A5020094733- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Orthopedic Infections and Treatments
- Fungal Infections and Studies
- Diagnosis and treatment of tuberculosis
- Cancer therapeutics and mechanisms
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Vectors
- Diversity and Career in Medicine
- Veterinary medicine and infectious diseases
- Actinomycetales infections and treatment
- Dermatologic Treatments and Research
- Nail Diseases and Treatments
- Tendon Structure and Treatment
- Malaria Research and Control
- Genetic and Kidney Cyst Diseases
- Healthcare professionals’ stress and burnout
- Foot and Ankle Surgery
- Streptococcal Infections and Treatments
- COVID-19 Impact on Reproduction
- Otolaryngology and Infectious Diseases
- melanin and skin pigmentation
- Bacterial Identification and Susceptibility Testing
Allegheny General Hospital
2021-2024
Allegheny Health Network
2021-2023
Johns Hopkins Medicine
2016-2019
Johns Hopkins University
2016-2019
MedStar Health
2019
Maulana Azad Medical College
2014
Govind Ballabh Pant Hospital
2014
The modern patient is increasingly susceptible to bacterial infections including those due multidrug-resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen-specific imaging technologies can significantly improve outcomes by rapidly identifying a source of infection and monitoring the response treatment, but no such technology exists clinically.We systematically screened 961 random radiolabeled molecules in silico as substrates for essential metabolic pathways bacteria,...
The medical treatment of periprosthetic joint infection (PJI) involves prolonged systemic antibiotic courses, often with suboptimal clinical outcomes including increased morbidity and health-care costs. Oral intravenous monotherapies combination regimens were evaluated in a mouse model methicillin-resistant Staphylococcus aureus (MRSA) PJI.Oral linezolid or without oral rifampin, vancomycin daptomycin ceftaroline doxycycline, sham administered at human-exposure doses for 6 weeks PJI....
The antileprosy drug clofazimine was recently repurposed as part of a newly endorsed short-course regimen for multidrug-resistant tuberculosis. It also enables significant treatment shortening when added to the first-line drug-susceptible tuberculosis in mouse model. However, causes dose- and duration-dependent skin discoloration patients, optimal dosing strategy context is unknown. We utilized well-established model systematically address impacts duration, dose, companion drugs on...
The potent antituberculosis activity and long half-life of bedaquiline make it an attractive candidate for use in long-acting/extended-release formulations the treatment latent tuberculosis infection (LTBI). Our objective was to evaluate a long-acting injectable (LAI) formulation validated paucibacillary mouse model LTBI. Following immunization with Mycobacterium bovis rBCG30, BALB/c mice were challenged by aerosol M. H37Rv. Treatment began 13 weeks after challenge one following regimens:...
Mosquito borne diseases (MBDs) are major public health problem in India. State of Delhi is endemic for dengue and other MBDs. The increasing incidence MBDs recent years warrants a pro-active approach their prevention. Knowledge use personal protective measures (PPMs) presents an effective strategy prevention control MBDs.The present study was conducted to assess the knowledge PPMs against urban resettlement colony Delhi.It cross-sectional carried out Delhi. A total 100 families were selected...
Starting in 2004, the standard regimen for treatment of Buruli ulcer (BU) recommended by World Health Organization has been daily eight weeks with rifampin (RIF) and streptomycin. Based on recent clinical trials, an all-oral RIF clarithromycin (CLR) may be effective alternative. With achievement regimen, a new goal is to find that can shorten duration without compromising efficacy. We recently observed increasing dose from 10 mg/kg 20 or 40 mg/kg, replacing more potent long-acting rifamycin,...
Clofazimine and high-dose rifapentine have each separately been associated with treatment-shortening activity when incorporated into tuberculosis (TB) treatment regimens. We hypothesized that both modifications, i.e., the addition of clofazimine replacement rifampin rifapentine, in first-line regimen for drug-susceptible TB would significantly shorten duration necessary cure. tested this hypothesis a well-established BALB/c mouse model chemotherapy also C3HeB/FeJ which mice can develop...
Abstract Background Electronic Health Record (EHR) implementation has created an unprecedented library of patient data. Data extraction tools provide opportunity to retrieve clinico-epidemiological information on a wide scale. Slicer Dicer is data exploration tool in the EPIC EHR that allows one customize searches large populations. This software contains variety models present de-identified from EPIC’s Caboodle database. We explored applicability and potential utility this utilizing...
