A5091567495- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Photodynamic Therapy Research Studies
- Esophageal and GI Pathology
- Inflammatory mediators and NSAID effects
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Mycobacterium research and diagnosis
- Colorectal Cancer Treatments and Studies
- Diverticular Disease and Complications
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
Juntendo University Hospital
2014-2020
Juntendo University
2010-2019
Istanbul University-Cerrahpaşa
2014
Turkish Society of Hematology
2014
Osaka University
1987-2004
Ontario Institute for Cancer Research
2001
University Gastroenterology
1999
Kyoto Prefectural University of Medicine
1995
Osaka University Hospital
1990
Kyowa Kirin (Japan)
1989
Objective. It is proposed that Fusobacterium varium might be one of the elusive pathogenic factors in ulcerative colitis (UC). Our goal was to assess whether an antibiotic combination therapy against F. effective for induction and maintenance remission UC. Material methods. Twenty chronic, active UC patients with infection were enrolled consecutively randomly assigned receive amoxicillin, tetracycline or metronidazole per os 2 weeks (treatment group; n=10), no antibiotics (control n=10)....
This study evaluated inter- and intraobserver agreement in the assessment of ulcerative colitis (UC) activity using 4 established indices a newly designed Modified 6-point Activity Index. In all, 279 endoscopic pictures inflammatory lesions from 93 UC patients were displayed twice to expert trainee endoscopists, at an interval 1 month. Each picture was assessed for changes (Matts, Schroeder [a.k.a. Mayo Score], Baron, Blackstone) our new Weighted kappa statistics used estimate intra-...
OBJECTIVES: Studies in the US and Europe have shown that appendectomy may prevent development of ulcerative colitis, but no detailed study has been conducted Japan, where colitis is uncommon population racially homogeneous. In addition, there analysis relationship between clinical course colitis. this multicenter study, we evaluated effects on Japan. METHODS: A case-control was undertaken seven medical institutions comparing incidence tonsillectomy 325 patients with controls matched for age...
Endoscopic submucosal dissection (ESD) is a recently developed technique, but it not widely used to treat the colorectum because of its degree technical difficulty. It possible that traction lesion may facilitate correct visualization and make easier dissect. Several techniques involving have been reported [1] [2] [3] [4]. However, these methods employed date due difficulty in both fit ease use. We therefore designed new device, "S-O clip (Sakamoto-Osada clip)", for ESD.
Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are indicated for the treatment of large early-stage superficial colorectal cancers. Bleeding perforation common complications EMR ESD, but closure defect reduces risk complications. Hemoclips have been used defects, they can only be when diameter is less than width open clip. Because it quite difficult to do, not close defects despite increased bleeding perforation. A few techniques involving devices reported [1]...
Summary Background : We proposed that Fusobacterium varium is one of the causative agents in ulcerative colitis. Aim To examine efficacy antibiotic combination therapy against F. and to investigate mucosa‐associated bacteria before after using a new molecular approach. Methods Twenty patients with colitis were randomly assigned into treatment group (amoxicillin, tetracycline metronidazole for 2 weeks) no‐antibiotics group. Clinical assessment, colonoscopic histological evaluations performed...
OBJECTIVE: Increased knowledge of the significance Helicobacter pylori (H. pylori) infection in gastric disorders has accelerated trend screening patients with dyspepsia for its infection. Serological examination antibody H. been widely performed. Recently, a urine-based enzyme-linked immunosorbent assay (URINELISA) kit detection developed. Accordingly, we evaluated diagnostic accuracy clinical practice. METHODS: Subjects this study were 132 who presented at our university hospital because...
Both glucagon and glucagon-like peptide-1 (GLP-1) play an important role in the regulation of nutrient homeostasis. In this study, tissue distributions expression receptor genes for GLP-1 were examined. Expression gene was detected liver, kidney, ileum pancreatic islets but not brain. contrast, brain, pancreas or ileum. To investigate existence characteristics receptors on β cells, translational by glucose analyzed a mouse cell line, MIN6 cells. cDNA pool both identified showed higher level...
