The regenerative properties of platelet-rich plasma (PRP) result from the high concentration growth factors, including transforming factor beta 1 (TGF-β1). Nevertheless, this form therapy may not always be effective due to variability in genetic factors. In study, association TGFB1 gene polymorphisms with effectiveness lateral elbow tendinopathy (LET) treatment PRP was investigated. assessed using minimal clinically important difference (MCID) and patient-reported outcome measures (PROM),...

Hidradenitis suppurativa is a chronic disease that significantly reduces patients’ quality of life. Patients are chronically treated with systemic therapies, which often ineffective. Surgical treatment for severe cases hidradenitis one option affected patients. has its limitations, and wound closure may be particularly problematic. This requires the use reconstructive techniques. The methods choice split-thickness skin grafts or local flaps reconstructions. However, each method limitations....

(1) Introduction: Hidradenitis suppurativa (HS) is an inflammatory skin disease with recurrent, chronic, painful, and purulent lesions. Topical or systemic antibiotics are the most widely used treatments for management of mild stages disease. In chronic cases (Hurley II/III), wide excision lesions should be considered. During reconstructive surgery, problematic aspect wound closure. Very large excisional wounds require techniques such as flaps, grafts, both. Surgical methods have their...

The multifocality and multicentrality of breast cancer (MFMCC) are the significant aspects that determine a specialist's choice between applying breast-conserving therapy (BCT) or performing mastectomy. This study aimed to assess usefulness mammography (MG), contrast-enhanced spectral (CESM), magnetic resonance imaging (MRI) in women diagnosed with before qualifying for surgical intervention visualize other (additional) foci.

Background: Postmenopausal osteoporosis is not only related to hormonal factors but also associated with environmental and genetic factors. One of the latter polymorphism vitamin D receptor (VDR). The aim reported study was comprehensively analyze VDR gene polymorphic variants rs731236 (TaqI), rs1544410 (BsmI) rs7975232 (ApaI) in Polish population postmenopausal women. Methods: group consisted 611 women after menopause (their median age 65.82 ± 6.29 years). Each them underwent bone...

The aim of this study was to investigate whether the polymorphisms ADAMTS7 gene affect risk occurrence and mortality due CAD. group included 231 patients diagnosed with CAD 240 control blood donors. genotyping specified polymorphisms, i.e., rs1994016, rs3825807, rs7173743, performed using TaqMan-PCR. We found that C allele carriers rs1994016 A rs3825807 increased CAD, respectively: OR = 1.72, p 0.036; 1.64, 0.04. Moreover, we studied biological interactions variants, previously approved...

Individual differences in the response to platelet-rich plasma (PRP) therapy can be observed among patients. The genetic background may cause of this variability. current study focused on impact variants effectiveness PRP. aim present was analyze single nucleotide polymorphisms (SNP) platelet-derived growth factor receptor alpha (PDGFRA) gene treating lateral elbow tendinopathy (LET) with treatment's efficacy analyzed over time (2, 4, 8, 12, 24, 52 and 104 weeks after PRP injection) 107...

To analyze potential associations between three polymorphisms (rs3818188, rs941793, rs2403015) of the DYNC1H1 gene and occurrence autism spectrum disorder as well clinical phenotype affected individuals. This family-based study included 206 children diagnosed with ASD 364 their biological parents. examine association occurrence, a transmission disequilibrium test was performed. Additionally, studied individuals were analyzed using χ2 test. None showed an in overall patient group. However,...

Genetic variations in the COL1A1 and COL1A2 genes have been linked to bone mineral density (BMD) metabolic disorders. This study analyzed associations of (rs1107946, rs1800012) (rs42524) polymorphisms with BMD, obesity, type 2 diabetes (T2D) 554 postmenopausal women. Dual-energy X-ray absorptiometry assessed genotyping was performed alongside an evaluation lifestyle factors. The rs1107946 AA genotype associated higher femoral neck BMD (p < 0.05), over 10-fold increased obesity prevalence...

