A5084650353- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Mast cells and histamine
- ATP Synthase and ATPases Research
- Allergic Rhinitis and Sensitization
- Gut microbiota and health
- Ion channel regulation and function
- Sinusitis and nasal conditions
- Oral microbiology and periodontitis research
- Glycosylation and Glycoproteins Research
- Respiratory and Cough-Related Research
- Drug-Induced Adverse Reactions
Chungnam National University Hospital
2020
Pohang University of Science and Technology
1999-2013
Johns Hopkins University
2010
Seoul National University
2006
To cite this article: Hong S-W, Kim M-R, Lee E-Y, JH, Y-S, Jeon SG, Yang J-M, B-J, Pyun B-Y, Gho YS, Y-K. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy 2011; 66: 351–359. Background: Recently, we found that produces extracellular (EV) contain pathogenic proteins. Although S. infection has been linked with dermatitis (AD), the identities of causative agents are controversial. We evaluated whether aureus-derived EV causally...
To improve understanding of aspirin hypersensitivity, this study focused on adenosine as a noncyclooxygenase target molecule aspirin. Adenosine may affect the release histamine from cutaneous mast cells through mechanism mediated by A3 receptor.To investigate genetic contribution receptor gene (ADORA3) polymorphisms in pathogenesis aspirin-induced urticaria (AIU) case-control association Korean population.A was performed 385 patients with AIU and 213 normal controls population. The...
The biological activity of deer antler has been considered to originate in the gangliosides, although structures gangliosides have not well elucidated. quality as an Asian folk medicine often evaluated by amount contained crude drug. We completed structural determination five isolated from present study.Five ganglioside fractions were and purified antler, Cervus nippon, Folch-Suzukipartition method, DEAE-Sephadex A-25, further silica gel column chromatography. High field proton nuclear...
Cite this as: S. Y. Oh, J.-U. Park, T. Zheng, Y.-K. Kim, F. Wu, H. Cho, D. Barber, J. Penninger and Z. Zhu, Clinical & Experimental Allergy, 2011 (41) 434–442. Summary Background As an E3 ubiquitin ligase a molecular adaptor, Cbl-b controls the activation threshold of antigen receptor negatively regulates CD28 costimulation, functioning as intrinsic mediator T cell anergy that maintains tolerance. However, role in airway immune response to aeroallergens is unclear. Objective To determine...
Atopy is considered to be a complex genetic trait and does not follow simple mendelian pattern of inheritance. It now well recognised that gene-gene interactions are important in disease.To analyse the influence development atopy.A total 2055 ethnically identical participants aged 10-18 years living rural areas on Jeju Island, Korea, were randomly recruited. was defined as positive skin prick test response one or more common inhalant allergens. Gene-gene among 12 polymorphic loci analysed...
Treatment with angiotensin-converting enzyme (ACE) inhibitors can induce chronic cough in many patients. Genetic variations the neurokinin 2 receptor gene (NK2R) are significantly associated sensitivity to capsaicin.This study assessed relationship between genetic polymorphisms NK2R and 91 patients taking ACE inhibitors. Patients included did not have chest abnormalities, postnasal drip, gastroesophageal reflux or a recent history of upper respiratory infection.We detected two single...
Background Recent evidence indicates that TNF-α is a key mediator of the development dsRNA-enhanced Th2 cell response to inhaled allergens. Natural killer T (NKT) cells may be candidate source Th2-polarizing cytokines. Objective The objective this study was evaluate role lung NKT on TNF-α-mediated response. Methods A virus-associated asthma mouse model generated by administration ovalbumin (OVA, 75 μg) and poly[I:C] (0.1 μg). Role type I evaluated using CD1d- Jα18-deficient mice. receptors...
Abstract Background Antibiotics are commonly prescribed to treat chronic rhinosinusitis (CRS); however, the effects of antibiotics on microbiome and secreted proteome remain unknown in regard CRS. Objective We analyzed nasal context CRS using multi-omic analysis. Methods Nasal secretions were collected from 29 control, 30 patients without polyps (CRSsNP), 40 with (CRSwNP). A total 99 subjects divided into two groups that included who had taken 3 months prior sampling (ABX) those not (NABX)....