A5030577718- Pharmacological Effects of Natural Compounds
- Thin-Film Transistor Technologies
- Orthopaedic implants and arthroplasty
- Hepatitis B Virus Studies
- Medicinal Plants and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Hydrogels: synthesis, properties, applications
- Ocular Diseases and Behçet’s Syndrome
- Hip disorders and treatments
- Ginseng Biological Effects and Applications
- Silicon and Solar Cell Technologies
- Drug Solubulity and Delivery Systems
- Graphite, nuclear technology, radiation studies
- Ecology and Conservation Studies
- Skin Protection and Aging
- Total Knee Arthroplasty Outcomes
- Pharmacy and Medical Practices
- melanin and skin pigmentation
- Advanced Polymer Synthesis and Characterization
- Food Quality and Safety Studies
- Orthopedic Infections and Treatments
- Membrane Separation and Gas Transport
- Silk-based biomaterials and applications
- Semiconductor materials and interfaces
- Religion, Ecology, and Ethics
Konyang University
2013-2024
Korea National University of Transportation
2018-2023
Next Generation Technology (United States)
2023
Sogang University
2020
Daegu Fatima Hospital
2002-2016
Korea Institute of Science and Technology
2013-2014
Pusan National University
2011
Jeonbuk National University
2006-2008
Korea Research Institute of Chemical Technology
2005-2007
Samsung (South Korea)
2004-2007
Abstract MPEG–PCL diblock copolymers consisting of methoxy polyethylene glycol (MPEG, 750 g/mol) and poly(ϵ‐caprolactone) (PCL) were synthesized by ring‐opening polymerization. Aqueous solutions the prepared dissolving at concentrations in range 0–20 wt %. When PCL molecular weight was 3000 or greater, polymer only partially soluble water. As temperature increased from room temperature, copolymer showed two phase transitions: a sol‐to‐gel transition gel‐to‐sol transition. The decreased...
Abstract Under endoplasmic reticulum ( ER )‐stress conditions, the unfolded protein response UPR ) generates a defense mechanism in mammalian cells. The regulation of signaling is important oocyte maturation, embryo development, and female reproduction pigs. Recent studies have shown that melatonin plays an role as antioxidant to improve pig maturation. However, there no report on ‐stress during vitro maturation IVM porcine oocytes. Therefore, objective this study was investigate...
An appropriate cellular response to implanted surfaces is essential for tissue regeneration and integration. In this study, we investigated how human bone marrow stromal cells (hBMSCs) respond scaffold substrates. We prepared wettable polymer by exposing sheets radio frequency plasma discharge, which gradually oxidizes the surface, increasing roughness greatly reducing hydrophobicity. found that hBMSCs adhered better highly hydrophilic rough than hydrophobic smooth surfaces. addition,...
Raloxifene hydrochloride (RLH) was formulated into a pH-modified supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) to increase solubility and dissolution rate. Optimal formulations of S-SMEDDSs were developed by incorporating hydroxypropyl-cellulose-L as precipitation inhibitor phosphoric acid pH modifier (an acidifier). RLH dissolved greater extents all compared with non-pH-modified S-SMEDDSs. In particular, afforded than did the other acidifiers tested, perhaps because...
Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB prepared by changing the drug:polymer ratio (Polyvinylpyrrolidione-vinyl acetate 64, 1:1–1:4) and barrel temperature (200–240 °C), fixed at 20% of Cremophor® RH 40 15 rpm screw speed, using extruding technique. This study evaluates...
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by cognitive deficits, which are accompanied memory loss and disruption. Rhodiola sachalinensis (RSE) a medicinal plant that has been used in northeastern Asia for various pharmacological activities. We attempted to carry out the bioconversion of RSE (Bio-RSE) using mycelium Bovista plumbe obtain tyrosol-enriched Bio-RSE. The objective this study was investigate effects Bio-RSE on activation cholinergic...
Atherosclerosis is one of the most reported diseases worldwide, and extensive research trials are focused on discovery utilizing for novel therapeutics. Nitric oxide (NO) produced mainly by endothelial nitric synthase (eNOS) it plays a key role in regulating vascular function including systemic blood pressure inflammation endothelium. In this study hypothesized that Impressic acid (IPA), component isolated from Acanthopanax koreanum, acts as an enhancer eNOS activity NO production. IPA...
