aim at characterising plasma-derived EVs isolated from 28...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disease with estimated prevalence of up to 1:5000 in the general population. Few cases ARVC during pregnancy are described literature.A 32-year-old primigravida was referred our clinic 32nd gestational week. diagnosis biventricular involvement made according Task Force criteria. Beta-blocker therapy started and elective caesarean section planned, 37th week; no complications occurred. Thirteen months after delivery,...
Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Italy Correspondence to Dott. Diego Ardissino, ospedaliero-Universitaria Unità operativa Cardiologia, Email: [email protected] Received 5 July, 2016 Accepted 17
Nello scompenso cardiaco (SC), malattia multifattoriale in cui giocano un ruolo diversi fattori, varianti genetiche possono influenzarne lo sviluppo, la progressione e risposta alla terapia farmacologica. Poco si sa circa il del sistema AGE-RAGE nello SC. Al fine di identificare i possibili rapporti tra polimorfismo -374 T/A gene RAGE SC abbiamo quindi arruolato 386 pazienti con sia post-ischemico secondario a causa non ischemica 639 Coronary Artery Disease (CAD). Dalla nostra analisi emerso...
Abstract A 39–year–old Filipino man was admitted for dyspnea and lower limb edema about a month, in combination with stable cardiac enzymes movement (TnT 128&gt;78&gt;115 ng/dl), fluctuating unspecific inflammatory profile hepatic impairment. Trans–thoracic echocardiography confirmed heart failure (HF) setting of eccentric left ventricular hypertrophy, diffuse hypokinesia severe global functionreduction. Despite the absence typical chest pain, presence cardiovascular (CV) risk...
Abstract Objectives Cardiac genetic counselling and testing for inherited cardiomyopathies have become essential aspects of cardiovascular care. A diagnosis in a family can offer an invaluable tool cascade at–risk relatives. careful clinical individualized approach to is now needed guarantee the best care possible. We report results our first–year single–centre experience. Methods From September 2021, 69 tests been carried out at Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milan...
Background Adenosine stress MR shows high sensitivity and intermediate-to-high specificity; therefore, there is a number of false positive patients that referred to useless coronary angiography studies after adenosine MR. We sought verify whether the (semi) quantification amount ischemic myocardium can improve management study. According previous nuclear medicine evidence, we defined 10% LV mass cut-off for diagnosis clinically relevant ischemia. Methods 80 were classified as or negative...
L’infiammazione gioca un ruolo chiave nella aterosclerosi. La galactina-3 e mediatore dell’attivazione dei macrofagi derivato dall’endotelio, attivamente coinvolto regolazione di molti aspetti del comportamento delle cellule infiammatorie. Lo scopo questo studio quello quantificare i livelli plasmatici nei pazienti con malattia coronarica (CAD) le sue diverse manifestazioni cliniche al momento dell’osservazione, per verificare se la potrebbe essere biomarker utile valutazione della...
Apelina e un peptide endogeno che aumenta l’inotropismo cardiaco attraverso l’interazione con il suo recettore APJ. Alcuni risultati indicano sistema apelinergico possa avere ruolo fisiopatologico nell’ambito delle malattie cardiovascolari ci sono prove mostrano del nella regolazione della pressione sanguigna in vitro modelli animali. Il di apelina-APJ fisiologia cardiovascolare la sua interazione altri processi neuroendocrini non stato completamente chiarito. Tuttavia, gli studi riportati...