A5057792128- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Vasculitis and related conditions
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Cell Adhesion Molecules Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Immunotherapy and Immune Responses
- Venomous Animal Envenomation and Studies
- Health Systems, Economic Evaluations, Quality of Life
- Food Allergy and Anaphylaxis Research
- Anesthesia and Pain Management
- Nerve injury and regeneration
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Drug-Induced Adverse Reactions
- Aortic Disease and Treatment Approaches
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- Eosinophilic Esophagitis
- Neurosurgical Procedures and Complications
- Tracheal and airway disorders
The University of Adelaide
2018-2025
Royal Adelaide Hospital
2013-2025
University of Mobile
2025
Universitat de Barcelona
2006-2024
Framingham State University
2023
Hospital Clínic de Barcelona
2007-2020
Almirall (Spain)
2020
South Australian Health and Medical Research Institute
2019
South Australia Pathology
2009-2015
Hospital de Cruces
2002-2015
Graphical abstractAbstractBackgroundPolyethylene glycol (PEG) is a nonprotein polymer that present in its native (unbound) form as an excipient range of products. It increasingly being utilized clinically the PEGylated liposomal medications and vaccines. PEG cause anaphylaxis small percentage drug reactions; however, diagnosis allergy complicated by variable poor diagnostic performance current skin testing protocols.ObjectiveWe assessed lipid alternative to currently described tests use...
Abstract LL-37 is a cationic antimicrobial peptide derived from neutrophils and keratinocytes. It plays an important role in protection against bacterial infection the skin mucosal surfaces. However, its within blood compartment remains unclear given that serum inhibits bactericidal property. In this study, we show promotes very rapid highly efficient sensing of CpG motifs DNA by human B lymphocytes plasmacytoid dendritic cells (pDCs) serum-containing media whole blood. allowed detection...
Abstract Background Wegener's Granulomatosis and Microscopic Polyangiitis are life-threatening systemic necrotizing vasculitides of unknown aetiology. The appearance circulating antibodies to neutrophil cytoplasmic antigens (ANCA) is strongly associated with the development disease. A link between infection disease has long been suspected, ANCA reported following bacterial viral infections. depletion B cells monoclonal antibody therapy can induce remission, this observation suggests a...
Inappropriate expansion of antibody-secreting cells (ASCs) is typical systemic lupus erythematosus (SLE), but the regulatory signaling pathogenic ASCs unclear. The present study shows that brain-derived neurotrophic factor precursor (proBDNF) and its high-affinity pan-75 neurotrophin receptor (p75NTR) are highly expressed in CD19+CD27hiCD38hi patients with SLE CD19+CD44hiCD138+ lupus-like mice. increased proBDNF+ were positively correlated clinical symptoms higher titers autoantibodies SLE....
INTRODUCTION: Eosinophilic esophagitis (EoE) is associated with atopy; however, recent studies have identified an association food-specific immunoglobulin G 4 (FS-IgG ) rather than E antibodies. This study aimed to evaluate the role of serum FS-IgG in guiding elimination diet and its outcomes. METHODS: Patients without EoE were enrolled a prospective, controlled, single tertiary center trial. Serum titers, esophageal eosinophil counts, dysphagia symptom questionnaire scores assessed,...
This study evaluated the safety and efficacy of influenza vaccination in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.Thirty-one who were remission randomized to receive either a trivalent vaccine or no vaccine. Vaccine was assessed at 28 days. Patients followed for 6 months signs reactivation disease. In addition, 67 healthy individuals assess its potential triggering formation autoantibodies.Compared did not vaccine, vaccinated achieved effective responses all...
Rationale: Brain-derived neurotrophic factor precursor (proBDNF) is expressed in the central nervous system (CNS) and immune system.However, role of proBDNF pathogenesis multiple sclerosis (MS) unknown.Methods: Peripheral blood post-mortem brain spinal cord specimens were obtained from patients to analyze expression peripheral lymphocytes infiltrating cells lesion site.The profile was also examined experimental autoimmune encephalomyelitis (EAE) mouse model, polyclonal monoclonal...
