A5089022449- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Iron Metabolism and Disorders
- Mesenchymal stem cell research
- Retinoids in leukemia and cellular processes
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Blood transfusion and management
- Acute Lymphoblastic Leukemia research
- Long-Term Effects of COVID-19
- Erythrocyte Function and Pathophysiology
- HIV/AIDS Research and Interventions
- Diabetes and associated disorders
- Neutropenia and Cancer Infections
- Organ Transplantation Techniques and Outcomes
- Prenatal Screening and Diagnostics
- Biomedical Ethics and Regulation
- Blood donation and transfusion practices
- Liver Disease and Transplantation
- Diabetes Management and Research
- Hepatitis B Virus Studies
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
Universidade de São Paulo
2015-2024
Clinics Hospital of Ribeirão Preto
2009-2024
Instituto Butantan
2023
Fundação Oswaldo Cruz
2022
Croda (France)
2022
Universidade Federal de Mato Grosso do Sul
2022
São Camilo Hospital
2022
Universidade Federal de São Paulo
2022
Hospital Estadual Centra
2022
Fundação Hemopa
1999-2021
Anemia, neutropenia, and thrombocytopenia are commonly observed in HIV-infected patients. This study was undertaken to evaluate the prevalence of cytopenias their association with CD4 count. Furthermore, hemoglobin concentration mortality also investigated.We reviewed data 701 patients followed at our institution. Blood cell counts, concentration, count, viral load were recorded. We recorded rate after 1 year groups <200/μl ≥ 200/μl according concentration.Of total patients, 37.5% had...
To assess whether high-dose coronavirus disease (COVID-19) convalescent plasma (CCP) transfusion may benefit patients with severe COVID-19, we conducted a multicenter randomized trial in Brazil. Patients COVID-19 who were within 10 days of initial symptom onset eligible. the CCP group received 3 daily doses (600 mL/d) addition to standard treatment; control treatment only. Primary outcomes death rates at 30 and 60 study randomization. Secondary ventilator-free hospital-free days. We enrolled...
CONTEXT AND OBJECTIVES Sickle cell disease (SCD) is the most common genetic disorder among people of African descent, affecting approximately 3,500 newborns each year in Brazil. Hydroxyurea (HU) only effective drug to treating patients with SCD, thereby reducing morbidity and mortality. The objective was analyze effects HU on SCD at our institution. DESIGN SETTING Retrospective study conducted a sickle centre Ribeirão Preto, São Paulo, METHODS We analyzed clinical laboratory data 37...
Differentiation syndrome (DS) represents a life-threatening complication in patients with acute promyelocytic leukemia (APL) undergoing induction therapy all-trans retinoic acid (ATRA) or arsenic trioxide (ATO). It affected about 20-25% of all and so far there are no definitive diagnostic criteria. Clinically, DS is characterized by weight gain, fever not attributable to infection, respiratory distress, cardiac involvement, hypotension, and/or renal failure. At the histological point view,...
Abstract Leukostasis is a relatively uncommon but potentially catastrophic complication of acute myelogenous leukemia (AML). Prompt leukoreduction considered imperative to reduce the high mortality rate in this condition. Leukapheresis, usually associated with chemotherapy, an established approach diminish blast cell counts. We report single center experience managing leukostasis leukapheresis. Fifteen patients 187 AML (8.02%) followed at our institution were treated leukapheresis...
Microparticles (MPs) are present in healthy subjects and their concentration increases patients at high risk of thrombosis. We evaluated 10 with sickle cell anemia (SCA) treated hydroxyurea (HU) 13 SCA without this treatment. MP concentrations were determined by flow cytometry. Coagulation was using the thrombin-antithrombin complex (TAT) D-dimers. Total increased HU-treated group (265 × 10<sup>6</sup>/ml vs. 67.45 10<sup>6</sup>/ml; p = 0.0026), as well MPs derived...
