A5100368940- Phytochemical Studies and Bioactivities
- Natural product bioactivities and synthesis
- Forensic and Genetic Research
- Genetic diversity and population structure
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Antioxidant Activity and Oxidative Stress
- Extracellular vesicles in disease
- Genomics and Phylogenetic Studies
- Phytochemistry and Bioactive Compounds
- Cancer-related Molecular Pathways
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Identification and Quantification in Food
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cholesterol and Lipid Metabolism
- Circular RNAs in diseases
Gannan Medical University
2014-2024
Shanghai Jiao Tong University
2024
Shanxi University
2023-2024
Wannan Medical College
2024
Central South University
2022
Kunming Medical University
2022
First Affiliated Hospital of Zhengzhou University
2021
Institute of Forensic Science
2017-2021
Zhejiang University
2011-2020
Shanghai Public Security Bureau
2020
// YaXing Gui 1 , Hai Liu LiShan Zhang Wen Lv and XingYue Hu Department of Neurology, Sir Run Shaw Hospital, Affiliated with School Medicine, Zhejiang University, Hangzhou, Zhejiang, China Correspondence to: Gui, email: Keywords : Parkinson’s diseases (PD), Alzheimer’s (AD), cerebrospinal fluid (CSF), exosome, microRNA, Pathology Section Received May 24, 2015 Accepted September 30, Published October 19, Abstract The differential diagnosis (PD) is challenging, especially in the...
Abstract Background The expression of CYP4Z1 and the pseudogene CYP4Z2P has been shown to be specifically increased in breast cancer by our group others. Additionally, we previously revealed roles competitive endogenous RNA (ceRNA) network mediated these genes (ceRNET_CC) angiogenesis, apoptosis, tamoxifen resistance. However, ceRNET_CC regulating stemness cells mechanisms through which is regulated remain unclear. Methods Transcriptional factor six2, CYP4Z1-3′UTR, CYP4Z2P-3′UTR were stably...
Exosomes carry large cargo of proteins, lipids, and nucleic acids, serving as versatile biomarkers for disease diagnosis vehicles drug delivery. However, up to date, no well recognized standard procedures exosome storage were available clinical application. This study aimed determine the optimal conditions anticoagulants plasma-derived isolation. Fresh whole blood samples collected from healthy participants preserved in four different including sodium citrate (SC1/4), (SC1/9), lithium...
The present study was undertaken to investigate the gender-related liver injury induced by Dioscorea bulbifera L. (DB), a traditional medicinal plant, in mice, and further explored its hepatotoxic chemical compound. Serum tissue samples were collected at 0, 4, 8, 12 h, after mice administrated orally with 640 mg/kg ethyl acetate extracts (EF) isolated from DB. After treatments, serum alanine transaminase (ALT) aspartate (AST) activities both significantly elevated. Liver lipid peroxidation...
Beijing Black pig is an excellent cultivated black breed in China, with desirable body shape, tender meat quality and robust disease resistance. To explore the level of admixture selection signatures pigs, a total number 90 individuals covering nine breeds were used our study, including pig, Large White, Landrace, Duroc, Lantang Luchuan Mashen Huainan Min pig. These animals resequenced 18.19 folds mapped read depth on average. Generally, we found that was genetically closer to commercial by...
Background: Reineckia carnea is commonly used to treat cough, pneumonia and other diseases in China. In our previous study, it was found that the ethanol extracts of have a strong inhibitory effect on proliferation human lung cancer A549 cells. Here, we isolated gracillin from for first time. Purpose: Clarify antiproliferation cells further explore its mechanisms via mitochondrial pathway. Methods: Gracillin purified by silica gel, D-101 macroporous resin preparative RP-HPLC, then identified...
Overexposure to glucocorticoid (GC) produces various clinical complications, including osteoporosis (OP), dyslipidemia, and hypercholesterolemia. Geniposide (GEN) is a natural iridoid compound isolated from Eucommia ulmoides. Our previous study found that GEN could alleviate dexamethasone (DEX)-induced differentiation inhibition of MC3T3-E1 cells. However, whether protected against Dex-induced cholesterol accumulation in osteoblasts was still unclear.DEX used induce rat OP. Micro-CT data...
The leading cause of cancer deaths is lung cancer, non-small cell (NSCLC), the most common type cancers, remains a difficult to treat and cure. It urgent develop new products NSCLS. Gracillin, extracted from Reineckia carnea, Dioscorea villosa, other medicinal plants, has anti-tumor potential with toxic effect on variety tumor cells such as NSCLC. However, anti-NSCLC mechanism gracillin not completely clear. In this study, A549 athymic nude mice were used models evaluate effects gracillin....
The purpose of this study was to evaluate the value vascular endothelial growth factor-A (VEGF-A) expression and other confirmed prognostic factors in predicting clinical outcomes after resection gallbladder carcinoma (GBC). Between January 1999 2006, a total 84 consecutive non-selected patients who underwent for GBC were retrospectively reviewed. Of studied, 45 cases (53.6%) exhibited high VEGF-A placed into group. 14 (16.7%) that showed no VEGF 25 (29.7%) had lower levels pooled low group...