A5100688814- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid Membrane Structure and Behavior
- Nerve injury and regeneration
- Autophagy in Disease and Therapy
- Protease and Inhibitor Mechanisms
- Histone Deacetylase Inhibitors Research
- Tryptophan and brain disorders
- Calpain Protease Function and Regulation
- Selenium in Biological Systems
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Force Microscopy Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- S100 Proteins and Annexins
- Ion channel regulation and function
- Alzheimer's disease research and treatments
- Anesthesia and Neurotoxicity Research
- Pharmacogenetics and Drug Metabolism
- Autism Spectrum Disorder Research
- Plant nutrient uptake and metabolism
- Genomics, phytochemicals, and oxidative stress
- Cell death mechanisms and regulation
Chung-Ang University
2017-2024
National Institute of Neurological Disorders and Stroke
2016-2024
Seoul National University
2009-2024
Konkuk University
2010-2022
Cheongju University
2015-2021
Kunsan National University
2021
Government of the Republic of Korea
2018
Atatürk University
2018
Kangwon National University
2018
Cairo University
2018
Nanoplastics, arising from the fragmentation of plastics into environmental pollutants and specialized commercial applications, such as cosmetics, have elicited concerns due to their potential toxicity. Evidence suggests that oral ingestion nanoplastics smaller than 100 nm may penetrate brain induce neurotoxicity. However, comprehensive research in this area has been hampered by technical challenges associated with detection synthesis nanoplastics. This study aimed bridge gap successfully...
Abstract Physical activity has many beneficial effects on metabolic disorders, such as obesity, insulin resistance, and diabetes. Meteorin-like protein (METRNL), a novel secreted homologous to the neurotrophin Metrn, is induced after exercise in skeletal muscle. Herein, we investigated of METRNL lipid-mediated inflammation resistance muscle via AMP-activated kinase (AMPK) or peroxisome proliferator-activated receptor δ (PPARδ). Treatment with suppressed inflammatory markers, nuclear factor...
The aim of this study was to investigate the potential anti-cancer effects probiotic cell-free supernatant (CFS) treatment using Lactobacillusfermentum for colorectal cancer (CRC) in 3D culture systems. Cell viability assessed MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt) assays, whereas apoptosis monitored through RT-qPCR analysis Bax, Bak, Noxa, and Bid mRNA expressions addition flow cytometry Lactobacillus (LCFS) treatment. Our...
Recent studies found that short-chain fatty acids (SCFAs), which are produced through bacterial fermentation in the gastrointestinal tract, have oncoprotective effects against cervical cancer. The most common SCFAs well known include acetic acid, butyric and propionic among acid (PA) has been reported to induce apoptosis HeLa cells. However, mechanism suppress cell viability remain poorly understood. Our study aims provide a more detailed look into of PA Flow cytometry analysis revealed...
Docosahexaenoic acid (DHA) and its bioactive compounds may have suppressive effects on inflammation, endoplasmic reticulum (ER) stress, insulin resistance. Protectin DX (PDX), a double lipoxygenase product from DHA has shown effect inflammation However, the of PDX ER stress hepatic steatosis not been elucidated yet. Herein we report that could stimulate AMP-activated protein kinase (AMPK) phosphorylation, thereby upregulating oxygen-regulated 150 (ORP150) expression in dose-dependent manner....
Compared to other organs, the brain has limited antioxidant defenses. In particular, hippocampus is central region for learning and memory highly susceptible oxidative stress. Glial cells are most abundant in brain, sustained glial cell activation critical neuroinflammation that aggravates neuropathology neurotoxicity. Therefore, regulating a promising neurotherapeutic treatment. Quinic acid its derivatives possess anti-oxidant anti-inflammatory properties. Although previous studies have...
Abstract Membrane budding entails forces to transform flat membrane into vesicles essential for cell survival. Accumulated studies have identified coat-proteins (e.g., clathrin) as potential factors. However, mediating many non-coated buddings remain unclear. By visualizing proteins in endocytic live neuroendocrine cells, performing vitro protein reconstitution and physical modeling, we discovered how non-coated-membrane is mediated: actin filaments dynamin generate a pulling force...
Tissue plasminogen activator (tPA) is expressed in several regions of brain and plays regulatory roles such as neurite outgrowth, synaptic plasticity long term potentiation. The activity tPA regulated by an endogenous inhibitor inhibitor‐1 (PAI‐1), which mainly astrocytes. Valproic acid (VPA), a histone deacetylase that used for the treatment epilepsy bipolar disorders, promotes extension, neuronal growth has neuroprotective effect neurodegenerative diseases. In this study, we examined...
Neural stem cells (NSCs) are primary progenitor in the early developmental stage brain that initiate a diverse lineage of differentiated neurons and glia. Radial glial (RGCs), type neural cell ventricular zone, essential for nurturing delivering new immature to appropriate cortical target layers. Here we report Anoctamin 1 (ANO1)/TMEM16A, Ca2+-activated chloride channel, mediates Ca2+-dependent process extension RGCs. ANO1 is highly expressed functionally active RGCs mouse embryonic zone....
Neural progenitor cells (NPC) are self-renewing multipotent that generate neurons and glial in the brain. NPCs glia not only during development but also after neural injury. Recent studies have shown endogenous activated brain injury migrate toward damaged areas where astrocyte activation occurs. Considering massive proliferation of astrocytes as well production several kinds cytoactive molecules injury, such NO, growth factors cytokines, it is tempting to think released by regulate...
Calcium-activated chloride channels (CaCCs) mediate numerous physiological functions and are best known for the transport of electrolytes water in epithelia. In intestine, CaCC currents considered necessary secretion fluid to protect intestinal epithelium. Although genetic ablation ANO1/TMEM16A, a gene encoding CaCC, reduces carbachol-induced fluid, its mechanism action is still unknown. Here, we confirm that ANO1 essential fluid. Carbachol-induced transepithelial were reduced proximal colon...
T-type calcium channels are low voltage-activated that evoke small and transient currents.Recently, have been implicated in neurodevelopmental disorders such as autism spectrum disorder neural tube defects.However, their function during embryonic development is largely unknown.Here, we investigated the expression of progenitor cells (NPCs).First, compared channel subtypes (CaV3.1,3.2, 3.3) NPCs differentiated (neurons astrocytes).We detected all neurons but not astrocytes.In NPCs, CaV3.1 was...
Abstract Membrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve membrane coat-forming proteins, including the most observed clathrin, form Ω-shape profiles helix-forming proteins dynamin constrict Ω-profiles’ pores thus mediate fission. Challenging this concept, we report that polymerized clathrin required for pore closure around base/pore region mediates constriction/closure in neuroendocrine chromaffin...