A5070477710- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Renal cell carcinoma treatment
- Management of metastatic bone disease
- Colorectal Cancer Treatments and Studies
- Tumors and Oncological Cases
- Cancer Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Colorectal and Anal Carcinomas
- Congenital Diaphragmatic Hernia Studies
- Urinary and Genital Oncology Studies
- Drug-Induced Ocular Toxicity
- Neurological and metabolic disorders
- Urological Disorders and Treatments
- Intestinal and Peritoneal Adhesions
- Lung Cancer Treatments and Mutations
PAMM
2014-2024
Catharina Ziekenhuis
2019-2024
Radboud University Nijmegen
2019-2024
Eurofins (Netherlands)
2024
Amsterdam University Medical Centers
2022
Amsterdam UMC Location University of Amsterdam
2018
Maastricht University
2010-2013
Maastricht University Medical Centre
2007-2013
Atrium Medisch Centrum Parkstad
2010
Epithelioid hemangioendothelioma is a malignant, often indolent vascular tumor which occurs at various anatomic sites. Based on reciprocal translocation t (1;3)(p36;q25), consistent WWTR1-CAMTA1 fusion gene has been found. An alternate YAP1-TFE3 detected in small and distinct subset of cases.Thirty-nine tumors, from 24 females 15 males with an age range 9-85 years, were located soft tissue (head neck [8], trunk [5], upper extremities [3], lower [2], mediastinal [1], paratesticular [1]),...
After endoscopic resection (ER) of early esophageal adenocarcinoma (EAC), the optimal management patients with high-risk histologic features for lymph node metastases (ie, submucosal invasion, poor differentiation grade, or lymphovascular invasion) remains unclear. We aimed to evaluate outcomes follow-up after ER EAC.For this retrospective cohort study, data were collected from all Dutch managed (endoscopy, EUS) EAC between 2008 and 2019. distinguished 3 groups: intramucosal cancers...
Abstract Background: Barrett's esophagus (BE) is a precursor lesion of esophageal adenocarcinoma. Besides gastroesophageal reflux, possible risk factors for BE include overweight, cigarette smoking, and alcohol consumption. Our objective was to study these associations by using prospective data. Methods: The Netherlands Cohort Study, initiated in 1986, consists 120,852 men women, aged 55 69 years at baseline. At baseline, all subjects completed questionnaire on dietary habits lifestyle....
Abstract Tumor‐derived cell‐free DNA (cfDNA) is an emerging biomarker for guiding the personalized treatment of patients with metastatic colorectal cancer (CRC). While CRC liver metastases (CRC‐LM) have relatively high levels plasma cfDNA, little known about peritoneal (CRC‐PM). This study evaluated presence tumor‐derived cfDNA in and fluid (i.e. ascites or washing) 20 isolated CRC‐PM 100 CRC‐LM. Among tumor tissue KRAS/BRAF mutation carriers, was detected by droplet digital polymerase chain...
Aims Interobserver agreement for dysplasia in Barrett's oesophagus (BO) is low, and guidelines advise expert review of dysplastic cases. The aim this study was to assess the added value p53 immunohistochemistry (IHC) homogeneity within a group dedicated gastrointestinal (GI) pathologists. Methods results Sixty‐single haematoxylin eosin (HE) slide referral BO cases [20 low‐grade (LGD); 20 high‐grade (HGD); non‐dysplastic reference cases] were digitalised independently assessed twice random...
There are few epidemiological data on the dietary risk factors of Barrett's oesophagus, a precursor oesophageal adenocarcinoma. The present study investigated association between vegetable, fruit and nitrate intake oesophagus in large prospective cohort. Netherlands Cohort Study recruited 120 852 individuals aged 55–69 years 1986. Vegetable was assessed using 150-item FFQ, from sources drinking water determined. After 16·3 follow-up, 433 cases (241 men 192 women) with specialised intestinal...
Introduction Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy with oxaliplatin (ePIPAC-OX) is offered as a palliative treatment option for patients isolated unresectable colorectal peritoneal metastases (PM) in several centres worldwide. However, little known about its feasibility, safety, tolerability, efficacy, costs and pharmacokinetics this setting. This study aims to explore these parameters PM who receive repetitive ePIPAC-OX monotherapy. Methods analysis...
