Background: Postmenopausal osteoporosis is not only related to hormonal factors but also associated with environmental and genetic factors. One of the latter polymorphism vitamin D receptor (VDR). The aim reported study was comprehensively analyze VDR gene polymorphic variants rs731236 (TaqI), rs1544410 (BsmI) rs7975232 (ApaI) in Polish population postmenopausal women. Methods: group consisted 611 women after menopause (their median age 65.82 ± 6.29 years). Each them underwent bone...

Individual differences in the response to platelet-rich plasma (PRP) therapy can be observed among patients. The genetic background may cause of this variability. current study focused on impact variants effectiveness PRP. aim present was analyze single nucleotide polymorphisms (SNP) platelet-derived growth factor receptor alpha (PDGFRA) gene treating lateral elbow tendinopathy (LET) with treatment's efficacy analyzed over time (2, 4, 8, 12, 24, 52 and 104 weeks after PRP injection) 107...

The cholesteryl ester transfer protein (CETP) gene encodes a hydrophobic glycoprotein that plays crucial role in the reverse transport of cholesterol. aim present study was to determine whether CETP polymorphisms (rs1532624, rs247616 and rs708272) are associated with coronary artery disease (CAD) Polish population. Serum lipid levels single nucleotide genes were determined 494 subjects: 248 patients premature CAD 246 blood donors as controls. Selected examined using TaqMan PCR analysis. We...

The Review of Diabetic Studies,2007,4,4,231-235.DOI:10.1900/RDS.2007.4.231Published:February 2008Type:Short ReportAuthors:Jan Skupien, Grzegorz Kepka, Sylwia Gorczynska-Kosiorz, Anna Gebska, Tomasz Klupa, Krzysztof Wanic, Natalia Nowak, Maciej Borowiec, Jacek Sieradzki, and T Malecki Author(s) affiliations:Jan Skupien1, Kepka1, Gorczynska-Kosiorz2, Gebska3, Klupa1, Wanic1, Nowak1, Borowiec4, Sieradzki1 T. Malecki1 1Department Chair Metabolic Diseases, Jagiellonian University Medical College,...

1,5-anhydroglucitol (1,5-AG) is a short-term marker of metabolic control in diabetes. Its renal loss stimulated hyperglycemic conditions by glycosuria, which results lowered plasma concentration. As low threshold for glucose has been described hepatocyte nuclear factor-1alpha (HNF-1alpha) maturity-onset diabetes the young (MODY), 1,5-AG level may be altered these patients. The purpose this study was to assess levels patients with HNF-1alpha MODY and type 2 diabetic subjects similar degree...

I In nt tr ro od du uc ct ti io on n: : Transforming growth factor β1 (TGF-β1) is a cytokine involved in the process of pathological tissue sclerosis, which part pathophysiological mechanism end stage renal disease development.The aim study was to evaluate association single nucleotide polymorphism rs1800471 TGFB1 gene with chronic kidney (CKD) occurrence and progression as well hypertension appearance.M Ma at te er ri ia al l an nd d m me et th ho ds s: It case-control where 109 patients...

Reactive oxygen species (ROS) are involved in the pathogenesis of atherosclerosis and coronary artery disease (CAD). NADPH oxidases main source ROS vasculature. p22phox is a critical component vascular encoded by CYBA (cytochrome b245 alpha) gene. The −930A>G polymorphism (rs9932581:A>G) modulates activity promoter, influences transcriptional activity. aim present study was to analyze possible association between CAD search for gene–traditional risk factors interactions. 480 subjects were...

Dairy products, a major source of calcium, demonstrate number beneficial effects, not only protecting against the development osteoporosis (OP) but also suppressing onset type-2 diabetes (T2DM) and improving bone mineral density (BMD). consumption is closely linked to lactose tolerance. One genetic factors predisposing individuals intolerance rs4988235 polymorphism MCM6 gene. The aim this reported study was analyse relationship between variant gene risk in women after menopause. Methods:...

aturity-onset diabetes of the young (MODY) is an autosomaldominant form disease characterized by ␤-cell defects and early age diagnosis.So far, six MODY genes have been identified (1,2).MODY sometimes accompanied extrapancreatic features such as developmental malformations physiological biochemical abnormalities (3).The most frequent MODY3 subtype caused mutations in hepatocyte nuclear factor (HNF)-1␣ gene, a transcription expressed pancreas, kidney, liver, gut. RESEARCH DESIGN AND...

7-Alpha cholesterol hydroxylase (CYP7A1), the first enzyme of classic conversion pathway leading from to bile acids synthesis, is encoded by CYP7A1 gene. Its single nucleotide polymorphisms (SNPs) influence serum lipid levels and may be related impaired profile coronary artery disease (CAD). The aim present study was analyze possible association between rs7833904 polymorphism premature CAD. Serum SNP were determined in 419 subjects: 200 patients with CAD 219 age sex matched controls. A...

