A5052485452- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Plant Molecular Biology Research
- Microtubule and mitosis dynamics
- Plant Reproductive Biology
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Photosynthetic Processes and Mechanisms
- Cardiac pacing and defibrillation studies
- Hormonal Regulation and Hypertension
- Glycosylation and Glycoproteins Research
- Plant nutrient uptake and metabolism
- Advanced MRI Techniques and Applications
- Exercise and Physiological Responses
- Cardiac Imaging and Diagnostics
- Autophagy in Disease and Therapy
- Cardiovascular Effects of Exercise
- Sirtuins and Resveratrol in Medicine
- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Metabolism and Genetic Disorders
Northwestern Polytechnical University
2018-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2022
Fudan University
2022
Zhongshan Hospital
2022
Air Force Medical University
2014-2021
Hainan University
2021
China Agricultural University
2009-2016
University of Minnesota
2012
Rationale: Exercise training, in addition to reducing cardiovascular risk factors, confers direct protection against myocardial ischemia/reperfusion injury and has been associated with improved heart attack survival humans. However, the underlying mechanisms of exercise-afforded cardioprotection are still unclear. Objective: To investigate role exercise-derived circulating exosomes molecular involved. Methods Results: Circulating were isolated from plasma volunteers or without exercise...
Heart failure (HF) is characterized by reduced fatty acid (FA) utilization associated with mitochondrial dysfunction. Recent evidence has shown that enhancing FA may provide cardioprotection against HF. Our aim was to investigate the effects and underlying mechanisms of cardiac on function in response pressure overload. Transverse aortic constriction (TAC) used C57 mice establish overload-induced TAC fed a high fat diet (HFD) exhibited increased improved survival compared those control diet....
Many biological processes require the co-operative involvement of both microtubules and microfilaments; however, only a few proteins mediating interaction between microfilaments have been identified from plants. In present study, cotton kinesin GhKCH2, which contains CH (calponin homology) domain at N-terminus, was analysed in vitro vivo order to understand its with two cytoskeletal elements. A specific antibody against GhKCH2 prepared used for immunolabelling experiments. Some spots...
Abstract The involvement of cytoskeleton-related proteins in regulating mitochondrial respiration has been revealed mammalian cells. However, it is unclear if there a relationship between the microtubule-based motor protein kinesin and respiration. In this research, we demonstrate that plant-specific kinesin, Kinesin-like 1 (KP1; At KIN14 h), involved respiratory regulation during seed germination at low temperature. Using vitro biochemical methods vivo transgenic cell observations, KP1 able...
Moderate exercise decreases the risk for atrial fibrillation (AF), an effect which is probably mediated via exercise-stimulated release of exerkines. β-Aminoisobutyric acid (BAIBA), a novel exerkine, has been reported to provide protective benefits against many cardiovascular diseases, yet its role in AF remains elusive. Herein, using mouse model obesity-related through high-fat diet (HFD) feeding, we found that 12-week drinking administration BAIBA (170 mg/kg/day) decreased susceptibility...
Abstract Atrial fibrillation (AF) is an increasingly prevalent arrhythmia with significant health and socioeconomic impact. The underlying mechanism of AF still not well understood. In this study, we sought to identify hub genes involved in AF, explored their functions mechanisms based on bioinformatics analysis. Five microarray datasets GEO were used the differentially expressed (DEGs) by Robust Rank Aggregation (RRA), screened out using protein–protein interaction (PPI) network. model was...
Abstract Necroptosis, a novel programmed cell death, plays critical role in the development of fibrosis, yet its atrial fibrillation (AF) remains elusive. Mounting evidence demonstrates that aerobic exercise improves AF‐related symptoms and quality life. Therefore, we explored necroptosis AF pathogenesis exercise‐conferred cardioprotection. A mouse model was established either by calcium chloride acetylcholine (CaCl 2 ‐Ach) administration for 3 weeks or high‐fat diet (HFD) feeding 12 weeks,...
Atrial fibrillation (AF) is the most common tachyarrhythmia in urgent need of therapeutic optimization. Obesity engenders AF, and its pathogenesis closely intertwined with insulin resistance (IR), but mechanism-based management still underinvestigated. Intermittent fasting (IF) a novel lifestyle intervention that mitigates IR, potential AF driver, yet whether IF can prevent obesity-related remains elusive. Here, we aimed to evaluate impacts short-term on uncover underlying mechanism.We...
Gluconolactone (D-glucono-1,5-lactone or GDL) is a food additive which presents in dietary products such as tofu, yogurt, cheese, bread, wine, etc. GDL has long been considered free radical scavenger; however, its role cardioprotection remains elusive. In this study, using mouse model of myocardial ischemia/reperfusion (I/R) injury and hypoxia/reoxygenation (H/R) neonatal rat cardiomyocytes (NRCM), we explored the I/R injury. We found that (5 mg/kg, i.p.) attenuated evidenced by decreased...
Abstract Melatonin has been proven to have antiarrhythmic potential; however, several studies recently challenged this view. Herein, using a mouse model of obesity‐induced atrial fibrillation (AF), we tentatively explored whether exogenous melatonin supplementation could increase AF susceptibility in the context obesity. We observed that an 8‐week drinking administration (60 µg/ml water) induced greater obese mice, although structural remodeling was alleviated. An investigation systemic...
Myocardial reperfusion decreases glucose oxidation and uncouples from glycolysis. Therapies that increase lessen myocardial ischemia-reperfusion (I/R) injury. However, the regulation of uptake during remains poorly understood. We found was remarkably diminished in myocardium following Sprague-Dawley rats as detected by 18 F–labeled fluorescent-labeled analogs, even though GLUT1 upregulated threefold GLUT4 translocation remained unchanged compared with those sham-treated rats. The decreased...
In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- micro-particles including biological cells with advantages label-free, high sensitivity accuracy. this letter, we introduce a novel tilted-angle SAW to optimise pressure inside microchannel for cancer-cell manipulation. The generation radiation force are improved by seamlessly patterning electrodes space surrounding microchannel. Comparisons between...
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical setting. Its pathogenesis was associated with metabolic disorder, especially defective fatty acids oxidation (FAO). However, whether promoting FAO could prevent AF occurrence and development remains elusive. In this study, we established a mouse model of obesity-related through high-fat diet (HFD) feeding, used l-carnitine (LCA, 150 mg/kg⋅BW/d), an endogenous cofactor carnitine palmitoyl-transferase-1B...
The progression of myocardial injury secondary to hypertension is a complex process related series physiological and molecular factors including oxidative stress. This study aimed investigate whether moderate-intensity exercise (MIE) could improve cardiac function stress in spontaneously hypertensive rats (SHRs). Eight-week-old male SHRs age-matched Wistar-Kyoto were randomly assigned training (treadmill running at speed 20 m/min for 1 h continuously) or kept sedentary 16 weeks. Cardiac was...
Acute hyperglycemia is regarded as a risk factor for critically ill patients; however, insufficient understanding of its nature and underlying mechanisms hinders widespread adoption glycemic control in critical care units.A single center, prospective cohort study recruiting 107 burn patients 62 controls was conducted to characterize the early phase acute patients. A total 1643 blood samples were collected analyzed over entire postburn 200 h. mouse severe model used postburn.The dynamic...