Huysentruyt C J R, Baldewijns M M, Rüland A Tonk R W, Vervoort P S Smits K van de Beek & Speel E-J M(2011) Histopathology 58, 1048–1053Modified UroVysion scoring criteria increase the urothelial carcinoma detection rate in cases of equivocal urinary cytology Aims: UroVysion® is a four-target fluorescence situ hybridization technique for (UC) cytology. The aim this retrospective study was to investigate UC modified test patients with modification comprised addition cytological prescreening...
Dysplasia assessment of Barrett's esophagus biopsies is associated with low observer agreement; guidelines advise expert review. We have developed a web-based review panel for dysplastic biopsies.The purpose this study was to test if 10 gastrointestinal pathologists working at Dutch centres met pre-set benchmark scores quality criteria.Ten twice assessed 60 digitalized cases, enriched dysplasia; then randomised (7520 assessments). tested predefined criteria: (a) percentage 'indefinite...
Endoscopic resection (ER) is an important diagnostic step in management of patients with early Barrett's esophagus (BE) neoplasia. Based on ER specimens, accurate histological diagnosis can be made, which guides further treatment. depth tumor invasion, differentiation grade, lymphovascular and margin status, the risk lymph node metastases local recurrence judged to low enough justify endoscopic management, or high warrant invasive surgical esophagectomy. Adequate assessment these factors...
To investigate the association between selenium and risk of Barrett's esophagus (BE), precursor lesion esophageal adenocarcinoma.Data from prospective Netherlands Cohort Study were used. This cohort study was initiated in 1986, when 120,852 subjects aged 55-69 years completed a questionnaire on dietary habits lifestyle, provided toenail clippings for determination baseline status. After 16.3 follow-up, 253 BE cases (identified through linkage with nationwide Dutch pathology registry) 2,039...
Aims The histopathological diagnosis of low-grade dysplasia (LGD) in Barrett’s oesophagus (BO) is associated with poor interobserver agreement and guidelines dictate expert review. To facilitate nationwide review the Netherlands, a web-based digital panel has been set up, which currently consists eight ‘core’ pathologists. aim this study was to evaluate if other pathologists from Dutch BO centres qualify for by assessing their performance 80 consecutive LGD reviews submitted panel. Methods...
Introduction Despite its increasing use, first-line palliative systemic therapy alternated with electrostatic pressurised intraperitoneal aerosol chemotherapy oxaliplatin (ePIPAC-OX), hereinafter referred to as bidirectional therapy, has never been prospectively investigated in patients colorectal peritoneal metastases (CPM). As a first step address this evidence gap, the present study aims assess safety, feasibility, antitumour activity, patient-reported outcomes, costs and pharmacokinetics...
Abstract Background: Increasing meat intake and its possible role in the development of esophageal adenocarcinoma raises question whether consumption is associated with premalignant lesion, Barrett's esophagus. Methods: Associations between risk esophagus consumption, N-nitrosodimethylamine, nitrite, heme iron were examined Netherlands Cohort Study among 120,852 subjects aged 55 to 69 years 1986. Exposure was measured on basis a 150-item food frequency questionnaire. After 16.3 follow-up,...
Large biobanks with uniform collection of biomaterials and associated clinical data are essential for translational research. The Netherlands has traditionally been well organized in multicenter research on pancreatic diseases, including the nationwide multidisciplinary Dutch Pancreatic Cancer Group Pancreatitis Study Group. To enable high-quality periampullary these groups established Pancreas Biobank.The Biobank is part Parelsnoer Institute involves all 8 university medical centers 5...
Currently data on the risk of progression to and lifetime cancer are not available for patients with young onset Barrett's esophagus (BE). Our aim was obtain epidemiologic incidence dysplasia or adenocarcinoma in BE Netherlands by collecting all histologically confirmed cases over a prolonged period 25 years between January 1, 1991 December 31, 2015.