Matrix metalloproteinase (MMP)-9 is a zinc-dependent protease associated with early immune responses to Mycobacterium tuberculosis infection, macrophage recruitment and granuloma formation. We evaluated whether adjunctive inhibition of MMP-9 could improve the response standard TB treatment in mouse model that develops necrotic lesions. Six weeks after an aerosol infection M. tuberculosis, C3HeB/FeJ mice received (12 weeks) comprising rifampin, isoniazid pyrazinamide alone or combination...
Limited descriptive data exist regarding the clinical characteristics of hospitalizations due to severe acute respiratory syndrome coronavirus 2 Omicron variant based on vaccination status.This was a retrospective cohort study all patients hospitalized with diagnosis disease 2019 (COVID-19) between 15 January 2022 and February across 9 hospitals in large health network. Data were extracted by manual records review.A total 351 452 (77.7%) unvaccinated, 209 331 (63.1%) fully vaccinated, 107...
Scedosporiosis is an opportunistic mycosis that may cause disseminated disease in transplant recipients. This article reports a case of recurrent Scedosporium apiospermum mediastinitis without pneumonia orthotopic heart recipient, with durable control achieved by long-term antifungal therapy and serial debridement. highlights the importance scedosporium infection immunocompromised hosts, given challenges microbiological identification limited treatment options.
Lemierre's syndrome (LS) is a potentially fatal complication of oropharyngeal infection, resulting in contiguous suppurative thrombosis the internal jugular vein (IJV) and septic emboli. It most commonly associated with Fusobacterium necrophorum (F. necrophorum), though other pathogens have also been implicated its pathogenesis. The incidence LS had so significantly decreased that it was referred to as "the forgotten disease." However, cases shown resurgence, which may be partly attributed...
Immunocompromised patients, especially organ transplant recipients, are at risk for opportunistic infections. Cryptococcus, a ubiquitous environmental fungus, can cause potentially fatal infection in such hosts. While it involve any the human body, respiratory and central nervous systems commonly affected. We present case of disseminated cryptococcal liver recipient whom initial presentation was bilateral axillary lymphadenopathy, relatively rare clinical manifestation. Rapid diagnosis...
Direct specimen sequencing (DSS) offers the promise of enhanced pathogen detection and disease diagnosis.A single healthcare network, retrospective chart review over a 3-year period was completed for all cases in which DSS submitted, addition to conventional testing (CT) workup an infectious disease. We sought compare results (concordance discordance) from these 2 techniques order evaluate any additional yield CT. Additionally, we calculated mean turnaround time (TAT) average cost obtaining...
Despite the increasing number of women within medical professions, gender equality in career advancement and leadership positions still remains a challenge due to numerous barriers including unbalanced domestic responsibilities, discrimination, rigidity structures. Here, we discuss ways achieve work-life balance family planning as well some challenges face medicine nursing careers outline strategies for individuals organizations overcome them.
ABSTRACT The potent anti-tuberculosis activity and long half-life of bedaquiline make it an attractive candidate for long-acting/extended release formulations treatment latent tuberculosis infection (LTBI). Our objective was to evaluate a long-acting injectable (LAI) formulation in validated paucibacillary mouse model LTBI. Following immunization with Mycobacterium bovis rBCG30, BALB/c mice were challenged by aerosol M. H37Rv. Treatment began 13 weeks after challenge one the following...
ABSTRACT High-dose rifapentine and clofazimine have each separately been associated with treatment-shortening activity when incorporated into tuberculosis (TB) treatment regimens. We hypothesized that both modifications, i.e., the addition of replacement rifampin high-dose rifapentine, in first-line regimen for drug-susceptible TB would significantly shorten duration necessary cure. tested this hypothesis a well-established BALB/c mouse model chemotherapy also C3HeB/FeJ which mice can...
Abstract Background Pseudomonas fluorescens is a water-borne pathogen that has been associated with outbreaks from transfusion of contaminated blood products or medical equipment. Our institution had cluster cultures grew an uncommonly encountered microbe P. within period one week. This prompted internal investigation. We summarize the investigational process led to resolution this pseudo-outbreak. Methods conducted retrospective chart review surgical and non-surgical patients positive for...
Abstract Background Clinical microbiology traditionally relies on culture methodology and serological testing, that have inherent limitations. Newer diagnostic techniques such as Next Generation Sequencing (NGS) shown promise to improve microbial identification. In select scenarios, we send clinical specimens reference laboratories for NGS testing in addition current standard of care (SOC) diagnostics. We wanted determine how this approach has impacted patient care. also review the financial...