A5061208097- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neural Engineering
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Advanced Proteomics Techniques and Applications
- Click Chemistry and Applications
- Biotin and Related Studies
- Luminescence Properties of Advanced Materials
- Nanoplatforms for cancer theranostics
- Protein Degradation and Inhibitors
- Chemistry and Chemical Engineering
- Advanced Nanomaterials in Catalysis
- Muscle metabolism and nutrition
- Electrochemical Analysis and Applications
- Machine Learning in Materials Science
- Chemical Reaction Mechanisms
- Synthesis and Biological Evaluation
- Nanocluster Synthesis and Applications
- Photoreceptor and optogenetics research
- Chemical Synthesis and Analysis
- Metabolomics and Mass Spectrometry Studies
- Nuclear materials and radiation effects
- Photoacoustic and Ultrasonic Imaging
Stanford University
2022-2024
Agency for Science, Technology and Research
2018-2024
Institute of Materials Research and Engineering
2018-2024
University of Illinois Urbana-Champaign
2017-2019
Urbana University
2017
Intrinsically stretchable bioelectronic devices based on soft and conducting organic materials have been regarded as the ideal interface for seamless biocompatible integration with human body. A remaining challenge is to combine high mechanical robustness good electrical conduction, especially when patterned at small feature sizes. We develop a molecular engineering strategy topological supramolecular network, which allows decoupling of competing effects from multiple building blocks meet...
Spatial and temporal distributions of metal ions in vitro vivo are crucial our understanding the roles biological systems, yet there is a very limited number methods to probe with high space time resolution, especially vivo. To overcome this limitation, we report Zn2+-specific near-infrared (NIR) DNAzyme nanoprobe for real-time ion tracking spatiotemporal control early embryos larvae zebrafish. By conjugating photocaged DNAzymes onto lanthanide-doped upconversion nanoparticles (UCNPs), have...
Multicellular biological systems, particularly living neural networks, exhibit highly complex organization properties that pose difficulties for building cell-specific biocompatible interfaces. We previously developed an approach to genetically program cells assemble structures modify electrical of neurons in situ, opening up the possibility minimally invasive and However, efficiency biocompatibility this were challenged by limited membrane targeting constructed materials. Here, we design a...
Monodispersed PAA-Au/Fe<sub>3</sub>O<sub>4</sub> NPs were engineered for highly sensitive CRP assay with zwitterionic glycerophosphoryl choline as the co-blocking agent.
Cell surface proteins contribute to cellular identity and mediate a myriad of pathological normal physiological processes. Multiple induced proximity strategies have emerged manipulate the cell proteome, wherein protein interest can be depleted in targeted manner. These applied diseases marked by presence pathogenic protein. However, many pathologies result from absence critical proteins. Restoring deficient cell-surface without genetic intervention remains formidable challenge. We sought...
Cell surface proteins contribute to cellular identity and mediate a myriad of pathological normal physiological processes. Multiple induced proximity strategies have emerged manipulate the cell proteome, wherein protein interest can be depleted in targeted manner. These applied diseases marked by presence pathogenic protein. However, many pathologies result from absence critical proteins.1–4 Restoring deficient cell-surface without genetic intervention remains formidable challenge. We sought...
DNA-modified particles are used extensively for applications in sensing, material science, and molecular biology. The performance of such is greatly dependent on the degree surface coverage, but existing methods quantitation can only be employed certain particle compositions and/or conjugation chemistries. We have developed a simple broadly applicable exonuclease III (Exo III) digestion assay based cleavage phosphodiester bonds—a universal feature particles—to accurately quantify DNA probe...
Abstract Intrinsically stretchable bioelectronic devices based on soft and conducting organic materials have been regarded as the ideal interface for seamless biocompatible integration with human body. However, grand challenge remains polymer to possess both high mechanical ductility good electrical conduction at cellular level feature sizes. This longstanding material limitation in bioelectronics has impeded full exploitation of its unique benefits. Here, we introduce a new molecular...
ADVERTISEMENT RETURN TO ISSUEPREVFirst ReactionsNEXTGapping into Ultrahigh Surface-Enhanced Raman Scattering AmplificationNext-generation SERS-active dealloyed particles with intra-nanogaps might empower and drive the translation of SERS techniques clinics.Kang Yong Loh† Xiaogang Liu†‡View Author Information† Institute Materials Research Engineering, Agency for Science, Technology (A*STAR), Innovis, 138634, Singapore‡ Department Chemistry, National University Singapore, Singapore 117543,...
Photoacoustic tomography offers a powerful tool to visualize biological relevant molecules and understand processes within living systems at high resolution in deep tissue, facilitated by the conversion of incident photons into low-scattering acoustic waves through non-radiative relaxation. Although current endogenous exogenous photoacoustic contrast agents effectively enable molecular imaging tissues, their broad absorption spectra visible near-infrared (NIR) range limit multiplexed...
Catalytic reactions of a broad range abiotic molecules and macromolecules are beyond the native capabilities mammals. Natural enzymes from prokaryotes or plant-based eukaryotes have limited substrate scopes. Therefore, broadening catalytic bond-forming that function in physiological conditions would enable syntheses vast array directly within biological systems. This approach may provide an alternative way to modulate cellular behaviors if such can be synthesized with spatiotemporal control...
Abstract Multicellular biological systems, most notably living neural networks, exhibit highly complex physical organization properties that pose challenges for building cell-specific and biocompatible interfaces. We developed a novel approach to genetically program cells chemically assemble artificial structures modify the electrical of neurons in situ , opening up possibility minimally-invasive interfaces with circuits animals. However, efficiency biocompatibility this were challenged by...