A5075027564- Ferroptosis and cancer prognosis
- Heat shock proteins research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Immune cells in cancer
- Influenza Virus Research Studies
- Autophagy in Disease and Therapy
- Respiratory viral infections research
- Clusterin in disease pathology
- FOXO transcription factor regulation
- thermodynamics and calorimetric analyses
- Galectins and Cancer Biology
- Cancer-related cognitive impairment studies
- Social and Intergroup Psychology
- S100 Proteins and Annexins
- Single-cell and spatial transcriptomics
- Fibroblast Growth Factor Research
- Gene Regulatory Network Analysis
- Animal Disease Management and Epidemiology
- Cancer, Stress, Anesthesia, and Immune Response
Weizmann Institute of Science
2020-2025
Israel Ministry of Health
2017-2018
Tel Aviv University
2015-2017
Significance Sex/gender differences in the brain are of high social interest because their presence is typically assumed to prove that humans belong two distinct categories not only terms genitalia, and thus justify differential treatment males females. Here we show that, although there sex/gender behavior, human brains comprised unique “mosaics” features, some more common females compared with males, females, both males. Our results demonstrate regardless cause observed behavior (nature or...
Abstract The tumor microenvironment (TME) is comprised of non-malignant cells that interact with each other and cancer cells, critically impacting biology. TME complex, understanding it requires simplifying approaches. Here we provide an experimental-mathematical approach to decompose the into small circuits interacting cell types. We find, using female breast single-cell-RNA-sequencing data, a hierarchical network interactions, cancer-associated fibroblasts (CAFs) at top secreting factors...
Abstract In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC) in patients with inflammatory bowel disease. While causal and clinical links are well established, molecular understanding of how leads development is lacking. Here we deconstruct evolving microenvironment CAC by measuring proteomic changes extracellular matrix (ECM) organization over time a mouse model CAC. We detect early ECM structure composition, report crucial role for...
Gastric cancer is the third most lethal worldwide, and evaluation of genomic status gastric cells has not translated into effective prognostic or therapeutic strategies. We therefore hypothesize that outcomes may depend on tumor microenvironment (TME), in particular, cancer-associated fibroblasts (CAF). However, very little known about role CAFs cancer. To address this, we mapped transcriptional landscape human stroma by microdissection RNA sequencing from patients with A stromal gene...
Abstract Tumors initiate by mutations in cancer cells, and progress through interactions of the cells with non-malignant tumor microenvironment. Major players microenvironment are cancer-associated fibroblasts (CAFs), which support malignancy, comprise up to 90% mass pancreatic cancer. CAFs transcriptionally rewired cells. Whether this rewiring is differentially affected different largely unknown. Here we address question dissecting stromal landscape BRCA -mutated Wild-type ductal...
Abstract Cancer cells recruit and rewire normal fibroblasts in their microenvironment to become protumorigenic cancer-associated (CAF). These CAFs are genomically stable, yet transcriptional programs distinct from those of counterparts. Transcriptional regulation plays a major role this reprogramming, but the extent which epigenetic modifications DNA also contribute rewiring CAF transcription is not clear. Here we address question by dissecting landscape breast CAFs. Applying...
Cancer-associated fibroblasts (CAFs) are abundant components of the breast tumor microenvironment and major contributors to immune-modulation. CAFs regulate activity many immune cells including T-cells, macrophages dendritic cells, however little is known about their interaction with natural killer (NK) which constitute an important arm anti-tumor immunity. Using mouse models cancer ex-vivo co-cultures, we find that inhibit NK cell cytotoxicity towards cells. We unravel mechanism by...
The 2016-2017 influenza season in Israel was dominated by the circulation of A(H3N2). Influenza vaccine is recommended for entire population aged >6 months. inactivated chosen use this season.We estimated end-of-season effectiveness (VE) preventing influenza-like illness due to A(H3N2), using test-negative design. Age-specific VE a moving age window and weekly analysis.During season, 1267 samples were collected; 467 (36.9%) positive influenza, with 97.9% 0.2% A(H1N1)pdm09, 1.9% B. A total...
