A5100334593- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Polyamine Metabolism and Applications
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Endoplasmic Reticulum Stress and Disease
- Nuclear Receptors and Signaling
- Wnt/β-catenin signaling in development and cancer
- Prostate Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- interferon and immune responses
- Ocular Oncology and Treatments
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Galectins and Cancer Biology
- Immune cells in cancer
Harbin Medical University
2016-2025
Huazhong University of Science and Technology
2018-2024
Union Hospital
2024
Kunming Medical University
2023
Union Hospital
2018-2023
First Affiliated Hospital of Kunming Medical University
2023
81th Hospital of PLA
2021
Wuhan Union Hospital
2020
Changhai Hospital
2019
Second Military Medical University
2019
Circular RNAs (circRNAs) are essential participants in the development and progression of various malignant tumors. Previous studies have shown that cell migration-inducing protein (CEMIP) accelerates prostate cancer (PCa) anoikis resistance (AR) by activating autophagy. This study focused on effect circCEMIP PCa metastasis. gradually revealed role circ_0004585 via quantitative real-time PCR (qRT-PCR) analysis, western blotting, pull-down assays, dual fluorescence reporter assays....
Circular RNAs (circRNAs) are now recognized as large species of transcripts in eukaryotic cells. From model organisms such C. elegans, Drosophila, mice to human beings, thousands circRNAs formed from back-splicing exons have been identified. The known complexity transcriptome has greatly expanded upon the discovery these RNAs. Studies about biogenesis and physiological functions yielded substantial knowledge for circRNAs, they more likely be viewed regulatory elements coded by genome rather...
Abstract Both circular RNAs (circRNAs) and cancer stem cells (CSCs) are separately known to be involved in cancer, but their interaction remains unclear. Here, the regulation of hepatocellular CSC self‐renewal is discovered by a circRNA, circ‐MALAT1, which produced back‐splicing long noncoding RNA, MALAT1. Circ‐MALAT1 highly expressed CSCs from clinical carcinoma samples under mediation an RNA‐binding protein, AUF1. Surprisingly, circMALAT1 functions as brake ribosomes retard PAX5 mRNA...
Abstract The survival of cancer cells after detaching from the extracellular matrix (ECM) is essential for metastatic cascade. programmed cell death detachment known as anoikis, acting a metastasis barrier. However, most aggressive escape anoikis and other patterns to initiate This study revealed role migration-inducing protein (CEMIP) in autophagy modulation resistance during ECM detachment. CEMIP amplification resulted protective induction via mechanism dependent on dissociation B-cell...
Abstract Recent research has shown that ferroptosis, the iron-dependent accumulation of lipid peroxides leads to cell death, suppresses cancer metastasis. However, role ferroptosis in prostate metastasis not been completely elucidated. In current study, we identified essential serum/glucocorticoid regulated kinase 2 (SGK2) promoting by inhibiting ferroptosis. We found expression SGK2 was higher metastatic and predicted poor clinical outcomes. knockdown inhibited capacity cells vivo vitro,...
Cells detached from the extracellular matrix (ECM) can trigger different modes of cell death, and survival ECM-detached cells is one prerequisites for metastatic cascade. Ferroptosis, a form iron-dependent programmed has recently been found to be involved in matrix-detached cancer cells. However, molecular mechanisms by which escape ferroptosis are not fully understood. Here, we observed that migration-inducing protein (CEMIP) upregulation facilitates resistance during ECM detachment...
Acquisition of the chemoresistance to docetaxel (DTX), a microtubule-targeting agent, has been huge obstacle in treatment for metastatic castration-resistant prostate cancer (mCRPC). Recently, strategies targeting mitosis error correction mechanism including chromosomal passenger complex (CPC) were reported reverse resistance anticancer agents. Meanwhile, accumulating evidence indicated important roles circRNAs DTX (PCa). However, whether could regulate chemosensitivity by affecting remains...
Purpose: Nudix Hydrolase 21 (NUDT21) is a crucial mediator involved in alternative polyadenylation (APA), and this molecule has been reported to be tumor suppressor human cancers.However, neither the role NUDT21 plays bladder cancer (BC) nor mechanisms which are have investigated.Methods: Expression levels of BC were evaluated with real-time PCR, western blotting, immunohistochemistry (IHC).In vitro vivo assays performed investigate function tumorigenesis cells.The TOP/FOP flash reporter...
