A5102983473- Advanced Glycation End Products research
- Connective Tissue Growth Factor Research
- Glycosylation and Glycoproteins Research
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Extracellular vesicles in disease
- Connective tissue disorders research
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Circular RNAs in diseases
- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Pulmonary Hypertension Research and Treatments
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- MicroRNA in disease regulation
- Systemic Sclerosis and Related Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Nutrition and Health in Aging
- Bone Metabolism and Diseases
- Diabetes Treatment and Management
- Advanced Biosensing Techniques and Applications
Zhongda Hospital Southeast University
2015-2024
Southeast University
2007-2023
China Pharmaceutical University
2019-2022
Affiliated Hospital of Jiangsu University
2013
Jiangsu University
2013
Zhongshan Hospital
2011
Nanjing Medical University
2006-2010
Jiangsu Province Hospital
2010
Tianjin Fourth Central Hospital
2006
Nanjing Institute of Railway Technology
1999
Advanced glycation end-products (AGEs) are elevated under diabetic conditions and associated with insulin resistance, endothelial dysfunction vascular inflammation in humans. It has been demonstrated that AGEs evoke oxidative inflammatory reactions cells through the interaction a receptor for (RAGE). Here, we aimed to identify cellular mechanisms by which exacerbate human coronary artery (HCAECs). 30 type 2 patients or without atherosclerosis were recruited this study. Plasma levels of AGE...
Abstract Atherosclerosis is a progressive inflammatory disease characterised by excessive lipid accumulation and cell infiltration the basis of most cardiovascular diseases peripheral arterial diseases. Therefore, an effectively targeted delivery system urgently needed to deliver ferroptosis‐specific inhibitors site plaque microenvironment. Inspired fact that neutrophils can be recruited plaques under action adhesion molecules chemokines, authors developed neutrophil membrane hybrid liposome...
Connective tissue growth factor (CTGF) has been identified as playing critical roles in fibrosis and is a promising therapeutic target. In previous study, we used phage display library to develop humanized single-chain variable fragment antibody (scFv) against CTGF. the present protective effect of anti-CTGF scFv bleomycin (BL)-induced pulmonary was investigated mice.The expression α-smooth muscle actin human embryonic lung fibroblast (HELF) cells analysed by western blotting. A mouse model...
Background The osteogenic differentiation of vascular smooth muscle cell (VSMCs) is important for the development calcification (VC), particularly in diabetes. Exosomes derived from Mesenchymal Stromal Cells (MSCs) are effective against cardiovascular diseases, yet their role VC remains unclear. Advanced glycation end products (AGEs) inhibit bone marrow stromal osteogenesis by targeting osteogenesis-associated genes. Thus, we investigated exosomes MSCs pretreated with AGE-BSA and its...
Long non-coding RNA (lncRNA) plays important roles in many diseases, including pulmonary hypertension. The anti-diabetic drug metformin has been discovered to have protective effect on experimental artery hypertension (PAH). However, the exact mechanism of expression lncRNA PAH remains unclear. Here, we applied microarray analysis examine and mRNA proflies arteries (PAs) tissues rats with or without treatment. A total 24 lncRNAs (14 upregulated 10 down-regulated) 82 mRNAs (17 65 were...
Background Growing studies have shown that insulin resistance (IR) is associated with poor prognoses among patients diabetes, whereas the association between IR and mortality has not been determined. Hence we aimed to evaluate associations all-cause, cardiovascular diseases (CVDs) cancer-related in diabetes. Methods We enrolled 2,542 participants diabetes an average age of 57.12 ± 0.39 years 52.8% men from 1999–2014 National Health Nutrition Examination Survey (NHANES 1999–2014). A novel...
Receptor for advanced glycation end products (RAGE) was studied in different stages of carbon tetrachloride induced hepatic fibrosis (HF), and effect its gene silencing the HF development evaluated rats. Silencing RAGE expression by specific siRNA effectively suppressed NF-κB activity, stellate cell activation, accumulation extracellular matrix proteins fibrotic liver, also greatly improved histopathology ultra-structure liver cells. These effects may be partially mediated inhibition on IκBα...
Abstract Background High fasting plasma glucose (HFPG) is the fastest-growing risk factor for cancer deaths worldwide. We reported mortality attributable to HFPG at global, regional, and national levels over past three decades associations with age, period, birth cohort. Methods Data this study were retrieved from Global Burden of Disease Study 2019, we used age-period-cohort modelling estimate cohort period effects, as well net drift (overall annual percentage change) local (annual change...
Cardiovascular disease (CVD) is a leading cause of mortality and morbidity among patients with diabetes. Endothelial dysfunction an early physiological event in CVD. Metformin, common oral antihyperglycemic agent, has been demonstrated to directly affect endothelial cell function. Brain-derived neurotrophic factor (BDNF), originally discovered the brain as neurotrophin, also reported play protective role cardiovascular system. In our study, we that high glucose (HG) reduced proliferation...
Background Nε-carboxymethyl-lysine (CML) is a major advanced glycation end-product (AGEs) widely found in foods. The aim of our study was to evaluate how exogenous CML-peptide dynamically absorbed from the gastrointestinal tract and eliminated by renal tubular secretion using microPET imaging. Methods present consisted three investigations. In I, we synthesized imaging tracer 18F-CML reacting N-succinimidyl 4-18F-fluorobenzoate (18F-SFB) with CML. II, biological activity evaluated RAW264.7...
Abstract There is an inseparable link between bone metabolism and gut microbiota, the supplementation of probiotics exhibits a significant role in maintaining homeostasis microbiota inhibiting loss. This study aims to explore preventive therapeutic potentials specific mechanisms Rothia on osteoporosis. The mice models osteoporosis induced by ovariectomy (OVX) were built, regular (once day) quantitative (200 μL/d) gavage was performed for 8 weeks starting from 1 week after OVX. Microcomputed...
Exercise induces a number of benefits, including angiogenesis in post‑myocardial infarction (MI); however, the underlying mechanisms have not been fully clarified. Neurotrophic brain‑derived neurotrophic factor (BDNF) serves protective role certain adult cardiac diseases through its specific receptor, BDNF/NT‑3 growth factors receptor (TrkB). The present study explored by which exercise improves function, with focus on involvement BDNF/TrkB axis. MI rats were assigned to Sham, sedentary,...
Hyperglycemia is a rapidly increasing risk factor for cancer mortality worldwide. However, the dose‒response relationship between glucose levels and all-cause in survivors still uncertain. We enrolled 4,491 (weighted population 19,465,739) from 1999–2019 National Health Nutrition Examination Survey (NHANES). Cancer were defined based on question of whether they had ever been diagnosed with by doctor or health professional. Hemoglobin A1c (HbA1c) was selected this study as stable marker...
Connective tissue growth factor (CTGF) plays a crucial role in the formation and development of hepatic fibrosis. The aim this study was to establish method for CTGF determination order investigate level sera patients with hepatitis B virus, assess correlation between concentration stage A C-terminal region gene obtained by RT-PCR human mesangial kidney cells inserted into pET-32a(+) vector. Recombinant protein expression purification fused protein. Polyclonal monoclonal antibodies were...
Abstract Purpose This study was designed to investigate the awareness of pharmacovigilance by healthcare professionals in Jiangsu, China. Methods carried out 62 hospitals Jiangsu province, China, between May and August, 2007, using a closed choice questionnaire. The data were entered EpiData3.1 software analyzed χ 2 ‐test, single‐factor analysis, multi‐factor logistic regression SAS9.1 software. Result A total 2361 questionnaires suitable completeness for statistical analyses. participants...