A5101449725- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA regulation and disease
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- Bacteriophages and microbial interactions
- Metal Extraction and Bioleaching
- RNA modifications and cancer
- Microbial Metabolism and Applications
- Epigenetics and DNA Methylation
- Protein Interaction Studies and Fluorescence Analysis
- Drug Transport and Resistance Mechanisms
- Microtubule and mitosis dynamics
- Genetic factors in colorectal cancer
- Ultrasound and Cavitation Phenomena
- Caveolin-1 and cellular processes
- Heat shock proteins research
- Ferroptosis and cancer prognosis
- Ginger and Zingiberaceae research
- Signaling Pathways in Disease
- Cell Adhesion Molecules Research
- Health Promotion and Cardiovascular Prevention
- Connective tissue disorders research
Xinxiang Medical University
2013-2025
First Affiliated Hospital of Henan University
2024-2025
Yangzhou University
2025
First Affiliated Hospital of Jinan University
2025
Southern Medical University
2016-2024
Dongguan People’s Hospital
2022-2024
Yunnan University
2007-2023
Harbin Medical University
2022-2023
Henan University
2023
Bayi Children's Hospital
2018-2021
Colorectal cancer (CRC) is the third leading cause of cancer‑associated mortality, and a major health problem. Collagen type I α 1 (COL1A1) component collagen I. Recently, it was reported to be overexpressed in variety tumor tissues cells. However, function COL1A1 CRC remains unclear. Herein, present study demonstrated that upregulated paired lymph node tissues. Transwell assays showed promoted cell migration vitro. Moreover, revealed levels were correlated with those WNT/planar polarity...
The Bi2WO6 was prepared by the hydrothermal method and its sonocatalytic activity studied in degradation of methyl orange (MO) solutions. effects catalytic on dye were inspected change absorbance with UV–vis spectrometer. influences operational parameters such as addition amount Bi2WO6, pH, initial concentration dyes, ultrasonic power irradiation time ratio investigated. In addition, obtained results indicated that kinetics sonochemical reactions MO consistent pseudo first-order had...
Breast cancer is the leading cause of cancer-related deaths in females worldwide. Triple-negative breast (TNBC) accounts for 15% all cases and has a poorer prognosis than other subtypes. Moreover, treatment cancer, especially TNBC, remains unsatisfactory. Therefore, novel therapies are urgently needed. Microribonucleic acids (miRNAs) class biomarkers therapeutic targets many types cancers. In present study, expression miR-384 was explored GSE58606 fresh tissues by qPCR. The results showed...
miRNAs are regarded as molecular biomarkers and therapeutic targets for colorectal cancer (CRC), a series of have been proven to involve into CRC carcinogenesis, invasion metastasis. Aberrant miR-422a expression its roles reported in some cancers. However, the function underlying mechanism progression remain largely unknown.
Colorectal cancer (CRC) treatment primarily relies on chemotherapy along with surgery, radiotherapy and, more recently, targeted therapy at the late stages. However, chemotherapeutic drugs have high cytotoxicity, and similarity between effects of these cancerous healthy cells limits their wider use in clinical settings. Targeted monoclonal antibody may compensate for this deficiency. Epidermal growth factor receptor (EGFR)‑targeted a positive effect CRC intact KRAS proto-oncogene GTPase...
// Yong-Xia Wang 1, 2, 3, 4, * , Yan-Ru Chen Shan-Shan Liu Ya-Ping Ye 3 Hong-Li Jiao Shu-Yang Zhi-Yuan Xiao Wen-Ting Wei Jun-Feng Qiu Li Liang Liao Yan-Qing Ding 1 Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 2 School Basic Sciences, Guangdong Province Key Laboratory Molecular Tumor 4 Xinxiang Xinxiang, Henan, These authors have contributed equally to this work Correspondence to: Liao: email: liaowt2002@gmail.com Ding: dyq@fimmu.com...
Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression miR-384 has been reported some cancers. However, role mechanism CRC proliferation remains unknown. was detected their paired normal tissues by real-time PCR. In vivo vitro assays were conducted to confirm CRC. Bioinformatics analysis, luciferase reporter assays, western blot used AKT3 target gene miR-384. Finally, Spearman's correlation analyses...
