A5071694251- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin D Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hungarian Social, Economic and Educational Studies
- Sphingolipid Metabolism and Signaling
- Asthma and respiratory diseases
- Immune cells in cancer
- Sleep and Wakefulness Research
- Cancer Treatment and Pharmacology
- Delphi Technique in Research
- Diabetes and associated disorders
- Chronic Myeloid Leukemia Treatments
- Respiratory Support and Mechanisms
- Regional Development and Policy
- Thyroid Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Atherosclerosis and Cardiovascular Diseases
- Gene Regulatory Network Analysis
- Sarcoidosis and Beryllium Toxicity Research
- Exercise and Physiological Responses
- Neuropeptides and Animal Physiology
- Fibroblast Growth Factor Research
- Clusterin in disease pathology
Semmelweis University
2009-2023
PolyGene
2023
Budapest University of Economics and Business
2020
University of Debrecen
2000-2016
University of California, Irvine
2012-2016
UC Irvine Health
2015
Southern California Clinical and Translational Science Institute
2015
Eötvös Loránd University
2009-2013
Rural Development Institute
2012
University of Illinois Chicago
2000-2010
Clinical trials evaluating the management of acute exacerbations COPD assess heterogeneous outcomes, often omitting those that are clinically relevant or more important to patients. We have developed a core outcome set, consensus-based minimum set outcomes we recommend evaluated in all future clinical on management, improve their quality and comparability. were identified through methodological systematic reviews qualitative interviews with 86 patients from 11 countries globally. The most...
Gene regulatory networks are based on simple building blocks such as promoters, transcription factors (TFs) and their binding sites DNA. But how diverse the functions that can be obtained by different arrangements of promoters TF sites? In this work we constructed synthetic regions using promoter elements two noninteracting TFs, each sensing a single environmental input signal. We show simply combining these three kinds elements, obtain 11 16 Boolean logic gates integrate signals in vivo....
Summary The complement system may play a role in the systemic inflammation characterising obstructive sleep apnea; however, this has not been investigated before. We aimed to study involvement of effector elements apnea, namely C3a, C5a and SC 5b‐9. Venous blood was collected 50 patients with apnea 26 control subjects evening following morning. Plasma proteins were analysed ELISA . Complement factor levels compared between two groups correlated clinical variables. C3a concentration elevated...
Watanabe K, Iizuka T, Adeleke A, Pham L, Shlimon AE, Yasin M, Horvath P, Unterman TG. Involvement of toll-like receptor 4 in alveolar bone loss and glucose homeostasis experimental periodontitis. J Periodont Res 2011; 46: 21–30. © 2010 John Wiley & Sons A/S Background Objective: There is general agreement that certain fatty acids lipopolysaccharides (LPS) promote inflammation through (TLR4), promotes insulin resistance. We therefore hypothesized mice with periodontitis a TLR4...
Spingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim this study was to assess potential role circulating S1P anti-ceramide antibody as biomarkers in non-small lung (NSCLC). We recruited 66 subjects (34 controls 32 patients with NSCLC). Patient history clinical variables were taken from all participants. Venous blood samples collected evaluate plasma biomarkers. If...
Obstructive sleep apnoea (OSA) represents a risk for dyslipidaemia. respiratory events during rapid eye movement (REM) are more strongly related to the development of hypertension and diabetes than in non-REM. However, relationship between phases serum lipid profile is unclear. We aimed analyse obstructive REM non-REM as well profile. Polysomnography was performed 94 adult subjects who did not take any lipid-modifying medications. Fasting venous blood sample taken following morning total...
The expression of inducible nitric oxide synthase (NOS2) in glial cells is inhibited by neurotransmitters such as norepinephrine (NE) which elevate cAMP levels. We examined the molecular basis for this effect using a 2.2‐kb fragment rat NOS2 promoter transfected into C6 glioma cells. Promoter activation (up to six‐fold) lipopolysaccharide (LPS) and interferon‐γ (IFNγ) was reduced NE, alone had no effect. However, construct extending bp −130 containing proximal nuclear factor‐kappa B (NF‐κB)...
Next generation sequencing (NGS) is a rapidly developing area in genetics. Utilizing this technology the management of disorders with complex genetic background and not recurrent mutation hot spots can be extremely useful. In study, we applied NGS, namely semiconductor to determine most significant osteogenesis imperfecta-related variants clinical practice. We selected genes coding collagen type I alpha-1 and-2 (COL1A1, COL1A2) which are responsible for more than 90% all cases. CRTAP...