Drug-resistant epilepsies still remain one of the most profound problems contemporary epileptology. Several mechanisms drug resistance are possible; among them, genetic factors have a prominent place. Much importance is attached to genes, which encode enzymes that metabolize antiepileptic drugs CYP 3A, belong family cytochromes P450 and genome multidrug resistance, such as 1 (MDR1) expresses P-glycoprotein (P-gp), transporter protein. The aim study was assess relation between polymorphism...

The cholesteryl ester transfer protein (CETP) gene encodes a hydrophobic glycoprotein that plays crucial role in the reverse transport of cholesterol. aim present study was to determine whether CETP polymorphisms (rs1532624, rs247616 and rs708272) are associated with coronary artery disease (CAD) Polish population. Serum lipid levels single nucleotide genes were determined 494 subjects: 248 patients premature CAD 246 blood donors as controls. Selected examined using TaqMan PCR analysis. We...

(1) Background: Hidradenitis suppurativa is a disease that affects the intimacy of patients. This reduces quality life and functioning patients in everyday life. The surgical treatment HS one treatments for can improve (2) Methods: main goal this study was to assess before after at Center Burn Treatment Siemianowice Śląskie, Poland, using EQ-5D-5L survey operation follow-up (6 months after). (3) Results: average measured with therapy 39.3 ± 20.1 (min., 0; max., 60; most frequent value, 50),...

Cigarette smoking, hypercholesterolemia, and obesity influence the renin-angiotensin system (RAS) functions including an increased synthesis of angiotensin I converting enzyme (ACE). Thus in present work we explore interactions ACE gene insertion/deletion (I/D) polymorphism traditional risk factors. The study cohort included 341 subjects composed 172 patients with angiographically confirmed CAD 169 blood donors without a history cardiovascular diseases. I/D was genotyped using polymerase...

Reactive oxygen species (ROS) are involved in the pathogenesis of atherosclerosis and coronary artery disease (CAD). NADPH oxidases main source ROS vasculature. p22phox is a critical component vascular encoded by CYBA (cytochrome b245 alpha) gene. The −930A>G polymorphism (rs9932581:A>G) modulates activity promoter, influences transcriptional activity. aim present study was to analyze possible association between CAD search for gene–traditional risk factors interactions. 480 subjects were...

Hypercholesterolemia and cigarette smoking increase superoxide anion production, which is involved in many proatherosclerotic processes. NAD(P)H oxidases are the main source of superoxides vasculature, phagocyte oxidase (p22phox) encoded by CYBA gene a critical component oxidases. The 242T allele associated with an increased low-density lipoprotein oxidation production. This report focuses on interactions between C242T polymorphism traditional risk factors coronary artery disease (CAD), such...

Dairy products, a major source of calcium, demonstrate number beneficial effects, not only protecting against the development osteoporosis (OP) but also suppressing onset type-2 diabetes (T2DM) and improving bone mineral density (BMD). consumption is closely linked to lactose tolerance. One genetic factors predisposing individuals intolerance rs4988235 polymorphism MCM6 gene. The aim this reported study was analyse relationship between variant gene risk in women after menopause. Methods:...

The COL1A1 gene encodes the α1 chain of type I collagen, and data reported so far demonstrate that its polymorphic variants may affect biomechanical properties bones, muscles, tendons, contribute to musculoskeletal disorders. Given, however, limited research on these in tendon pathology, we analyzed impact polymorphisms tendinopathy phenotype effectiveness platelet-rich plasma (PRP) treatment for tennis elbow. Pain perception therapy outcomes were from baseline, i.e., before PRP injection...

7-Alpha cholesterol hydroxylase (CYP7A1), the first enzyme of classic conversion pathway leading from to bile acids synthesis, is encoded by CYP7A1 gene. Its single nucleotide polymorphisms (SNPs) influence serum lipid levels and may be related impaired profile coronary artery disease (CAD). The aim present study was analyze possible association between rs7833904 polymorphism premature CAD. Serum SNP were determined in 419 subjects: 200 patients with CAD 219 age sex matched controls. A...