IntroductionInfluenza vaccine is recommended for the entire population in Israel. We assessed influenza effectiveness (VE) 2014/15 and 2015/16 seasons Israel, first time. Methods: Combined nose throat swab specimens were collected from patients with influenza-like illness (ILI) presenting to sentinel primary care clinics tested virus by RT-PCR. VE of trivalent inactivated (TIV) was using test-negative case-control design. Results: During season 1,142 samples collected; 327 (28.6%) positive...
// Nehemya Friedman 1, 2, * , Yaron Drori Rakefet Pando 3 Aharona Glatman-Freedman 3, 4 Hanna Sefty Ravit Bassal Yaniv Stein Tamy Shohat Ella Mendelson 2 Musa Hindiyeh Michal Mandelboim 1 Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Ramat-Gan, Israel Department Epidemiology and Preventive Medicine, School Public Sackler Faculty Tel-Aviv University, Tel-Aviv, The Center for Disease Control, Tel-Hashomer, Departments Pediatrics Family Community Valhalla, New...
Abstract Tumors are supported by cancer-associated fibroblasts (CAFs). CAFs heterogeneous and carry out distinct functions. Understanding the full repertoire of their dynamic changes could improve precision cancer treatment. usually analyzed at a single time-point using specific markers, it is therefore unclear whether display plasticity as tumors evolve. Here, we analyze thousands index transcriptional single-cell sorting, several time-points along breast tumor progression in mice,...
Abstract Cancer associated fibroblasts (CAFs) are among the most abundant components of breast tumor microenvironment (TME) and major contributors to immune modulation. CAFs well-known regulate activity diverse types cells including T cells, macrophages dendritic however little is known about their interaction with Natural killer (NK) which constitute an important arm anti-tumor immunity. Here we find, using mouse models cancer ex-vivo co-cultures, that inhibit NK cell cytotoxicity towards...
Abstract The tumor microenvironment (TME) is composed of various nonmalignant cell types that interact with each other and cancer cells, impacting all aspects biology. TME complex heterogeneous, thus simplifying systems concepts are needed. Here we provide a tractable experimental system powerful mathematical circuit to identify the main molecular interactions govern composition TME. We focus on two major components - associated fibroblasts (CAFs) macrophages (TAMs), define their verify our...
Influenza-related morbidity impacts healthcare systems, including hospitals.To obtain a quantitative assessment of hospitalization burden in pediatric and internal medicine departments during influenza seasons compared with the summer months Israel.Data on hospitalized patients general hospitals Israel between 2005 2013 were analyzed for rate hospitalizations, days, hospital length stay (LOS), bed occupancy months. Data hospitalizations all diagnoses, diagnoses respiratory or cardiovascular...
<div>Abstract<p>Cancer cells recruit and rewire normal fibroblasts in their microenvironment to become protumorigenic cancer-associated (CAF). These CAFs are genomically stable, yet transcriptional programs distinct from those of counterparts. Transcriptional regulation plays a major role this reprogramming, but the extent which epigenetic modifications DNA also contribute rewiring CAF transcription is not clear. Here we address question by dissecting landscape breast CAFs....
<p>This file contains Supplementary Materials and Methods, Figure Legends, 6 Figures with their legends</p>
<div>Abstract<p>Cancer cells recruit and rewire normal fibroblasts in their microenvironment to become protumorigenic cancer-associated (CAF). These CAFs are genomically stable, yet transcriptional programs distinct from those of counterparts. Transcriptional regulation plays a major role this reprogramming, but the extent which epigenetic modifications DNA also contribute rewiring CAF transcription is not clear. Here we address question by dissecting landscape breast CAFs....
<div>Abstract<p>Gastric cancer is the third most lethal worldwide, and evaluation of genomic status gastric cells has not translated into effective prognostic or therapeutic strategies. We therefore hypothesize that outcomes may depend on tumor microenvironment (TME), in particular, cancer-associated fibroblasts (CAF). However, very little known about role CAFs cancer. To address this, we mapped transcriptional landscape human stroma by microdissection RNA sequencing from...