본 연구에서는 병꽃나무 꽃 추출물의 항산화 효과 및 LPS로 자극된 RAW 264.7 대식세포에서 항염증 효과를 조사하였다. 총 폴리페놀과 플라보노이드 함량을 측정한 결과 폴리페놀 함량과 플라보노이 함량은 각각 719.19±0.04 μg/ml, 644.87±0.02 μg/ml로 나타났다. 활성을 확인하기 위하여 DPPH 라디칼과 superoxide 음이온 라디칼 소거 투여 농도 의존적으로 활성이 증가하는 것으로 또한 염증 매개물질인 NO와 inflammatory cytokine인 IL-6와 TNF-α의 생성량을 측정하였다. 그 IL-6의 생성을 투여농도 저해하였지만, 경우 농도가 20 μg/ml 이하에서는 억제하지 않았고 100 이상에서는 오히려 분비를 유도하는 또한, 염증반응과 관련된 iNOS 발현과 MAPK NF-κB의 활성에 미치는 영향을 iNOS는 유의적으로 발현이 감소되었으며, MAPK의 발현 인산화에는 별다른 미치지 못하는 반면에 IκB의 인산화를 효과적으로...
Black rice bran extract (BRBE), containing various biologically active compounds, such as anthocyanin, has antioxidant activity and numerous pharmacological effects. Here, we aimed to confirm the immunostimulatory effects of BRBE in cyclophosphamide (CP)-induced immunosuppressed cells. Our results confirmed that exerted an effect. In vitro, treatment enhanced cell proliferation, natural killer cells cytotoxic T lymphocytes, production CP-repressed cytokines, tumor necrosis factor-α,...
Abductor deficiency in native hip joint may cause severe limping and pain. It is more serious situation case of arthroplasty due to instability recurrent dislocation. Well-known causes abductor are repeated surgery, chronic trochanteric bursitis, superior gluteal nerve injury, failure repair tendon insertion the greater trochanter. Author had experienced primary during total replacement treated successfully with transfer gluteus maximus. We'd like introduce operation technique review literature.
Differential interference contrast microscopy is designed to image unstained and transparent specimens by enhancing the resulting from Nomarski prism-effected optical path difference. Retinitis pigmentosa, one of most common inherited retinal diseases, characterized progressive loss photoreceptors. In this study, was evaluated as a new simple application for observation photoreceptor layer retinitis pigmentosa diagnostics monitoring. Retinal tissues Royal College Surgeons rats...
Who defends democracy? This is a question central to the literature on democratic development, and new generation of scholars has integrated structural- actor-centric approaches democratization produce generalizable insights. However, their theoretical arguments lack sufficient empirical evidence from non-Western countries. From late October 2016 April 2017, seven million Koreans (14% population) raised candles participated in anti-government rallies, which eventually halted deconsolidation...
Ponciri fructus, the unripe fruits of Poncirus trifoliata, are widely used in oriental traditional medicine as a remedy for inflammation, gastritis, emesis, digestive ulcers, allergy, and dysentery. To study anti-wrinkle effects fructus extract (PFE) containing flavanone glycosides, PFE was fermented with Ganoderma lucidum mycelia its biological activities were investigated. In extracts G. (G-PFE), polyphenol content <TEX>$1,021.00{\pm}0.50{\mu}g/mL$</TEX> flavonoid...
Pig-human xenotransplantation can trigger cell-mediated immune responses. We explored the role of gangliosides in inflammation related to rejection xenotransplantation. Co-culture xenogeneic cells (pig-MSCs and RAW264.7) was used emulate conditions. MTT assay results indicated that cell viability significantly decreased pADMSCs co-cultured with RAW264.7 cells. GM1 GM3 were highly expressed strongly pro-inflammatory proteins such as COX-2, iNOS, p50, p65, pIκBα, TNF-α. GM1-knockdown RAW 264.7...
The effect of Rhodiola sachalinensis Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection 20 mg/kg testosterone propionate (TP) to induce BPH. Then, the only group testosterone, + finasteride and (5 mg/kg), HKC (500 mg/kg). Prostate weight dihydrotestosterone (DHT) levels in serum or prostate tissue were determined. mRNA expressions 5-alpha reductase (AR) also measured....