A5009667292- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Renal and related cancers
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- Multiple Myeloma Research and Treatments
- Pluripotent Stem Cells Research
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Neonatal Respiratory Health Research
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Signaling Pathways in Disease
- Chemokine receptors and signaling
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Macrophage Migration Inhibitory Factor
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
Weizmann Institute of Science
2010-2022
p53 deficiency enhances the efficiency of somatic cell reprogramming to a pluripotent state. As is usually mutated in human tumors and many forms gain novel activities, we studied influence mutant (mut-p53) on reprogramming. Our data indicate function (GOF) property for mut-p53, which markedly enhanced process compared with deficiency. Importantly, this activity mut-p53 induced alterations characteristics reprogrammed cells. Although knockout (KO) cells only Oct4 Sox2 maintained their...
Significance CD74 has been associated with tumor progression and metastasis. Its expression suggested to serve as a prognostic factor in many cancers, higher relative behaving marker of progression. Our previous studies showed that stimulation expressed on chronic lymphocytic cells initiates signaling cascade leading survival. The present study demonstrates CD74’s cytoplasmic domain binds chromatin regulates transcription genes involved immune regulation, cell survival, hematopoietic...
Cell differentiation is directed by signals driving progenitors into specialized cell types. This process can involve collective decision-making, when differentiating cells determine their lineage choice interacting with each other. We used live-cell imaging in microwell arrays to study processes affecting of naïve CD4+ T memory precursors. found that precursor sharply increases above a threshold number locally cells. These homotypic interactions the cytokines interleukin-2 (IL-2) and IL-6,...
The p53 tumor suppressor coordinates a multitude of cellular and organismal processes exerts its activities mainly by activation gene transcription. Here we describe the transcriptional ectodysplasin A2 receptor ( EDA2R ) in variety cell types tissues. We demonstrate that treatment cancer cells with ligand EDA‐A2, known to specifically activate EDA2R, results p53‐dependent death. Moreover, show is transactivated during chemotherapy‐induced hair‐loss, although presence not necessary for this...
The transcription factor p53 functions not only to suppress tumorigenesis but also maintain normal development and homeostasis.Although was implicated in different aspects of fertility, including spermatogenesis implantation, the mechanism underlying involvement is poorly resolved.In this study we describe identification a spermatogenesis-associated gene, SPATA18, as novel transcriptional target show that SPATA18 induced by variety cell types both human mouse origin.p53 binds consensus DNA...
The glucocorticoid receptor (GR) acts as a ubiquitous cortisol-dependent transcription factor (TF). To identify co-factors, we used protein-fragment complementation assays and found that GR recognizes FLI1 additional ETS family proteins, TFs relaying proliferation and/or migration signals. Following steroid-dependent translocation of to the nucleus, FLI1-specific domain (FLS) binds with strongly enhances GR's transcriptional activity. This interaction has functional consequences in Ewing...
Abstract Tumors are supported by cancer-associated fibroblasts (CAFs). CAFs heterogeneous and carry out distinct functions. Understanding the full repertoire of their dynamic changes could improve precision cancer treatment. usually analyzed at a single time-point using specific markers, it is therefore unclear whether display plasticity as tumors evolve. Here, we analyze thousands index transcriptional single-cell sorting, several time-points along breast tumor progression in mice,...
Abstract Cancer associated fibroblasts (CAFs) are prevalent in carcinomas. CAFs also heterogeneous and perform various tumor-promoting tasks. Understanding whether distinct CAF-subsets exert specific functions, how the composition of changes as tumors evolve could improve accuracy cancer treatment. Here, we analyzed thousands by single-cell RNA-sequencing index-sorting at several timepoints along breast tumor progression mice, revealing CAF-subsets. We discovered that transcriptional...