A5063354227- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Management of metastatic bone disease
- Nanoparticle-Based Drug Delivery
- Neuroendocrine Tumor Research Advances
- Anesthesia and Pain Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 diagnosis using AI
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Uterine Myomas and Treatments
- Muscle and Compartmental Disorders
- Cancer Risks and Factors
- Multiple and Secondary Primary Cancers
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
Radboud University Nijmegen
2021-2025
Catharina Ziekenhuis
2021-2025
University of Amsterdam
2020
Amsterdam University Medical Centers
2020
To determine the yield of preoperative screening for COVID-19 with chest CT and RT-PCR in patients without symptoms.Many centers are currently surgical using either CT, or both, due to risk worsened outcomes nosocomial spread. The optimal design such a strategy unknown.This multicenter study included consecutive adult symptoms who underwent before elective emergency surgery under general anesthesia.A total 2093 were 14 participating centers; 1224 screened by 869 only. positive combination...
Whereas neoadjuvant chemo(radio)therapy is increasingly used in pancreatic cancer, it currently not recommended for other periampullary (non-pancreatic) cancers. This has important implications the relevance of preoperative diagnosis pancreatoduodenectomy. retrospective multicentre cohort study aimed to determine frequency clinically relevant misdiagnoses patients undergoing pancreatoduodenectomy or cancer.Data from all consecutive who underwent a between 2014 and 2018 were obtained...
3505 Background: In patients with resectable colorectal peritoneal metastases who qualify for cytoreductive surgery hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), there is no prospective data comparing the efficacy of perioperative systemic therapy CRS-HIPEC alone. Methods: this multicenter phase 3 superiority trial, without extraperitoneal did not receive within six months prior to enrollment were randomly assigned (1:1) CAPOX, FOLFOX, or FOLFIRI neoadjuvant addition bevacizumab...
Purpose: To assess the safety and long-term outcome of a multimodality treatment consisting radical surgery, intra-operative radiotherapy (IORT), cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for patients locally advanced rectal cancer (LARC) or recurrent carcinoma (LRRC) peritoneal metastases (PM). Methods: The present study was single-center cohort study, including all consecutive undergoing this in tertiary referral center LARC, LRRC, PM. Postoperative...
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival outcomes for selected patients colorectal peritoneal metastases (PM), but recurrence rates are high. The aim of this study was to develop a tool predict in PM that undergo CRS-HIPEC.
Limited data are available to guide the decision-making process for clinicians and their patients regarding palliative treatment options with isolated synchronous colorectal cancer peritoneal metastases (CRC-PM). Therefore, aim of this study is analyze outcome different treatments these patients. All diagnosed CRC-PM between 2009 2020 (Netherlands Cancer Registry) who underwent were included. Patients emergency surgery or curative intent excluded. categorized into upfront primary tumor...
Introduction The peritoneum is the second most affected organ for dissemination of colorectal cancer (CRC). Patients with peritoneal metastases (CPM) face a poor prognosis, despite majority patients being treated palliative systemic therapy. efficacy therapy limited due to plasma-peritoneum barrier. prognosis unresectable CPM has resulted in development new treatment strategies where combined local, intraperitoneal chemotherapy. In recently published phase I study, maximum tolerated dose and...
Peritoneal metastases (PMs) from colorectal cancer (CRC) respond poorly to treatment and are associated with unfavorable prognosis. For example, the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) cytoreductive surgery in resectable patients shows limited benefit, novel treatments urgently needed. The majority CRC-PMs represent CMS4 molecular subtype CRC, here we queried vulnerabilities this pharmacogenomic databases identify therapies. This reveals copper ionophore elesclomol...
Purpose—To compare patient-reported outcomes (PROs) of patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for colorectal peritoneal metastases to PROs cancer (CRC) conventional surgery. Methods—Data were extracted from the CAIRO6 trial (CRS-HIPEC group) PROCORE study (conventional group). Nine predefined (derived EORTC QLQ-C30 questionnaire) compared at baseline, in early postoperative period one year postoperatively, with correction treatment...
Obesity is a major global health problem and an important risk factor for colorectal cancer (CRC) increased body weight. plays role in the peritoneal dissemination of cancer; however, it unclear whether this also applies CRC. The purpose study was to provide insight obesity on cancer.Of all patients diagnosed with CRC Netherlands first half 2015, follow-up data completed 2019. Weight at time primary diagnosis categorized as underweight, normal weight, overweight, or obese. Logistic...
Oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy (PIPAC-OX) is an emerging palliative treatment for patients with unresectable colorectal peritoneal metastases. Previously, our study group reported that experienced abdominal pain several weeks after PIPAC-OX. However, it unknown how this compares to regular cancer surgery. To provide some perspective, compared the presence of PIPAC-OX primary tumor Patient scores (EORTC QLQ-CR-29), from two prospective, Dutch cohorts were...
Introduction Despite optimal patient selection and surgical effort, recurrence is seen in over 70% of patients undergoing cytoreductive surgery (CRS) for peritoneal metastases (PM). Apart from the Peritoneal Cancer Index (PCI), completeness cytoreduction tumour grade, there are other factors like disease distribution cavity, pathological response to systemic chemotherapy (SC), lymph node morphology PM which may have prognostic value. One reason underutilisation these that they known only...
The CRC-PIPAC-II study prospectively assessed bidirectional therapy (BT) consisting of first-line palliative systemic and electrostatic precipitation oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy (ePIPAC-OX) in patients with unresectable colorectal peritoneal metastases (CPM). This describes the exploration patient-reported outcomes (PROs).
Abstract Introduction Despite optimal patient selection and surgical effort, recurrence is seen in over 70% of patients undergoing cytoreductive surgery(CRS) for peritoneal metastases (PM). Apart from the cancer index(PCI), completeness cytoreduction tumor grade, there are other factors like disease distribution cavity, pathological response to systemic chemotherapy(SC), lymph node morphology PM which may have prognostic value. One reason underutilization these that they known only after...