A5029961655- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Structural Anomalies and Repair
- Chronic Kidney Disease and Diabetes
- Cardiac Fibrosis and Remodeling
- Parathyroid Disorders and Treatments
- Electrolyte and hormonal disorders
- Diabetes and associated disorders
- Pharmacology and Obesity Treatment
- Heart Failure Treatment and Management
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Management and Research
- Sepsis Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Pancreatitis Pathology and Treatment
- Diet and metabolism studies
- Immune cells in cancer
- Cardiovascular Function and Risk Factors
- Signaling Pathways in Disease
- Cholesterol and Lipid Metabolism
- Phosphodiesterase function and regulation
- Inflammation biomarkers and pathways
- 3D Printing in Biomedical Research
RWTH Aachen University
2013-2025
Universitätsklinikum Aachen
2014-2025
St. Elizabeth Healthcare
2024
Deutsches Herzzentrum der Charité
2013
Hypoglycemia and hyperglycemia are both predictors for adverse outcome in critically ill patients. Hyperinsulinemia is induced by inflammatory stimuli as a relevant mechanism glucose lowering the ill. The incretine hormone GLP-1 was currently found to be endotoxin, leading insulin secretion under conditions mice. Here, we describe increased variety of stimuli, including interleukin-1β (IL-1β), IL-6. Although abrogation IL-1 signaling proved insufficient prevent endotoxin-dependent induction,...
Background: Cardiovascular diseases and chronic kidney disease (CKD) are highly prevalent, aggravate each other, account for substantial mortality. Both conditions characterized by activation of the innate immune system. The alarmin interleukin-1α (IL-1α) is expressed in a variety cell types promoting (sterile) systemic inflammation. aim present study was to examine role IL-1α mediating inflammation setting acute myocardial infarction (AMI) CKD. Methods: We assessed expression on surface...
Abstract Background In the EMPA-REG OUTCOME trial (Empagliflozin Cardiovascular Outcome Event Trial) treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitor empagliflozin significantly reduced heart failure hospitalization (HHF) in patients type 2 diabetes mellitus (T2D) and established cardiovascular disease. The early separation of HHF event curves within first 3 months suggest that immediate hemodynamic effects may play a role. However, hitherto no data exist on SGLT2 inhibitors...
Myocardial infarction (MI) is a major cause of death in Western countries and finding new strategies for its prevention treatment thus high priority. In previous study, we have demonstrated pathophysiologic relevance the heterophilic interaction CCL5 CXCL4 progression atherosclerosis. A specifically designed compound (MKEY) to block this CCL5-CXCR4 investigated as potential therapeutic model myocardial ischemia/reperfusion (I/R) damage. 8 week-old male C57BL/6 mice were intravenously treated...
Abstract Sodium‐glucose cotransporter‐2 ( SGLT2 ) inhibitors have been shown to significantly reduce hospitalization for heart failure HHF and cardiovascular CV mortality in various outcome trials patients with without type 2 diabetes mellitus T2D ). inhibition further increased haemoglobin haematocrit levels by an as yet unknown mechanism, this increase has be independent predictor of the benefit these agents, example, EMPA‐REG OUTCOME trial. The present analysis EMPA haemodynamic study...
Abstract Aims In this prospective, placebo‐controlled, double‐blind, exploratory study, we examined early and more delayed effects of empagliflozin treatment on haemodynamic parameters (primary endpoint: cardiac output) kidney function including acute injury (AKI) in patients with decompensated heart failure (HF). Methods results Patients HF or without diabetes were randomized to 10 mg placebo for 30 days. Haemodynamic, laboratory, urinary assessed after 6 h, 1 day, 3 days, 7 days treatment....
Background Although macrophage migration inhibitory factor ( MIF ) has been demonstrated to mediate cardioprotection in ischemia/reperfusion injury and antagonize fibrotic effects through its receptor, CD 74, the function of soluble 74 receptor ectodomain sCD 74) interaction with circulating have not explored cardiac disease. Methods Results Cardiac fibroblasts were isolated from hearts neonatal mice differentiated into myofibroblasts. Co-treatment recombinant induced cell death P<0.001),...
The incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by the gut after food intake leading to pancreatic insulin secretion glucose lowering. Beyond its role in control, was found mice men beneficially modulate process of atherosclerosis, which has been linked improved cardiovascular outcome patients with diabetes at high risk treated receptor agonists. However, little is known on other main system. aim this study characterize...
Abstract Neonatal sepsis is characterized by hyperinflammation causing enhanced morbidity and mortality compared to adults. This suggests differences in the response towards invading threats. Here we investigate activated cord blood macrophages (CBMΦ) comparison adult (PBMΦ), indicating incomplete interferon gamma (IFN-γ) interleukin 10 (IL-10)-induced activation of CBMΦ. CBMΦ show reduced expression phagocytosis receptors cytokine addition altered energy metabolism. In particular, IFN-γ as...