Summary Background : A decrease in pepsinogen and gastrin levels 1–3 months after Helicobacter pylori eradication is well known. However, few data are available on the long‐term progression of these decreases beyond 1 year eradication, there has been no investigation into whether return to normal as defined by from H. ‐negative patients with dyspepsia. Aim We studied effect for more than year, compared those also investigated course atrophic corpus gastritis reflected histology, PGI PG I/II...
Objective Capsule endoscopy (CE) allows direct examination of the small bowel in a safe, noninvasive and well-tolerated manner. Nonetheless, experience indicates failure to reach cecum 20-30% patients within 8 hour battery life. Attempts improve completion rate (CR) as defined by reaching have been unsuccessful. This study was investigate relationship between patients' physical activity CR. Methods Between January 2009 2010, 76 (44 men, 32 women; median age 64.5 yr) underwent CE for...
Although various traction devices exist for endoscopic submucosal dissection (ESD), the effects of material used in on human body has not been considered. Moreover, there no report a device that facilitates both oral and anal side lesion. We made deleterious is noninvasive, easy to use, enables bilateral approach ESD. process its creation prospective evaluation usage actual ESD procedures. This study case control study. Thirty-seven patients whom would be were consecutively prospectively...
Background: Gastric blood circulation maintains the structure and functions of stomach, thereby is closely associated with pathogenesis healing gastrointestinal lesions. mucosal flow, regulated by systemic neural humoral factors, also modified local metabolic factors such as prostaglandins, leukotrienes, PAF other endogenous chemical mediators in mucosa. Endothelium-derived that are produced vascular endothelial cells, inducing relaxation or contraction vessels, recognized basic regulate...
Malignant tumors generate autofluorescent patterns that differ from those of normal tissue. However, whether diagnosis could be genuinely useful in screening for gastric neoplasms has not been well investigated clinical practice. Accordingly, we retrospectively studied our experience with this diagnostic technique various lesions and assessed its utility.Autofluorescence 109 79 patients was done, without knowledge the by conventional white light endoscopy, independently three endoscopists 6...
OBJECTIVE: Increased knowledge of the significance Helicobacter pylori (H. pylori) infection in gastric disorders has accelerated trend screening patients with dyspepsia for its infection. Serological examination antibody H. been widely performed. Recently, a urine-based enzyme-linked immunosorbent assay (URINELISA) kit detection developed. Accordingly, we evaluated diagnostic accuracy clinical practice. METHODS: Subjects this study were 132 who presented at our university hospital because...
Capsule endoscopy (CE) is an established technique for the detection and diagnosis of obscure gastrointestinal bleeding (OGIB). Flexible spectral imaging color enhancement (FICE) a software feature RAPID 6.5. This study assessed value FICE accurate identification red lesions during CE.We randomly selected 10 patients who underwent CE OGIB at Juntendo University. The images were read by five endoscopists. Small bowel videos, which recorded regular devices (PillCam SB2, Given Imaging),...
Background: Previously, we reported that most gastrointestinal tumors could be distinguished with the Light‐Induced Fluorescence Endoscopy for GastroIntestine system (LIFE‐GI system) using a fiberscope. However, quality of fiberscopic images was inferior compared videoscopic images. Therefore, developed new Auto‐Fluorescence Imaging (AFI) videoscope (manufactured by Olympus Corp.). Methods: We evaluated clinical usefulness AFI detection colonic neoplasms. Using this system, observed 168...
The incidence of ischemic colitis (IC) in Japan has been increasing due to the westernization diet and aging population. aim this study was evaluate relationship between endoscopic findings clinical severity IC.This retrospective analysis included 106 cases diagnosed with IC that were divided into two groups based on acute stage: redness erosion (RE) versus longitudinal circumferential ulcers (LCU). variables compared groups. In addition, we investigated risk factors associated by...
Aim . To examine optimal timing for resuming antithrombotic agents and risk factors delayed bleeding after endoscopic resection of colorectal tumors. Method Of 1,970 polyps larger than 10 mm removed by polypectomy, mucosal resection, or submucosal dissection, bleeding, which was designated as that occurred 6 more hours treatment, in 52 cases (2.6%); 156 nonbleeding matched age gender were controls this single-institution retrospective case-control study. We investigated (1) patient-factors:...