A5013753835- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Sports injuries and prevention
- Autism Spectrum Disorder Research
- Myofascial pain diagnosis and treatment
- Cholesterol and Lipid Metabolism
- Congenital heart defects research
- Renin-Angiotensin System Studies
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Nuclear Receptors and Signaling
- Hormonal Regulation and Hypertension
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Geology and Environmental Impact Studies
- Integrated Water Resources Management
- Biochemical Analysis and Sensing Techniques
- Education and Cultural Studies
- Family Support in Illness
- Low-power high-performance VLSI design
- Ubiquitin and proteasome pathways
- Genomics and Rare Diseases
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Cardiomyopathy and Myosin Studies
Medical University of Silesia
2016-2025
University of Silesia in Katowice
2024-2025
Górnośląskie Centrum Medyczne
2016-2024
Adam Mickiewicz University in Poznań
2011
The regenerative properties of platelet-rich plasma (PRP) result from the high concentration growth factors, including transforming factor beta 1 (TGF-β1). Nevertheless, this form therapy may not always be effective due to variability in genetic factors. In study, association TGFB1 gene polymorphisms with effectiveness lateral elbow tendinopathy (LET) treatment PRP was investigated. assessed using minimal clinically important difference (MCID) and patient-reported outcome measures (PROM),...
The aim of this study was to investigate whether the polymorphisms ADAMTS7 gene affect risk occurrence and mortality due CAD. group included 231 patients diagnosed with CAD 240 control blood donors. genotyping specified polymorphisms, i.e., rs1994016, rs3825807, rs7173743, performed using TaqMan-PCR. We found that C allele carriers rs1994016 A rs3825807 increased CAD, respectively: OR = 1.72, p 0.036; 1.64, 0.04. Moreover, we studied biological interactions variants, previously approved...
Individual differences in the response to platelet-rich plasma (PRP) therapy can be observed among patients. The genetic background may cause of this variability. current study focused on impact variants effectiveness PRP. aim present was analyze single nucleotide polymorphisms (SNP) platelet-derived growth factor receptor alpha (PDGFRA) gene treating lateral elbow tendinopathy (LET) with treatment's efficacy analyzed over time (2, 4, 8, 12, 24, 52 and 104 weeks after PRP injection) 107...
To analyze potential associations between three polymorphisms (rs3818188, rs941793, rs2403015) of the DYNC1H1 gene and occurrence autism spectrum disorder as well clinical phenotype affected individuals. This family-based study included 206 children diagnosed with ASD 364 their biological parents. examine association occurrence, a transmission disequilibrium test was performed. Additionally, studied individuals were analyzed using χ2 test. None showed an in overall patient group. However,...
The cholesteryl ester transfer protein (CETP) gene encodes a hydrophobic glycoprotein that plays crucial role in the reverse transport of cholesterol. aim present study was to determine whether CETP polymorphisms (rs1532624, rs247616 and rs708272) are associated with coronary artery disease (CAD) Polish population. Serum lipid levels single nucleotide genes were determined 494 subjects: 248 patients premature CAD 246 blood donors as controls. Selected examined using TaqMan PCR analysis. We...
The COL1A1 gene encodes the α1 chain of type I collagen, and data reported so far demonstrate that its polymorphic variants may affect biomechanical properties bones, muscles, tendons, contribute to musculoskeletal disorders. Given, however, limited research on these in tendon pathology, we analyzed impact polymorphisms tendinopathy phenotype effectiveness platelet-rich plasma (PRP) treatment for tennis elbow. Pain perception therapy outcomes were from baseline, i.e., before PRP injection...
There is variability in individual response to platelet-rich plasma (PRP) therapy tennis elbow treatment. Genetic variation, especially within genes encoding growth factors may influence the observed inter-individual differences. The purpose of this study was identify polymorphic variants platelet-derived factor beta polypeptide gene (PDGFB) that determine an improved PRP patients.This prospective cohort designed accordance with STROBE and MIBO guidelines. A 107 patients (132 elbows, 25...
Background: This study aims to identify genotype variants of the platelet-derived growth factor alpha polypeptide gene (PDGFA) that can influence individual response treatment with platelet-rich plasma (PRP) in tennis elbow patients. Methods: We observed a cohort 107 patients (132 elbows) who received PRP. Patients have been followed-up for two years after PRP injection and effectiveness was measured using universal patient-reported outcome measures (PROMs): visual analog scale (VAS), quick...
Differences in response to PRP (platelet-rich plasma) therapy may be linked the variability of growth factors and their receptor's genes. Considering that, we checked whether platelet-derived factor receptor beta gene (PDGFRB) single nucleotide polymorphisms (SNPs) affect effectiveness treating tennis elbow patients. The treatment efficacy was analyzed over time (2, 4, 8, 12, 24, 52, 104 weeks after injection) on 107 patients (132 elbows) using PROMs (patient-reported outcome measures),...
