A5084663302- Advanced biosensing and bioanalysis techniques
- Micro and Nano Robotics
- Modular Robots and Swarm Intelligence
- Advanced Materials and Mechanics
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Pharmacogenetics and Drug Metabolism
- Soft Robotics and Applications
- Genomics, phytochemicals, and oxidative stress
- Advanced Photocatalysis Techniques
- Natural product bioactivities and synthesis
- Phytochemistry and Bioactive Compounds
- Advanced Sensor and Energy Harvesting Materials
- Cervical and Thoracic Myelopathy
- SARS-CoV-2 detection and testing
- Advanced Nanomaterials in Catalysis
- Spine and Intervertebral Disc Pathology
- Carcinogens and Genotoxicity Assessment
- Drug-Induced Hepatotoxicity and Protection
- Conducting polymers and applications
- Phytochemical compounds biological activities
- Phytochemistry and Biological Activities
- Advancements in Transdermal Drug Delivery
- Photochromic and Fluorescence Chemistry
- Biosensors and Analytical Detection
Affiliated Hospital of Guizhou Medical University
2019-2025
University of Hong Kong
2023-2024
Soochow University
2019-2024
Hong Kong University of Science and Technology
2023-2024
City University of Hong Kong
2017-2024
Max Planck Institute of Colloids and Interfaces
2024
Guiyang Medical University
2019-2023
City University of Hong Kong, Shenzhen Research Institute
2018-2023
Guizhou University
2023
Kaili University
2022
Millirobots with magnetically drivable surfaces display a range of locomotive abilities and programmable behavior.
As a new type of transdermal drug delivery system (TDDS), microneedles have garnered significant attention for their noninvasiveness, portability, controllable administration, and wide-ranging loading capacity. While initially designed administration via the stratum corneum minimizing adverse reactions associated with systemic enhancing patient compliance, recently found applications in multitude medical contexts. Hence, potential transcends mere delivery. Recent reviews on extensively...
Abstract Microswimmers are considered promising candidates for active cargo delivery to benefit a wide spectrum of biomedical applications. Yet, big challenges still remain in designing the microswimmers with effective propelling, desirable loading and adaptive releasing abilities all one. Inspired by morphology biofunction spermatozoa, we report one-step formation strategy polymorphous sperm-like magnetic (PSMs) developing vortex turbulence-assisted microfluidics (VTAM) platform. The...
Developing small-scale soft continuum robots with large-angle steering capacity and high-precision manipulation offers broad opportunities in various biomedical settings. However, existing reach the bottleneck actuation on account of contradiction among small size, compliance actuation, large tender range, high precision, dynamic error. Herein, a 3D-printed millimeter-scale robot an ultrathin hollow skeleton wall (300 μm) inner-to-outer ratio (0.8) is reported. After coating thin...
A simple, dual-modular aptasensor for accurate determination of cardiac troponin I (cTnI), a sensitive biomarker acute myocardial infarction, is reported. It has the parallel output electrochemiluminescence (ECL) and electrochemical impedance spectroscopy (EIS) based on target-gated transportation signal probes (luminol/H2O2 or Fe(CN)63–/4–). The sensing capacity originated from amino-functionalized mouth margin nanochannels in vertically oriented mesoporous silica film, which was situ-grown...
Diabetic wounds severely influence life, facing grand challenges in clinical treatments. The demand for better treatment is growing dramatically. wound healing challenging because of inflammation, angiogenesis disruptions, and tissue remodeling. Based on sequencing results diabetic patients' skins artificial intelligence (AI)-assisted bioinformatics, we excavate a potential therapeutic agent Trichostatin A (TSA) target histone deacetylase 4 (HDAC4) healing. molecular docking simulation...
Abstract Modular robot that can reconfigure architectures and functions has advantages in unpredicted environment task. However, the construction of modular at small-scale remains a challenge since lack reliable docking detaching strategies. Here we report concept milli-scale cellular (mCEBOT) achieved by heterogeneous assembly two types units (short long units). Under magnetic field, proposed mCEBOT not only selectively assemble (e.g., end-by-end side-by-side) into diverse morphologies...
Two new MOFs based ECL aptasensors showed ultra-sensitivity towards the α-syn oligomer, an important biomarker for Parkinson's disease.
