A5079242825- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Lysosomal Storage Disorders Research
- Pancreatic function and diabetes
- Cellular transport and secretion
- Air Quality and Health Impacts
- Viral Infections and Outbreaks Research
- Urban Transport and Accessibility
- Virus-based gene therapy research
- Nonmelanoma Skin Cancer Studies
- vaccines and immunoinformatics approaches
- Glycosylation and Glycoproteins Research
- Biochemical Acid Research Studies
- Global Health and Surgery
- Genetic and Kidney Cyst Diseases
- Aging and Gerontology Research
- