A5037572757- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Fluorine in Organic Chemistry
- Microbial bioremediation and biosurfactants
- Microbial Metabolic Engineering and Bioproduction
- Microplastics and Plastic Pollution
- Catalytic Cross-Coupling Reactions
- biodegradable polymer synthesis and properties
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Acute Kidney Injury Research
- Mitochondrial Function and Pathology
- Renal and Vascular Pathologies
- Adrenal Hormones and Disorders
- Genomics and Phylogenetic Studies
- Advanced Proteomics Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Organophosphorus compounds synthesis
University Hospital Carl Gustav Carus
2020-2021
Technische Universität Dresden
2020-2021
Medical University of Graz
2015-2016
University of Graz
2016
Austrian Centre of Industrial Biotechnology (Austria)
2015
BioTechMed-Graz
2015
University of Bergen
2015
A novel esterase, PpEst, that hydrolyses the co-aromatic-aliphatic polyester poly(1,4-butylene adipate-co-terephthalate) (PBAT) was identified by proteomic screening of Pseudomonas pseudoalcaligenes secretome. PpEst induced presence PBAT in growth media and had predicted arylesterase (EC 3.1.1.2) activity. showed polyesterase activity on both whole milled film releasing terephthalic acid 4-(4-hydroxybutoxycarbonyl)benzoic while end product inhibition observed. Modelling an aromatic mimicking...
Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours with a hereditary background in over one-third of patients. Mutations succinate dehydrogenase (SDH) genes increase the risk for PPGLs several other tumours. subunit B (SDHB) particular factor metastatic disease, further highlighting importance identifying SDHx mutations patient management. Genetic variants unknown significance, where implications family members unclear, problem interpretation. For such cases,...
The adrenal gland is important for many physiological and pathophysiological processes, but studies are often restricted by limited availability of sample material. Improved methods preparation needed to facilitate analyses multiple classes metabolites macromolecules in a single sample. A procedure was developed chromaffin cells, mouse adrenals, human tumors that allows multi-omics different preservation native proteins. To evaluate the new procedure, aliquots samples were also prepared...
Within the past decade, important genetic drivers of pheochromocytoma and paraganglioma (PPGLs) development have been identified. The pathophysiological mechanism that translates these alterations into functional autonomy potentially malignant behavior has not elucidated in detail. Here we used MALDI-mass spectrometry imaging (MALDI-MSI) formalin-fixed paraffin-embedded tissue specimens to comprehensively characterize metabolic profiles PPGLs.MALDI-MSI was conducted 344 PPGLs results...
A better understanding of the inflammatory process associated with renal ischaemia-reperfusion (IR) injury may be clinically important. In this study we examined role kidney in production mediators by analysing lymph after 30 min unilateral occlusion artery followed 120 reperfusion, as well effect IR on size selectivity for proteins both glomerular and peritubular capillaries. All measured increased dramatically hilar lymph, plasma cortical tissue samples returned to control levels...
Mitotane is the only drug approved for therapy of adrenocortical carcinoma (ACC). Its clinical use limited by occurrence relapse during therapy. To investigate underlying mechanisms in vitro , we here generated mitotane-resistant cell lines. After long-term pulsed treatment HAC-15 human cells with 70 µM mitotane, isolated monoclonal populations treated and controls assessed their respective mitotane sensitivities MTT assay. We performed exome sequencing electron microscopy, conducted gene...
A sequence is developed for the conversion of arylphosphonic acids into arylfluorophosphonates through selective monoesterification and subsequent fluorination.