A5004178546- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Mental Health and Psychiatry
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Health and Mental Health
- Bipolar Disorder and Treatment
- Health, psychology, and well-being
- Psychiatric care and mental health services
- Obsessive-Compulsive Spectrum Disorders
- Healthcare Decision-Making and Restraints
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Monoclonal and Polyclonal Antibodies Research
- Infant Development and Preterm Care
- Autism Spectrum Disorder Research
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Health Systems, Economic Evaluations, Quality of Life
- T-cell and B-cell Immunology
- Autoimmune Neurological Disorders and Treatments
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Treatment and Access
- Child Nutrition and Feeding Issues
- Maternal Mental Health During Pregnancy and Postpartum
Norwegian University of Science and Technology
2016-2025
St Olav's University Hospital
2016-2025
NTNU Samfunnsforskning
2022-2025
Royal Academy of Arts
2024
Norwegian Medical Association
2020-2024
University of Bergen
2021-2023
Haukeland University Hospital
2023
Innsbruck Medical University
2023
University of Stavanger
2023
Stavanger University Hospital
2023
Abstract Background. Compulsory admission procedures of patients with mental disorders vary between countries in Europe. The Ethics Committee the European Psychiatric Association (EPA) launched a survey on involuntary 40 to gather information from all National Associations that are members EPA develop recommendations for improving processes and promote voluntary care. Methods. focused legislation admissions key actors involved procedure as well most common reasons admissions. Results. We...
Abstract Current guidelines for patients with schizophrenia spectrum disease do not take sex differences into account, which may result in inappropriate sex-specific treatment. In the BeSt InTro study, a total of 144 (93 men and 51 women) diagnosis ongoing psychosis were included randomized to amisulpride, aripiprazole, or olanzapine flexible dose. This trial is registered ClinicalTrials.gov (NCT01446328). Primary outcomes dose, dose-corrected serum levels, efficacy, tolerability. Dosing was...
OBJECTIVE: To examine psychiatric morbidity and overall functioning in adults born with low birth weight compared normal controls at age 26 years to study longitudinal trajectories of from early adolescence adulthood. METHODS: Prospective cohort wherein 44 preterm very (≤1500 g), 64 term small for gestational (SGA; <10th percentile), 81 control were examined using the MINI-International Neuropsychiatric Interview: M.I.N.I. Plus, Norwegian version, Global Assessment Functioning,...
There is growing evidence that the kynurenine pathway involved in pathology of diseases related to central nervous system (CNS), because neuroprotective or neurotoxic properties certain metabolites, yet role each metabolite not clear. The Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) currently under investigation, overlapping symptoms such as depression suggest CNS may be involved. These driven by enhanced neurotoxicity and/or diminished neuroprotection. However, status has been well...
Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) are both chronic disorders that have a devastating effect on the lives of affected patients their families. Both conditions overlapping clinical features partly resemble those inflammatory disorders. The etiology is still not understood, it suggested immune system might be contributing factor. So far, results inconclusive. purpose this study was to compare two investigate level marker high-sensitivity CRP (hsCRP) in CFS FM compared healthy...
We aimed to examine psychiatric symptoms in adults born preterm with very low birthweight or at term small for gestational age compared normal peers, and associations perinatal factors childhood motor cognitive function. In this longitudinal cohort study, one group (VLBW: ≤1500 g), term-born Small Gestational Age (SGA: <10th percentile) non-SGA control group, were assessed 26 years of age. Primary outcomes scores on self-reported questionnaires: Achenbach System Empirically Based Assessment...
Objectives To assess neurocognitive function in adults born with low birthweight compared controls and to explore associations between psychopathology these groups. Methods In this prospective cohort study, one group preterm very (VLBW: &lt;1,500 g , n = 53), small for gestational age at term (SGA: &lt;10th percentile, 63) term-born control (birthweight ≥10th 81) were assessed tests, diagnostic interviews, self-report questionnaires 26 years of age. Results The VLBW scored...
Suicide is a common cause of death in all phases schizophrenia spectrum disorder, particularly the youngest patients. Clinical measures have demonstrated limited value suicide prediction, spurring search for potential biomarkers. The causes suicidal behaviour are complex, but immune system seems to be involved as it reflects or even mental suffering. We aimed identify cytokines with associations suicidality sample patients symptoms active psychosis. Patients disorder (N = 144) participating...
Background: Use of restraint and finding the balance between security ethics is a continuous dilemma in clinical psychiatry. In daily clinic planning health-care service, knowledge on characteristics situations necessary to optimize its use avoid abuse.Methods: We describe pharmacological mechanical psychiatric acute wards hospital Middle Norway over an eight-year period. Data all cases from 2004 2011 were retrospectively collected hand-written protocols. Complementary information patients...
Knowledge on factors affecting mental health is pivotal to offer the appropriate help for patients referred services. Neurocognitive challenges affect a person's capacity cope in life. If underlying issues with cognitive functioning rather than psychiatric pathology cause suffering and failure function, other measures merely treatment may be needed. However, there lack of knowledge occurrence neurocognitive general outpatient population. This study included 283 outpatients Community Mental...
