A5088451728- Glycogen Storage Diseases and Myoclonus
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Genetic Neurodegenerative Diseases
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Pericarditis and Cardiac Tamponade
- Sarcoidosis and Beryllium Toxicity Research
- Surgical Sutures and Adhesives
- Potassium and Related Disorders
- Erythrocyte Function and Pathophysiology
- Bipolar Disorder and Treatment
- Cardiac pacing and defibrillation studies
- Hormonal Regulation and Hypertension
- Inflammatory Myopathies and Dermatomyositis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Advanced NMR Techniques and Applications
University of Tübingen
1990-2025
University College London
2019
Thrombosis Research Institute
2019
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Düsseldorf University Hospital
2006
Heinrich Heine University Düsseldorf
2006
Roche (Switzerland)
2003
Heidelberg University
1996
The purpose of this study was to investigate the diagnostic value simultaneous hybrid cardiac magnetic resonance (CMR) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for detection differentiation active (aCS) from chronic (cCS) sarcoidosis. Late gadolinium enhancement (LGE) CMR FDG-PET are both established imaging techniques CS. However, there limited data regarding a comprehensive CMR/FDG-PET approach that includes mapping techniques. Forty-three patients with...
Abstract Aims Heart failure (HF) patients may lack improvement of left ventricular (LV) ejection fraction (LVEF) despite optimal HF medication comprising an angiotensin receptor–neprilysin inhibitor (ARNI). Therefore, we aimed to identify key predictors for LV functional enhancement and prognostic reverse cardiac remodelling in on ARNI treatment. Methods We retrospectively analysed 294 consecutive with reduced (HFrEF) or mildly (HFmrEF) our ‘EnTruth’ patient registry. LVEF was determined by...
Cardiac hypertrophy is characterized by remodeling of the myocardium, which involves alterations in ECM (extracellular matrix) and cardiomyocyte structure. These critically contribute to impaired contractility relaxation, ultimately leading heart failure. Emerging evidence implicates that extracellular signaling molecules are involved pathogenesis cardiac remodeling. The immunophilin CyPA (cyclophilin A) has been identified as a potential culprit. In this study, we aimed unravel interplay...
Nongenomic in vitro effects of aldosterone on the sodium-proton antiport and intracellular second messengers have been described human mononuclear leukocytes, vascular smooth muscle cells, endothelial cells. To test potential physiological relevance these effects, an vivo 31P magnetic resonance spectroscopy study calf at rest during exercise was performed 10 healthy volunteers receiving either 1 mg or placebo iv a double blind, randomized, cross-over trial. Spectra were analyzed for...
Platelet activation plays a critical role in thrombosis and hemostasis. Several pathophysiological situations lead to hemolysis, resulting the liberation of free ferric iron-containing hemin. Hemin has been shown activate platelets induce thrombo-inflammation. Classical antiplatelet therapy failed prevent hemin-induced platelet activation. Thus, aim present study was characterize mechanism death (ferroptosis). We evaluated vitro effect hemin on activation, signaling, oxylipins, plasma...
(1) Background: Compared to acute myocarditis in the initial phase, detection of subacute with cardiac magnetic resonance (CMR) parameters can be challenging due a lower degree myocardial inflammation compared phase. (2) Objectives: To systematically evaluate non-invasive CMR imaging and myocarditis. (3) Methods: 48 patients (age 37 (IQR 28–55) years; 52% female) clinically suspected were consecutively included. Patients onset symptoms ≤2 weeks prior 1.5T assigned group (n = 25, 52%),...
(1) Objectives: To discriminate biopsy-proven myocarditis (chronic vs. healed myocarditis) and to differentiate from dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR). (2) Methods: A total of 259 consecutive patients (age 51 ± 15 years; 28% female) who underwent both endomyocardial biopsy (EMB) CMR in the years 2008–2021 were evaluated. According right-ventricular EMB results, divided into either chronic (n = 130, 50%) or lymphocytic 60, 23%) DCM 69, 27%). The protocol...
Increased high-sensitive cardiac troponin I (hs-cTnI) levels are common in patients with acute ischemic stroke. However, only a minority demonstrates culprit lesions on coronary angiography, suggesting other mechanisms, e.g., inflammation, as underlying cause of myocardial damage. Late Gadolinium Enhancement (LGE)-cardiac magnetic resonance (CMR) mapping techniques [T1, T2, extracellular volume (ECV)] allow the detection both focal and diffuse abnormalities. We investigated prevalence by...
Zielsetzung Um fortgeschrittene Stadien abgelaufener Myokarditis mit dilatativer Kardiomyopathie (DCM) anderer Ursache zu vergleichen.