Bionic robot inspired by creatures in nature attracts attention from researchers due to its effective locomotion mode and high environment adaptability. Despite the recent achievements bionic research robotics, robots are almost simple morphology imitation. While imitation of functional texture microstructures also important, which always makes a significant difference performance robot. In this work, we proposed starfish milli soft with excellent locomotive great environmental Different...
Amyloid-β (Aβ) protein is considered to be a key biomarker that closely associated with Alzheimer's disease (AD). The level of Aβ, particularly its subtle fluctuation, indicates early neuropathological changes, which poses considerable challenge in predicting AD, considering the detection limit sensing technologies. Herein, new label-free sensor based on luminol electrochemiluminescence (ECL) was proposed by developing close-packed monolayered-SiO2 array gold (Au) nanoparticles (NPs)...
The unique motion styles of flagella and cilia (i.e., planar/helical waveform propulsion two-dimensional (2D)/three-dimensional (3D) asymmetric ciliary beating), play a key role in many biological activities inspire lots bionic designs, especially miniature robotic systems. However, quite different to the fact nature that microorganisms can evolve diverse motions from homologous bio-structure (9 + 2 axoneme structure), current bionics still not find an effective engineering solution achieve...
Abstract Untethered small robots with multiple functions show considerable potential as next‐generation catheter‐free systems for biomedical applications. However, owing to dynamic blood flow, even effective upstream swimming in vessels remains a challenge the robot, let alone performing medical tasks. This paper presents an untethered millirobot streamlined shape that integrates engine, delivery, and biopsy modules. Based on proposed spiral‐rolling strategy, this robot can move at...
As a substitute for traditional drug therapy, digital cognitive-behavioral therapy positively impacts the regulation of brain function, which can improve insomnia. However, there is currently paucity studies on cognitive behavioral as treatment To assess insomnia regarding its positive impact function. Participants were randomly assigned to either go/no-go group or dot-probe group. The primary outcome was quality sleep assessed by actigraphy monitoring bracelet, Pittsburgh index (PSQI),...
Dioscorea bulbifera L. (DBL) is a common traditional Chinese medicine, with diosbulbin B (DSB) as its main toxic component. DSB-derived cis-enedial (DDE), an electrophilic intermediate produced during the metabolic activation of DSB, reacts cysteine (Cys) and lysine (Lys) residues to form corresponding pyrrole derivative in proteins. Cys-modified proteins were identified using tandem mass tagging-activity-based protein profiling (TMT-ABPP). The modification hepatic acetyl-CoA acyltransferase...
Abstract Graft subsidence following anterior cervical reconstruction can result in the loss of sagittal balance and recurring foraminal stenosis. This study examined implant–endplate interface using a cyclic fatigue loading protocol an attempt to model seen vivo. The superior endplate from 30 vertebrae (C3 T1) were harvested biomechanically tested axial compression with one three implants: Fibular allograft; titanium mesh cage packed cancellous chips; trabecular metal. Each construct was...
Abstract Structured surfaces have attracted wide attention because of their great potential in directional transport, liquid collection or separation, microfluidics, etc. However, it remains a big challenge to design surface that can distinguish various liquids, utilize inherent properties control transportation, and realize functional applications. Herein, is presented an asymmetric soft‐structure (ASFS) with arrayed curvature units make the Laplace pressure as driving force determine...
The latent dangers of waterborne viral transmission have become a major public health concern. In this study, reduced graphene oxide (rGO)-Fe3O4 nanoparticles were decorated with cetyltrimethylammonium bromide (CTAB) to adsorb severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike pseudovirus and three human enteric viruses (HuNoV, HRV, HAdV). successful combination CTAB rGO-Fe3O4 was confirmed by electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy,...
The helical microstructure has been regarded as one of the essential geometrical shapes widely utilized in microelectromechanical systems (MEMS) and lab on chip systems. Different manufacture methods for microstructures attracted researchers' attention due to their respective advantages. Inspired by traditional machining techniques, this letter reports a new method accurate three-dimensional (3-D) based situ scanning electron microscope (SEM) nanorobotic manipulation system. Compared with...
Non-enzymatic electrochemical detection of glucose using Ni–Cu bimetallic alloy nanoparticles loaded on reduced graphene oxide through a one step synthesis strategy.