Fibulin-3 gene has been identified as an antagonist of angiogenesis. We investigated the protein expression and promoter methylation status fibulin-3 in colorectal cancer (CRC) analyzed its correlation with clinicopathological factors. The study population enrolled 85 paired CRC specimens adjacent normal tissues, well 32 cases adenoma. Genomic DNA was extracted from paraffin-embedded samples using manual microdissection. Methylation-specific polymerase chain reaction (MSP) used to determine...
Two rod-shaped, non-motile bacteria were isolated from two separate salt mines in Yunnan, south-western China. These strains, designated YIM D15(T) and J21(T), Gram-negative moderately halophilic. The strains required 6-10 % NaCl (w/v; optimal) for growth. DNA G+C contents of J21(T) 49.0 mol% 48.4 mol%, respectively. predominant isoprenoid quinone was MK-7. polar lipid profiles composed predominantly diphosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine, three unknown lipids...
Objective: To observe the pregnancy outcomes of patients with unexplained recurrent spontaneous abortion (URSA) after interventional treatment or expectant treatment. Methods: This prospective study followed up 398 from March 2017 to September 2022 in seven hospitals. Among them, 267 were diagnosed URSA, including 124 who initially hospital and 143 hospital. All URSA for 33 months. Ongoing rates observed as main outcome indicators. Results: A total 127 became pregnant, 107 them had sustained...
Entrusted by the National Health Commission, national clinical practice guideline on obesity management aims to standardize diagnosis and treatment of prescribe scientific effective plans patients, in order continuously improve homogenization across healthcare organizations, enhance effectiveness long-term health benefits. This is applicable professionals engaging obesity, including physicians, nutritionists, fitness rehabilitation therapists, nurses, case managers, medical administrators,...
A series of novel neutral nickel complexes 4a−e bearing modified β-ketoiminato ligands [(2,6-iPr2C6H3)N═C(R1)CHC(2′-R2C6H4)O]Ni(Ph)(PPh3) (4a, R1 = R2 H; 4b, H, Ph; 4c, Naphth; 4d, CH3, 4e, CF3, Ph) have been synthesized and characterized. Molecular structures 4b 4e were further confirmed by X-ray crystallographic analysis. Activated with B(C6F5)3, all the are active for polymerization ethylene to branched polyethylenes. Ligand structure, i.e., substituents R2, greatly influences not only...
A Gram-staining-negative, catalase-positive, carbaryl-degrading, non-spore-forming, non-motile, rod-shaped bacterium, designated strain X23(T), was isolated from a wastewater treatment system. Phylogenetic analysis based on 16S rRNA gene sequence indicated that the belongs to genus Sphingobium. The highest similarity observed for isolate 96.6 % with type of Sphingobium amiense. Chemotaxonomic data [major ubiquinone: Q-10; major polar lipids: diphosphatidylglycerol, phosphatidylcholine,...
The development and progression of CRC are regarded as a complicated network progressive event including genetic and/or epigenetic alterations. Recent researches revealed that MicroRNAs biomarkers regulators progression. Analyses published microarray datasets miR-450b-5p was highly up-regulated in tissues. In addition, high expression significantly associated with KRAS mutation. However, the role remains unknown. Here, we sought to validate tissues investigate underlying mechanism CRC....
Purpose: To investigate the role and underlying mechanism of scaffold attachment factor B (SAFB) in progression colorectal cancer (CRC).Experimental Design: SAFB expression was analyzed Cancer Outlier Profile Analysis Oncomine 175 paraffin-embedded archived CRC tissues. Gene Ontology analyses were performed to explore progression. Western blot, RT-PCR, luciferase assay, chromatin immunoprecipitation (ChIP) used detect regulation transforming growth factor-β-activated kinase 1 (TAK1) NF-κB...
Iron plays a fundamental role in cell biology and its concentration must be precisely regulated. It is well documented that excess iron burden contributes to the occurrence progression of cancer. Hepcidin secreted by liver an essential orchestrating metabolism. In present study, we aimed investigate ability angelica sinensis polysaccharide (ASP) decrease tumor-bearing mice mechanism ASP regulation hepcidin expression.Western blot, RT-PCR, immunohistochemistry (IHC), enzyme-linked...