A5100628606- Microbial Natural Products and Biosynthesis
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- Genomics and Phylogenetic Studies
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Microbial Metabolism and Applications
- Bacterial biofilms and quorum sensing
- Subcritical and Supercritical Water Processes
- Glycosylation and Glycoproteins Research
- Coal and Its By-products
- Face Recognition and Perception
- Nuclear Structure and Function
- Nicotinic Acetylcholine Receptors Study
- Chemical synthesis and alkaloids
- Cholesterol and Lipid Metabolism
- RNA and protein synthesis mechanisms
- Cancer therapeutics and mechanisms
- Advanced Synthetic Organic Chemistry
- Gallbladder and Bile Duct Disorders
- Osteoarthritis Treatment and Mechanisms
- Diagnosis and Treatment of Venous Diseases
- Monoclonal and Polyclonal Antibodies Research
- Tuberculosis Research and Epidemiology
- Pediatric health and respiratory diseases
Shenzhen Bay Laboratory
2023-2024
Chinese Medical Association
2023
Guangdong Academy of Medical Sciences
2023
Southern Medical University
2023
Guangdong Provincial People's Hospital
2023
Shandong First Medical University
2022
Jinan University
2020-2022
Southern University of Science and Technology
2020-2022
Shandong Provincial Hospital
2022
Anhui University
2019
To investigate the role of glycine betaine in photosynthesis under stress, a transgenic wheat (Triticum aestivum L.) line T6 overaccumulating and its wild type Shi4185 were used. Seedlings exposed to conditions drought (30%, PEG-6000), heat (40°C) their combination. The results revealed ultrastructural damage chloroplast thylakoid lamellae with withered phenotype by both was exacerbated combination heat. appearance K step typical O-J-I-P curve decrease Hill activity indicated reduction...
To date, a great number of studies have demonstrated that altered expression kinesins is associated with development and progression various human cancers. Kinesin family member 26B (KIF26B), the kinesin superfamily proteins (KIFs), essential for kidney development. However, role KIF26B during tumorigenesis limited. Here, we demonstrate both mRNA protein are overexpression in breast cancer tissues by RT-qPCR western blot. Immunohistochemistry revealed significantly correlated...
Plitidepsin (or dehydrodidemnin B), an approved anticancer drug, belongs to the didemnin family of cyclic depsipeptides, which are found in limited quantities marine tunicate extracts. Herein, we introduce a new approach that integrates microbial and chemical synthesis generate plitidepsin its analogues. We screened Tistrella strain library identify potent B producer, then introduced second copy biosynthetic gene cluster into genome, resulting titer approximately 75 mg/L. Next, developed two...
Abstract Plitidepsin (or dehydrodidemnin B), an approved anticancer drug, belongs to the didemnin family of cyclic depsipeptides, which are found in limited quantities marine tunicate extracts. Herein, we introduce a new approach that integrates microbial and chemical synthesis generate plitidepsin its analogues. We screened Tistrella strain library identify potent B producer, then introduced second copy biosynthetic gene cluster into genome, resulting titer approximately 75 mg/L. Next,...
The co-thermal dissolution (CTD) behavior of Shenmu–Fugu subbituminous coal (SFSBC) and sawdust was investigated in this study. synergic effect between SFSBC CTD probed. individual thermal (TD) showed that gave much higher yield (TDY) lower soluble (TSY) than SFSBC. This resulted difference (TDY–TSY) for compared to at the same condition. CTDs 1-methylnaphthalene (1-MN) different temperatures were carried out. results suggested there existed a negative TDY whole range studied, but positive...
Tuberculosis remains an important cause of morbidity and mortality throughout the world. Notably, number multi drug resistant cases is increasing concern. This problem points to urgent need for novel compounds with antimycobacterial properties improve existing therapies. Whole-cell-based screening activity against Mycobacterium tuberculosis complex strains in presence linezolid was performed this study. A set 15 bioactive vitro were identified a minimal inhibitory concentration less than 2...