Background: Failure to develop protective immunity in response vaccination is common among kidney transplant recipients, rendering them susceptible severe infection. Novel strategies are required. Here, we investigated the potential of mechanistic-target-of-rapamycin (mTOR) inhibitors improve vaccine responses. Methods: Humoral and cellular responses primary COVID-19 (ChAdOx1 or BNT162b2) were assessed for recipients receiving mTOR inhibitor-based (mTOR inhibitor, mycophenolate,...
Brain-derived neurotrophic factor precursor (proBDNF) has been reported to strengthen the dysfunction of monocytes/macrophages in animal studies. However, it is still unknown roles proBDNF monocytes inflammatory diseases humans. In present study, we showed that and pan receptor p75 were significantly upregulated from healthy donors (HD) after lipopolysaccharide treatment. Exogenous treatment CD40 proinflammatory cytokines expression including interleukin (IL)-1β, IL-6, tumor necrosis...
Introduction/Rationale: In chronic obstructive pulmonary disease (COPD), defective macrophage phagocytic clearance of cells undergoing apoptosis by efferocytosis may lead to secondary necrosis the uncleared and contribute airway inflammation. The precise mechanisms for this phenomenon remain unknown. LC3-associated phagocytosis (LAP) is indispensable effective efferocytosis. We hypothesized that cigarette smoke inhibits regulators LAP pathway, potentially contributing airways inflammation...
Abstract Recognizing the limitations of current therapies for Addison's disease, novel treatments that replicate dynamic physiologic corticosteroid secretion, under control ACTH, are required. The aim these experiments was to evaluate feasibility adrenocortical cell transplantation (ACT) in a large animal model, adapting methods successfully used intracutaneous pancreatic islet transplantation, using fully biodegradable temporizing matrix. Autologous porcine ACT undertaken by bilateral...
Elucidation of the biological functions extracellular vesicles (EVs) and their potential roles in physiological pathological processes is an expanding field research. In this study, we characterized USC-derived EVs studied capacity to modulate human immune response vitro. We found that are a heterogeneous population, ranging size from micro-vesicles (150 nm-1 μm) down exosomes (60-150 nm). Regarding immunomodulatory functions, upon isolation, nm) induced B cell proliferation IgM antibody...
Pentosan polysulphate sodium (PPS) is a promising therapeutic agent for blocking knee pain in individuals with osteoarthritis (KOA). The mode of action PPS this context unknown. We hypothesised that the osteocyte, being principal cell type sub-chondral bone, was capable expressing mediator Nerve Growth Factor (NGF), and may be altered presence PPS. tested expression NGF response to or absence proinflammatory cytokine tumour necrosis factor-alpha (TNFα), human osteocytes. For we...
Kidney transplant recipients (KTRs) are highly vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and disease 2019 (COVID-19). The 28-day case mortality for KTRs is 24%, mounting evidence suggests poor immunogenicity clinical effectiveness of vaccines in this group.1Phanish M. Ster I.C. Ghazanfar A. et al.Systematic review meta-analysis COVID-19 kidney recipients, the South West London Transplant Network experience.Kidney Int Rep. 2021; 6: 574-585Google...
Snakebite is predominantly an occupational disease affecting poor rural farmers in tropical regions and was recently added to the World Health Organisation list of Neglected Tropical Diseases (NTD). We document overview methodologies developed deployed Myanmar Project, a foreign aid project largely funded by Australian Government, with core aim "improve outcomes for snakebite patients". A multidisciplinary team experts assembled that worked collaborative manner colleagues Myanmar, first...
Abstract Inadequate immune response to vaccination is a long-standing problem faced by immunosuppressed kidney transplant recipients (KTRs), requiring novel strategies improve vaccine efficacy. In this study, the potential of mechanistic target rapamycin inhibitors (mTORi) T cell responses COVID-19 was investigated. Following primary with adenoviral (ChAdOx1) or mRNA (BNT162b2) vaccines, KTRs receiving demonstrated greater than those healthy individuals, characterized increased frequencies...
Abstract The interplay between mesenchymal stem cells (MSCs) and immune has been studied for MSCs isolated from different tissues. However, the immunomodulatory capacity of urine (USCs) not adequately researched. present study reports on effect USCs peripheral blood lymphocytes. were characterized before coculture with resting anti-CD3/CD28 bead stimulated Similarly to bone marrow (BM-MSCs), inhibited proliferation activated T lymphocytes induced their apoptosis. they also strong activation,...