Abstract Background and Aims Over 4 million deaths from coronavirus disease (COVID)‐19 have been reported in the world. Several biomarkers identified that predict severity, but there is still a need to identify for death risk severe COVID‐19. We aim define amongst already those which are mostly associated with increased rate patients Methods In this retrospective study conducted three public hospitals linked Medical School of Ribeirão Preto, Brazil, COVID‐19 were evaluated regarding...
Differentiation Syndrome (DS) is a treatment complication which can occur in patients treated with acute promyelocytic leukemia (APL) all transretinoic acid (ATRA) or As(2)O(3), and characterized by enhanced leukocyte transmigration. Phenylbutyrate (PB) G-CSF are known to potentiate ATRA effects. Our aim was analyze the changes expression function of adhesion molecules induced ATRA, PB, their association.APL blasts NB4 cells were association determined flow cytometry. Cell evaluated vitro...
The objective of this study was to verify the evolution pregnancies in sickle cell patients followed at one institution over a period 12 years (January 2000 June 2012). evaluated 34 pregnant women with disease mean age 23.9 ± 5.3 years. incidence obstetric complications, non-obstetric complications linked and newborn were analyzed. A total 26% cases reported previous miscarriages, 20% had preterm labor, 10% pre-eclampsia, 5% gestational diabetes. Forty-one percent deliveries cesarean...
Intrahepatic cholestasis (SCIC) is an uncommon but potentially fatal complication of sickle cell disease (SCD), with a high death rate, observed mainly in patients homozygous anemia. Herein, we describe case severe SCIC treated successfully aggressive manual exchange transfusion (ET). The patient was admitted enlarged liver and signs hepatic failure, such as hyperbilirubinemia coagulopathy. There no evidence viral hepatitis or biliary obstruction. We performed several sessions ET order to...
Steroid-refractory acute graft-vs.-host disease (SR-aGVHD) is a complication of allogeneic hematopoietic stem cell transplantation with dismal prognosis and for which there no consensus-based second-line therapy. Ruxolitinib not easily accessible in many countries. A possible therapy the administration mesenchymal stromal cells (MSCs).In this retrospective study, 52 patients severe SR-aGVHD were treated MSCs from umbilical cord (UC-MSCs) nine institutions.The median (range) age was 12.5...
Administration of convalescent plasma may serve as an adjunct to supportive treatment prevent COVID-19 progression and death. We aimed evaluate the efficacy safety 2 volumes intravenous (CP) with high antibody titers for severe cases COVID-19. conducted a Bayesian, randomized, open-label, multicenter, controlled clinical trial in 7 Brazilian hospitals. Adults admitted hospital positive RT-PCR SARS-CoV2, within 10 days symptom onset, were eligible. Patients randomly assigned (1:1:1) receive...
Evaluate the impact of ABO histo-blood group type on COVID-19 severity.ABO has been associated with different outcomes in infectious diseases. It also shown a higher proportion A patients SARS-CoV-2. In this observational study, extracted from an ongoing clinical trial efficacy convalescent plasma transfused patients, we describe blood risk developing severe COVID-19.Seventy-two consecutive (37 A, 23 O, 11 B, 1 AB) (respiratory failure) were included. Control was composed 160 individuals...
A 26-year-old woman with sickle cell disease (SCD) on chronic transfusion therapy complained of severe arthralgia, myalgia, abdominal pain, headache, and fever 24 hours after a red blood cells (RBCs). Dengue virus (DENV) infection was suspected the patient hospitalized for clinical support RBC transfusion, to lower hemoglobin S less than 30%. The patient's condition improved approximately 8 days onset symptoms.DENV type 2 (DENV-2) TaqMan real-time polymerase chain reaction negative in...
The therapeutic use of human embryonic stem cells (hESCs) is dependent on an efficient cryopreservation protocol for long-term storage. aim this study was to determine whether the combination three cryoprotecting reagents using two freezing systems might improve hESC recovery rates with maintenance pluripotency properties potential cell therapy application. Recovery colonies which were frozen in cryoprotective solutions: Me2SO/HES/SR medium, Defined-medium® and Me2SO/SFB medium solution...