Glycine betaine (GB) is an effective compatible solute that improves the tolerance in plants to various stresses. We investigated effects of 2 mM GB applied roots a tobacco (Nicotiana tabacum L.) cultivar on enhancing photosynthesis under low-temperature (LT) stress (5/5 °C, 12/12 h, 300 µmol m-2 s-1) and subsequent recovery (25/18 °C) from stress. The net photosynthetic rate, intrinsic efficiency measured as ratio variable maximum fluorescence, actual photochemistry photosystem well ATPase...
Abstract The assembly line biosynthesis of the powerful anticancer‐antiviral didemnin cyclic peptides is proposed to follow a prodrug release mechanism in Tristella bacteria. This strategy commences with formation N‐terminal scaffolds and culminates their cleavage during cellular export mature products. In this study, comprehensive exploration genetic biochemical aspects enzymes responsible for both acylated peptide provided. process involves N‐acyl‐polyglutamine moieties orchestrated by...
Abstract Plitidepsin, a marine-derived anticancer medicine, is being tested in phase III clinical trials for treating COVID-19. However, the current supply of plitidepsin relies on laborious chemical synthesis processes. Here, we present new approach that combines microbial and to produce plitidepsin. We screened Tistrella strain library identify high-yield didemnin B producer, then introduced second copy biosynthetic gene cluster into its genome, resulting highest yield reported literature....
Previous brain decoding studies using functional magnetic resonance imaging (fMRI) have greatly advanced our understanding of human visual coding and non-invasive brain-machine interfaces. However, most these focus on classifying a limited number image categories or reconstructing images with additional information, e.g., semantic textual cues. Constraint-free reconstruction remains scarce. Here, we propose generative network based the diversity cortex (FDGen) that takes multivariate...
BackgroundThe establishment of the anterior-posterior (A-P) axis is a crucial step during tissue repair and regeneration. Despite association reported recently N6-methyladenosine (m6A) with regeneration, mechanism underlying regulation m6A in A-P specification regeneration remains unknown. Herein, we deciphered landscape at single-base resolution multiple time points constructed de novo transcriptome assembly Dugesia japonica planarian.ResultsImmunofluorescence staining comparative analysis...
This study investigated the current status of patients' knowledge and clinical compliance with ankle pump exercises in order to better enhance patient education improve exercises.A cross-sectional survey exercise awareness was conducted using a self-designed questionnaire. The questionnaire consisted general demographic information questionnaire, on perceptions questionnaire.A total 2,203 patients from 53 departments participated this survey. 87.8% considered important, 92.1% could grasp...
Background Hypervirulent Klebsiella pneumoniae lacking classical virulence factors is uncommon, and the mechanisms of this organism are not understood. Methods Following a retrospective study carbapenem-resistant K. based on core genome multilocus sequence typing (cgMLST), isolates that caused high mortality were investigated with genome-wide association (GWAS), proteome analysis an animal model. Results The sublineage type 11 (ST11) , which belongs to complex 3176 (CT3176) K-locus 47...
To date, a great number of studies have demonstrated that altered expression kinesins is associated with development and progression various human cancers.Kinesin family member 26B (KIF26B), the kinesin superfamily proteins (KIFs), essential for kidney development.However, role KIF26B during tumorigenesis limited.Here, we demonstrate both mRNA protein are overexpression in breast cancer tissues by RT-qPCR western blot.Immunohistochemistry revealed significantly correlated clinicopathological...
Abstract The Tistrella genus can produce the cyclic depsipeptide didemnin B, but biosynthetic origin of its analogue, plitidepsin, remains unknown. Plitidepsin is an approved anticancer drug and anti-COVID-19 agent in phase III clinical trials. Here, we employed a novel approach that combined microbial chemical synthesis to plitidepsin. We first investigated global distribution , which inspired us retrieve screen library . Using genetic heterologous expression, we, for time, experimentally...