Vascular endothelial growth factor (VEGF) is implicated in both the etiology of tendinopathy and its healing process. Polymorphic variants VEGFA gene exhibit varied expression, which can influence phenotype treatment effectiveness. The aim present study was to analyze on effectiveness tennis elbow therapy using platelet-rich plasma (PRP), measured through common patient-reported outcome measures (PROMs). A cohort 107 patients (132 elbows) with prospectively analyzed, a two-year follow-up (at...
Platelet-rich plasma (PRP) is an autologous preparation used to accelerate regeneration; however, this form of therapy not always effective. Vascular endothelial growth factor B (
Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose present study was to determine whether PON1 gene rs854560 polymorphism (163T>A) associated with CAD in Polish population. genotyped 494 subjects: 248 patients premature 246 blood donors as a control. We found that risk significantly higher TT homozygotes than A allele carriers (OR = 1.87,<mml:math...
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Purpose. Single nucleotide polymorphisms of the CYBA gene may modify risk coronary artery disease (CAD). The aim present study was to investigate whether (⁎)49A>G (rs7195830) polymorphism is associated with CAD. Materials and Methods. determined in 481 subjects: 242 patients premature CAD 239 age sex matched controls using fluorescently labeled allele-specific oligonucleotides method. Results. frequency (⁎)49G allele carrier state significantly higher than (84.8% versus 76.6%, resp., P =...
Genetic factors can influence the risk of coronary artery disease (CAD) and survival patients. Our previous research led to identification genetic variants predisposing CAD in Polish population. Since many them affect clinical phenotype disease, aim this study was searching for potentially influencing patients with CAD. The included 276 hospitalized due disease. database medical history genotypic results 29 polymorphisms were used. endpoint defined as death from cardiovascular causes....
Platelet-rich plasma (PRP) therapy holds substantial promise for the treatment of tennis elbow, a complex and challenging musculoskeletal condition. The aim study was to assess whether there are correlations between levels individual morphotic elements determined in whole blood outcomes elbow with PRP injection, as measured using patient-reported outcome measures (PROMs) such Visual Analog Scale (VAS), Quick Disabilities Arm, Shoulder, Hand (QDASH), Patient-Rated Tennis Elbow Evaluation...
Padaczka lekooporna (<i>drug-resistant epilepsy</i> – DRE) u dzieci jest jedną z najczęściej diagnozowanych chorób układu nerwowego. Pomimo dostępności farmakoterapii o różnych mechanizmach działania lekooporność determinuje brak możliwości osiągnięcia zamierzonego efektu terapeutycznego. Mając na uwadze złożoną etiologię omawianej jednostki chorobowej, istnieje pilna potrzeba zgłębiania wiedzy w zakresie determinantów DRE, jak i poprawy jakości życia pacjentów oraz ich rodzin....
1. Wilczek-Rużyczka E, Kwak M. Zdrowie psychiczne. Współczesne zagrożenia i możliwości wzmocnienia. 1st ed. Warszawa: PZWL; 2022. p. 11. Google Scholar
Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed neurodevelopmental disorders. This article aims to identify risk factors for ADHD, with a particular focus on its genetic basis. The complex etiology ADHD results from interplay both environmental and factors, making it challenging pinpoint specific determinants contributing disorder’s phenotype. Among significant are genes regulating dopaminergic serotoninergic pathways. Genetic involved in various...
The aim of the study was to perform family-based association analysis PRKCB1, CBLN1 and KCNMB4 gene polymorphisms autism disorder. We comprised 206 Caucasian children with autistic spectrum disorder (ASD) their biological parents. In transmission/disequilibrium test we observed that T-allele rs198198 polymorphism PRKCB1 more often transmitted affected in male subgroup (p = 0.010). Additionally, T carrier state significantly associated hypotonia 0.048). female subgroup, carriers showed...
Background: The present study aimed to determine whether the polymorphisms of 11q23.3 locus affect risk and mortality coronary artery disease in 5-year 10-year observations. Methods: group consisted 519 subjects: 276 patients with CAD 243 blood donors as controls. genotyping (rs10750097, rs3741298, rs1729410) was performed using TaqMan-PCR method. Survival defined period from angiographic confirmation cardiovascular death, endpoint death causes. Results: G allele rs1729410 polymorphism...
Wstęp Wrodzone wady rozwojowe występują u ok. 2–4% noworodków. W Polsce od 1997 roku działa Polski Rejestr Wrodzonych Wad Rozwojowych, który pozwala na ich monitorowanie w populacji polskiej. Analiza regionalnych różnic częstości występowania wad wrodzonych może mieć istotne znaczenie poszukiwaniu czynników ryzyka oraz analizie działań profilaktycznych danym terenie. Celem niniejszej pracy była ocena urodzeń noworodków z wrodzonymi wadami rozwojowymi układu mięśniowo-szkieletowego...
Modele semantyczne są związane z programem logicznej rekonstrukcji wiedzy, a metody semantyki teoriomodelowej znalazły