A5086012730- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Hedgehog Signaling Pathway Studies
- Pelvic and Acetabular Injuries
- Orthopedic Infections and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related Molecular Pathways
- Genomic variations and chromosomal abnormalities
- Orthopedic Surgery and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Musculoskeletal pain and rehabilitation
- Bone Metabolism and Diseases
- Bone health and treatments
- Shoulder Injury and Treatment
- Muscle and Compartmental Disorders
- Case Reports on Hematomas
- Elbow and Forearm Trauma Treatment
- Pediatric Pain Management Techniques
- Bone health and osteoporosis research
- Urological Disorders and Treatments
- Foot and Ankle Surgery
- Medical and Biological Sciences
- Inflammatory mediators and NSAID effects
Harvard University
2019-2025
Beth Israel Deaconess Hospital
2016-2025
Beth Israel Deaconess Medical Center
2018-2024
Hadassah Medical Center
2022-2023
Creative Commons
2022
American Academy of Orthopaedic Surgeons
2022
University of Massachusetts Chan Medical School
1999-2014
Mayo Clinic
2010
University of Massachusetts Amherst
2010
UMass Memorial Medical Center
2008
Brox, W. Timothy MD; Roberts, Karl C. Taksali, Sudeep Wright, Douglas G. Wixted, John J. Tubb, Creighton Patt, Joshua Templeton, Kimberly Dickman, Eitan Adler, Robert A. Macaulay, William B. Jackman, James M. DO; Annaswamy, Thiru Adelman, Alan MD, MS; Hawthorne, Catherine Olson, Steven Mendelson, Daniel Ari LeBoff, Meryl S. Camacho, Pauline MACE; Jevsevar, David MBA; Shea, Kevin Bozic, Shaffer, Cummins, Deborah PhD; Murray, Jayson N. MA; Donnelly, Patrick Shores, Peter MPH; Woznica, Anne...
This article presents a unified clinical theory that links established facts about the physiology of bone and homeostasis, with those involved in healing fractures development nonunion. The key to this is concept tissue forms around fracture should be considered specific functional entity. 'bone-healing unit' produces physiological response its biological mechanical environment, which leads normal bone. responds forces functions according Wolff's law, Perren's strain Frost's "mechanostat"....
Runx2, required for bone formation, is ectopically expressed in breast cancer cells. To address the mechanism by which Runx2 contributes to osteolytic disease induced MDA-MB-231 cells, we investigated effect of on key components "vicious cycle" transforming growth factor beta (TGFbeta)-mediated tumor and osteolysis. We find that directly up-regulates Indian Hedgehog (IHH) colocalizes with Gli2, a signaling molecule. These events further activate parathyroid hormone-related protein (PTHrP)....
Background: Surgical management of ankle fractures will be an increasing part the orthopaedic practice for aging adults. To date, there are few studies comparing outcomes after fracture surgery between patients over and under 65 years. The purpose this study was to evaluate short- long-term surgical treatment isolated malleolar in both elderly non-elderly population. Materials Methods: Charts radiographs were reviewed 25 age 46 who underwent operative during a 2-year period. Postoperative...
Abstract Genetic studies have identified a high bone mass of phenotype in both human and mouse when canonical Wnt signaling is increased. Secreted frizzled related protein 1 (sFRP1) one several antagonists among the loss‐of‐function models which 32‐week‐old mice exhibit phenotype. Here we show that impact fracture healing enhanced this model increased at physiologic level young (8 weeks) sFRP1 −/− do not yet significant increases BMD. In vivo deletion function improves repair by promoting...
Purpose: The purpose of this study is to examine the effect establishing a dedicated operating room for unscheduled orthopedic cases and evaluate group patients with isolated femur fractures. frequency after-hours surgery impact who present acute injuries are reviewed. Methods: A retrospective review all from scheduling system at level-one trauma center was undertaken October 2003 September 2005. Before 2004, were placed on shared add-on list, no special priority given cases. Additionally,...
Abstract Vorinostat, an oral histone deacetylase inhibitor with antitumor activity, is in clinical trials for hematologic and solid tumors that metastasize compromise bone structure. Consequently, there a requirement to establish the effects of vorinostat on tumor growth within bone. Breast (MDA-231) prostate (PC3) cancer cells were injected into tibias SCID/NCr mice osteolytic disease assessed by radiography, micro-computed tomography, histologic molecular analyses. Vorinostat-treated...