A high-fat diet increases bacterial lipopolysaccharide (LPS) in the circulation and thereby stimulates glucagon-like peptide 1 (GLP-1)–mediated insulin secretion by upregulating interleukin-6 (IL-6). Although microRNA-155-5p (miR-155-5p), which IL-6 expression, is upregulated LPS hyperlipidemia patients with familial hypercholesterolemia less frequently develop diabetes, role of miR-155-5p islet stress response to unclear. In this study, we demonstrate that hyperlipidemia-associated...
Arising in inflammatory conditions, myeloid-derived suppressor cells (MDSCs) are constantly confronted with intracellular and extracellular reactive oxygen species molecules oxidative stress. Generating mice a constitutive activation of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) we show pivotal role the antioxidant stress defense for development these immune-modulatory cells. These characterized by massive increase splenic CD11b+Gr-1+ cells, which exhibit typical suppressive...
Abstract Atherosclerosis is a chronic inflammatory disease characterized by the infiltration of pro-inflammatory macrophages into lipid-laden plaque. ITCH an E3 ubiquitin ligase that has been shown to polarize anti-inflammatory phenotype. We therefore investigated effect deficiency on development atherosclerosis. ApoE−/−ITCH−/− mice fed western diet for 12 weeks showed increased circulating M2 together with reduction in plaque formation. Bone marrow transplantation recreated haemopoietic...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, glucose-lowering drugs that increase urinary glucose excretion have been shown to reduce CV events in patients with type 2 diabetes (T2D). Furthermore, several studies demonstrated treatment SGLT2 inhibitors affect calcium and phosphate homeostasis, but the effect of empagliflozin on these biomarkers is hitherto not investigated detail. Therefore, this analysis EMPA hemodynamics study examined effects homeostasis.In placebo-controlled,...
Aims To investigate the metabolic effects of phosphodiesterase‐4 (PDE4) inhibitor roflumilast, a clinically approved anti‐inflammatory drug used for treatment chronic obstructive pulmonary disease. Materials and methods The roflumilast were investigated in C57BL/6J mice, fed high‐fat Western‐type diet treated with or without period 12 weeks. Results Roflumilast led to marked reduction body weight gain, which became apparent second week after initiation was attributable pronounced increase...
Coexistent CKD and cardiovascular diseases are highly prevalent in Western populations account for substantial mortality. We recently found that apolipoprotein C-3 (ApoC3), a major constituent of triglyceride-rich lipoproteins, induces sterile systemic inflammation by activating the NOD-like receptor protein-3 (NLRP3) inflammasome human monocytes via an alternative pathway.
ABSTRACT Patients with chronic kidney disease are at an increased risk of developing heart failure, but the underlying mechanisms remain incompletely understood, least in part because paucity mouse models uremic cardiomyopathy. In this study, we used two different experimental setups 2,8‐dihydroxyadenine‐induced nephropathy strains to develop a non‐invasive model Among models, only 129/Sv mice fed adenine‐supplemented diet for 16 weeks showed typical features Kidney damage was confirmed by...
Recently, glucagon-like peptide-1 (GLP-1) levels have been found to be increased in response inflammatory stimuli, leading insulin secretion and prevention of hyperglycaemia during endotoxemia mice. In the present study, we assess relevance other incretin hormone, glucose-dependent insulinotropic peptide (GIP), as a regulator glucose metabolism under conditions. We that lipopolysaccharide (LPS) GIP time- dose-dependent manner C57BL/6J To elucidate underlying mechanisms, mice were injected...
Cardiac hypertrophy is characterized by remodeling of the myocardium, which involves alterations in ECM (extracellular matrix) and cardiomyocyte structure. These critically contribute to impaired contractility relaxation, ultimately leading heart failure. Emerging evidence implicates that extracellular signaling molecules are involved pathogenesis cardiac remodeling. The immunophilin CyPA (cyclophilin A) has been identified as a potential culprit. In this study, we aimed unravel interplay...
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MΦ differentiate from circulating monocytes (Mo). The reduced ability of neonatal Mo to undergo apoptosis after E. coli infection (phagocytosis-induced cell death (PICD)) could contribute sustained inflammatory processes. objective our study was investigate whether immune metabolism in can be modified gain access pro-apoptotic signaling. To this end, we supplemented neonates and adults with the branched amino acid leucine. In Mo, observed increased energy production via oxidative...
Objectives: Patients with cardiogenic shock undergoing coronary artery bypass grafting (CABG) surgery are recommended to be supported by intraaortic balloon counter pulsation (IABP) therapy. The optimal beginning of the IABP therapy, before or after surgical revascularization, remains questionable.