Abstract Purpose Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated role P-selectin vascular OSA. glycoprotein ligand 1 (PSGL-1) main activator for and involved immune cell trafficking. However, PSGL-1 has not been analyzed The aim study was investigate plasma levels have a deeper understanding on their interaction obstructive apnea....
Randomised controlled trials (RCTs) on the management of COPD exacerbations evaluate heterogeneous outcomes, often omitting those that are clinically important and patient relevant. This limits their usability comparability. A core outcome set (COS) is a consensus-based minimum outcomes should be evaluated in all RCTs specific areas health care. We present study protocol COS-AECOPD ERS Task Force, aiming to develop COS for exacerbation management, could remedy these limitations. For...
Expression of inflammatory nitric oxide synthase (NOS2) is mediated by transcription factor NFkappaB. By using the specific proteasome inhibitor lactacystin to examine IkappaB degradation, we observed a paradoxical increase in lipopolysaccharide- and cytokine-dependent NOS2 expression at low concentrations or when was added subsequent cytokines. Lactacystin reduced initial accumulation mRNA but its decrease. increased promoter activation after 24 h, not 4 similarly prevented NFkappaB later...
Objective. Wilson's disease is a disorder of copper metabolism which fatal without treatment. The great number disease-causing ATP7B gene mutations and the variable clinical presentation WD may cause real diagnostic challenge. emergence next-generation sequencing provides time-saving, cost-effective method for full whole compared to traditional Sanger sequencing. This first report on use NGS examine gene. Materials Methods. We used Ion Torrent Personal Genome Machine in four heterozygous...
In the natural environment, bacterial cells have to adjust their metabolism alterations in availability of food sources. The order and timing gene expression are crucial these situations produce an appropriate response. We used galactose regulation Escherichia coli as a model system for understanding how integrate information about cAMP levels intensity expression. simulated feast-famine cycle growth by diluting stationary phase fresh medium containing sole carbon source. followed activities...
Introduction Cardiovascular complications are the leading cause of mortality in type 2 diabetes (T2DM), which onset and progression atherosclerosis is linked to chronic inflammation. Activation status innate immune cells (granulocytes [Gc], monocytes [Mc]), as reflected by increased CD11b, CD66b, other surface markers, increases their endothelial cytokines/chemokines release. Whereas this inflammatory activation seems inversely related poor glycemic control, effect acute spontaneous...
ABSTRACT Many transcription factors repress of their own genes. Negative autoregulation has been shown to reduce cell-cell variation in regulatory protein levels and speed up the response time gene networks. In this work we examined regulation galS function its product, GalS protein. We observed a unique operator preference characterized by dominant negative autoregulation. show that pattern limits repression level target genes steady states. suggest with are designed for regulating...
Objective: Extended nitric oxide (NO) analysis offers the partitioned monitoring of inflammation in central and peripheral airways. Different mathematical models are used to estimate pulmonary NO dynamics asthma with variable results limitations. We aimed establish a protocol for extended patients differing severity. Methods: Forty stable 25 matched control subjects were recruited. Exhaled was measured at constant flow rates between 10 300 mL/s. Twelve controls performed measurements weekly...
Atherosclerosis/cardiovascular disease are major causes of morbidity/mortality in obesity and type 2 diabetes (T2D), have been associated with activation innate immune cells, their diapedesis to the arterial intima formation atherosclerotic plaque. While obesity/T2D cell likely depends on dysregulated metabolism, interaction between individual metabolic factors typical these conditions (hyperglycemia, hyperlipidemia), activation, progression atherosclerosis remains unclear. We, therefore,...
Diagnosing interstitial lung disease (ILD) can be a challenging process. New biomarkers may support diagnostic decisions. Elevated serum progranulin (PGRN) levels have been reported in liver fibrosis and dermatomyositis-associated acute pneumonia. Our aim was to assess the role of PGRN differential diagnosis idiopathic pulmonary (IPF) other ILDs. Serum were measured by enzyme-linked immunosorbent assay stable IPF (n = 40), non-IPF ILD 48) healthy controls 17). Patient characteristics,...
Type I diabetes is associated with a low incidence of asthma. We tested whether decrease in sensory neuropeptide release an attenuated bronchoconstrictive response to field stimulation (FS; 100 stimuli, 20 V, 0.1 ms, Hz) streptozotocin (STZ)-induced diabetes. The organ fluid the preparations were also for substance P, calcitonin gene-related peptide (CGRP), and somatostatin concentrations by RIA. Preparations from either normal rats or those pretreated 50 mg/kg STZ iv 8 wk before experiment....