Extremity fractures are common, and most managed operatively; however, despite successful reduction, up to half of patients report persistent post-surgical pain. Furthermore, psychological factors such as stress, distress, anxiety, depression, catastrophizing, fear-avoidance behaviors have been associated with the development chronic The purpose this pilot study was examine feasibility a randomized controlled trial determine effect in-person cognitive behavioral therapy (CBT) vs. usual care...
Inflammatory mediators and drugs which affect inflammation can influence the healing of injured tissues. Leukotrienes are potent inflammatory mediators, similar to prostaglandins, metabolites arachidonic acid have positive or negative effects on bone cartilage Here we tested hypothesis that blocking regulation leukotrienes, would lead enhanced endochondral formation during fracture repair. A closed femoral was created in mice. Animals were divided into three groups for treatment with either...
Abstract Transcutaneous osseointegration for amputees (TOFA) is an evolving technology that has the potential to revolutionize interface between amputee and their prosthesis, showing at many levels of amputation. While no amputation without its challenges, TOFA requires a highly specialized prosthesis multidisciplinary team includes surgeons, physical therapists, wound care teams, social workers who guide through surgery, postoperative rehabilitation, chronic goes into maintaining...
Outcomes following surgery to operatively manage extremity fractures are variable, and up two-thirds of patients report chronic post-surgical pain. Preliminary evidence suggests that psychotherapy directed at improving coping skills reducing somatic vigilance may improve outcomes among fracture patients. The objective this pilot study was test the feasibility acceptability a randomized controlled trial comparing an online cognitive behavioural therapy (CBT) program versus usual care in with...
Abstract Orthopaedic infections remain challenging complications to treat, with profound economic impact in addition patient morbidity. The overall rate of infection following orthopaedic surgery internal fixation devices has been estimated at 5%, hospital costs 8 times that those without fracture-related and significantly poorer outcomes regarding function pain. Fracture-related (FRIs) occur approximately 20% all trauma cases, treatment evolved very little over the years. While union can be...
OBJECTIVES: To determine the utility of sonication compared to traditional tissue culture in setting fracture-related infections (FRIs). METHODS: Design : Retrospective cohort. Setting: One Level 1 Trauma Center. Patient Selection Criteria: Patients with prior fracture fixation that required a reoperation for suspected infection, nonunion, or hardware failure available data between 2018 and 2023 were included. Outcome Measures Comparisons: The primary outcome was positivity culture. FRI...
Runx2, a master regulator of osteogenesis, is abnormally expressed in advanced prostate cancer. Here, we addressed Runx2 contribution to formation cancer-related osteolytic and osteoblastic bone lesions by mediating TGFβ/BMP signaling through direct interaction with Smads. Further, examined involvement the Runx2-Smad complex tumor growth distal metastasis. To identify Runx2-Smad-specific mechanisms activity bone, generated PC3 cancer cell lines expressing Runx2-WT or one two mutant proteins...
Fasciotomy is the standard of care to treat acute compartment syndrome (ACS). Although fasciotomies often prevent serious complications, postoperative complications can be notable. Surgical site infection (SSI) in these patients as high 30%. The objective this study was determine factors that increase risk SSI with ACS.A retrospective review 142 over 10 years done. We collected basic demographics, mechanism trauma, time fasciotomy, incidence SSI, use prophylactic antibiotics, and type wound...
The incidence of periprosthetic femur fracture in the setting total hip arthroplasty is steadily increasing. Although traditional dogma that loose femoral components must be revised, we propose a frail geriatric population, anatomic reduction and fixation Vancouver B2 B3 variants can restore stem stability provide similar outcomes as revision arthroplasty.Retrospective cohort study.Level 1 trauma center, tertiary academic medical center.We identified 94 patients over 65 years age with...
We present a computational model that integrates mechanobiological regulations, angiogenesis simulations and models natural callus development to simulate bone fracture healing in rodents. The inputs include atomic force microscopy values micro-computed tomography on the first-day post osteotomy, which, combined with detailed finite element modeling, enables scrutinizing mechanical biological interactions early throughout process. mesenchymal stem cell migration patterns, which are essential...