Abstract Introduction The patient activation measure–mental health (PAM-MH) scale, adapted from the Patient Activation Measure-13 Items (PAM-13) developed in United States, was designed to assess engagement and mental care. Despite initial validation of PAM-MH its original context, applicability other settings comparison gold standard PAM-13 remain unexplored. Furthermore, research addressing face construct validity is limited. This multi-phase study evaluated validity, reliability...
Abstract Background While several cross-sectional studies have suggested high burnout levels among health-care workers (HCW) during the Covid-19 pandemic, fewer examined longitudinal trajectories of burnout. Objectives To examine (1) change in Norwegian HCW a one-year period mid-phase pandemic (second, third, and fourth incidence rate peaks), (2) how demographic occupational variables, pandemic-related experiences (e.g., own infection, severe infection family, friend, or colleague, caring...
The prevalence of substance use in people acutely admitted to in-patient psychiatric wards is high and the patients` duration stay limited. Motivational interviewing a method with evidence based effect short interventions. aims present study were compare effects 2 sessions motivational treatment as usual (intervention group) only (control on adult patients comorbid emergency unit. This was an open randomised controlled trial including 135 where influenced admittance. After admission...
ABSTRACT Objective We examined whether anxiety and depression symptoms constitute increased risk of bloodstream infection (BSI), as a proxy for sepsis. Methods A general population with self-reported was followed prospectively hospital-verified BSI. Using multivariable Cox regression analysis, we estimated hazard ratios (HR) 95% confidence intervals (CI) BSI mortality, without statistical adjustment comorbidities, BMI, life-style factors that may confound or mediate the associations. Results...
Patients with schizophrenia have impaired physical health. However, evidence of how skeletal muscle force-generating capacity (FGC), a key component functional performance, may contribute to the impairment is scarce. Thus, aim this study was investigate patient groups' FGC and its association performance. Leg-press assessed along battery performance tests in 48 outpatients (28 men, 34 ± 10 years; 20 women, 36 12 years) spectrum disorder (ICD-10, F20-29), compared healthy age- gender-matched...
Depression occurs frequently in all phases of schizophrenia spectrum disorders. Altered activity the immune system is seen both depression and schizophrenia. We aimed to uncover depressive trajectories a sample 144 adult individuals with disorders followed for one year, order identify possible cytokine profile differences. Patients were assessed longitudinally Positive Negative Syndrome Scale (PANSS) Calgary Schizophrenia (CDSS), where score above 6 predicts depression. The serum...
The role of the immune system in pathogenesis Fibromyalgia (FM) and Chronic fatigue syndrome (CFS) is not clear. We have previously reported increased levels C-reactive protein (CRP) these patient groups compared to healthy controls wanted further explore circulating markers populations. population consisted three groups, 58 patients with FM, 49 CFS 54 controls. All participants were females aged 18-60. Patients recruited from a specialised university hospital clinic by advertisement among...
Abstract Background Referrals to specialised mental health care (such as community centres; CMHC) have increased over the last two decades. Patients often multifaceted problems, which cannot only be solved by such care. Resources are limited, and triaging is challenging. A novel method approaches patients early individually upon referral a CMHC—possibly with brief intervention—is an Early assessment Team (EaT). In EaT, therapists meet patient in process seek solve present problem, involving...
Schizophrenia is a serious mental disorder, and monitoring remission widely used measure of effectiveness the treatment provided. It very important to identify possible factors correlating with remission. In our substudy BeSt InTro, randomized controlled trial three antipsychotic drugs, 126 patients ICD-10 diagnoses F20-29 (F23 excluded) were one second-generation drugs amisulpride, aripiprazole or olanzapine. Remission rate was calculated at seven assessment points, without using time...
Particular syngeneic adjuvant-free monoclonal antibodies are immunogenic and elicit antibody responses against the variable region idiotypes (Ids). We here study how heavy-chain constant regions (C H ) regulate immune to Ids of free, uncomplexed antibodies. To this end, we selected two hybridomas, called Id 3 A.01 , that produce IgMλ2 directed toward 2,4,6-trinitrophenyl, subcloned rare IgG1, IgG3, IgE, or IgA class switch variants. The purified variants, which possessed their IgM...
Patients with schizophrenia are physically inactive and have high prevalence of cardiovascular disease (CVD). Peak oxygen uptake (V̇O 2peak ) is one the strongest predictors for CVD, yet rarely investigated in this patient population, how V̇O relates to other conventional CVD risk measures population unclear. We measured treadmill along daily physical activity assessed by triaxial accelerometry, body mass index (BMI), waist circumference, blood pressure, lipid profiles, glucose 48...
Although aerobic interval training (AIT) is recognized to attenuate the risk of cardiovascular disease (CVD) and premature mortality, it appears that rarely arrives at patients' doorsteps. Thus, this study investigated 1-year effects feasibility AIT delivered with adherence support in collaborative care outpatients schizophrenia. Forty-eight (28 men, 35 [31-38] (mean [95% confidence intervals]) years; 20 women, 36 [30-41] years) schizophrenia spectrum disorders (ICD-10) were randomized...