There is variability in individual response to platelet-rich plasma (PRP) therapy tennis elbow treatment. Genetic variation, especially within genes encoding growth factors may influence the observed inter-individual differences. The purpose of this study was identify polymorphic variants platelet-derived factor beta polypeptide gene (PDGFB) that determine an improved PRP patients.This prospective cohort designed accordance with STROBE and MIBO guidelines. A 107 patients (132 elbows, 25...

Background: This study aims to identify genotype variants of the platelet-derived growth factor alpha polypeptide gene (PDGFA) that can influence individual response treatment with platelet-rich plasma (PRP) in tennis elbow patients. Methods: We observed a cohort 107 patients (132 elbows) who received PRP. Patients have been followed-up for two years after PRP injection and effectiveness was measured using universal patient-reported outcome measures (PROMs): visual analog scale (VAS), quick...

Differences in response to PRP (platelet-rich plasma) therapy may be linked the variability of growth factors and their receptor's genes. Considering that, we checked whether platelet-derived factor receptor beta gene (PDGFRB) single nucleotide polymorphisms (SNPs) affect effectiveness treating tennis elbow patients. The treatment efficacy was analyzed over time (2, 4, 8, 12, 24, 52, 104 weeks after injection) on 107 patients (132 elbows) using PROMs (patient-reported outcome measures),...

Vascular endothelial growth factor (VEGF) is implicated in both the etiology of tendinopathy and its healing process. Polymorphic variants VEGFA gene exhibit varied expression, which can influence phenotype treatment effectiveness. The aim present study was to analyze on effectiveness tennis elbow therapy using platelet-rich plasma (PRP), measured through common patient-reported outcome measures (PROMs). A cohort 107 patients (132 elbows) with prospectively analyzed, a two-year follow-up (at...

Background: Variants in fat mass and the obesity-associated protein (FTO) gene have long been recognized as most significant genetic predictors of body obesity. Nevertheless, despite overall evidence, there are conflicting reports regarding correlation between different polymorphisms FTO index (BMI). Additionally, it is unclear whether influences metabolic syndrome (MetS) through mechanisms other than BMI’s impact. In this work, we aimed to analyze impact following on BMI well MetS...

Recently, genome-wide association studies have revealed a locus associated with coronary artery disease (CAD) and myocardial infarction, namely, 9p21.3. Its participation in the conditioning of has been proven many populations European descent, but not yet Slavs. Allelic variants rs10757278 polymorphism functionally affect activity 9p21.3 locus; therefore, we conducted study to determine whether is premature CAD Polish patients. We studied 320 subjects aged 25–55 years, divided into two...

The COL1A1 gene encodes the α1 chain of type I collagen, and data reported so far demonstrate that its polymorphic variants may affect biomechanical properties bones, muscles, tendons, contribute to musculoskeletal disorders. Given, however, limited research on these in tendon pathology, we analyzed impact polymorphisms tendinopathy phenotype effectiveness platelet-rich plasma (PRP) treatment for tennis elbow. Pain perception therapy outcomes were from baseline, i.e., before PRP injection...

Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose present study was to determine whether PON1 gene rs854560 polymorphism (163T&gt;A) associated with CAD in Polish population. genotyped 494 subjects: 248 patients premature 246 blood donors as a control. We found that risk significantly higher TT homozygotes than A allele carriers (OR = 1.87,<mml:math...

Single nucleotide polymorphisms (SNPs) of the USF1 gene (upstream stimulatory factor 1) influence plasma lipid levels. This study aims to determine whether SNPs interact with traditional risk factors atherosclerosis increase coronary artery disease (CAD) risk. In present serum levels and (rs2516839 rs3737787) were determined in 470 subjects: 235 patients premature CAD controls. A trend increasing triglycerides (TG) relation C allele dose rs2516839 SNP was observed. The synergistic effect...

Abstract Aims Only one‐third of Type 1 diabetes patients develop diabetic nephropathy, and a genetic predisposition is postulated. To obtain more insight into processes that lead to messenger RNA expression profiles peripheral blood mononuclear cells from with without nephropathy were compared. Methods We studied seven male proteinuria 12 normoalbuminuria after at least 20 years duration. The genes was examined using the microarray method Human Genome U133A Arrays (Affymetrix, Santa Clara,...

Multifactorial pathogenesis of diabetic kidney disease (DKD) consists a combination metabolic, environmental, and genetic factors. A genome-wide association study has shown that ELMO1 is candidate gene for DKD occurrence progression. The aim this was to assess the single nucleotide polymorphism (rs741301) with in Polish patients type 2 diabetes (T2DM).This case/control 272 T2DM or without DKD. Patients were divided into groups depending on definition according American Diabetes Association...

The worldwide growing burden of diabetes and end-stage renal disease due to diabetic nephropathy has become the reason for research looking a single marker chronic kidney development progression that can be found in early stages disease, when preventive action delaying destructive process could performed. aim study was investigate influence rs3807337 polymorphism caldesmon 1 (CALD1) gene located on long arm chromosome 7 encoding protein is connected with physiological function...