Abstract Erdafitinib is a novel fibroblast growth factor receptor (FGFR) inhibitor that has shown great therapeutic promise for solid tumor patients with FGFR3 alterations, especially in urothelial carcinoma. However, the mechanisms of resistance to FGFR inhibitors remain poorly understood. In this study, we found could kill cells by inducing incomplete autophagy and increasing intracellular reactive oxygen species levels. We have established an Erdafitinib‐resistant cell line, RT‐112‐RS....
Abstract Background The abnormal expression of circular RNAs (circRNAs) in uveal melanoma (UM) has been revealed, but the specific underlying molecular mechanism their association with UM development not fully explored. Methods levels circ_0119872, G3BP1 and miR-622 cell lines tissues were determined by quantitative real-time PCR (qRT-PCR) western blotting assays. In vitro vivo assays performed to investigate function circ_0119872 tumorigenesis cells. relationships among predicted using...
Abstract Abiraterone, a novel androgen synthesis inhibitor, has been approved for castration-resistant prostate cancer (CRPC) treatment. However, most patients eventually acquire resistance to this agent, and the underlying mechanisms related remain largely unelucidated. Lysine acetyltransferase 2 A (KAT2A) reported enhance transcriptional activity certain histone or non-histone proteins through acetylation post-translational modification of receptor (AR). Therefore, we hypothesised that...
// Fucheng Zhou 1, * , Yang Li Zhen Hao 1 Xuanxi Liu Liang Chen Yu Cao Zuobin Fei Yuan Jie Jianjiao Wang Yongri Zheng Deli Dong 2 Shan Bian 3 Baofeng Chuanlu Jiang Qingsong Department of Neurosurgery, The 2nd Affiliated Hospital, Harbin Medical University, 150086, China Institute Molecular Biology, Austrian Academy Sciences, Vienna, Austria These authors have contributed equally to this work Correspondence to: Li, email: qing1songli@sina.com Jiang, jiangchuanlu123@sina.com Yang,...
R-spondin 3 (RSPO3) is a secreted protein that associates directly with Wnt/β-catenin signaling. However, its functional contribution and prognostic value in human bladder cancer remain unclear. Here, we showed RSPO3 upregulated tissues cells, high expression of correlates advanced clinicopathological features, poor prognosis disease progression patients. Furthermore, observed ectopic or knockdown profoundly promoted inhibited, respectively, the invasive ability cells. Mechanistically, via...
Muscle-invasive and metastatic bladder cancer indicates extra worse prognosis. Accumulating evidence roots for the prominent role of circular RNAs(circRNAs) in cancer, while mechanisms linking circRNAs metastasis remain limitedly investigated. Here, we identified a significantly upregulated circRNA candidate, hsa_circ_0001583, from online datasets. Validated by qRT-PCR, PCR, sanger sequencing, actinomycin D RNase R digestion experiments, hsa_circ_0001583 was proved to be genuine RNA with...
Bladder cancer is one of the most common urogenital malignancies. However, its pathogenesis, especially molecular mechanisms remain elusive. Thus, understanding underlying bladder important for discovery novel therapeutic paradigms these diseases. In current study, we found that micro-RNA (miR)-190b highly expressed in tissues and cells. Overexpression miR-190b enhanced proliferation, growth, migration invasion capabilities, angiogenesis cells, whereas downregulation reversed effects. Target...
Bladder cancer (BC) is a common genitourinary malignancy. This study investigated the regulatory effects of an exonic circRNA, circNUDT21, in progression BC. The circNUDT21 level was overexpressed BC tissues and cell lines as compared to normal controls. Overexpression silencing promoted inhibited, respectively, proliferative invasive abilities cells. Mechanistical analysis showed that acted miR-16-1-3p sponge MDM2 potential downstream target miR-16-1-3p. We further verified overexpression...
A recent Pairwise meta-analysis confirmed that circular RNA AGFG1 (circAGFG1) is abnormally highly expressed in breast cancer (BC) and may be associated with death risk. The purpose of this study was to elucidate the biological role circAGFG1 BC explore its potential downstream molecular mechanisms. CircAGFG1, miR-653-5p YWHAE expression tissues cells were analyzed by RT-qPCR or western blot. Gene regulated transfection plasmids oligonucleotides behaviors a series assays. ring structure...
Vascular calcification (VC) is usually associated with cardiovascular diseases (CVDs), which are one of the main causes mortality in world. This study aimed to analyze expression circular RNAs (circRNAs) patients VC and evaluate biomarkers for diagnosis VC.Calcified human aortic endothelial cells (HAECs) mouse aorta were detected by qRT-PCR. Subsequently, this was verified plasma coronary artery (CAC). The 40 control group 31 calcified quantitative reverse transcription polymerase chain...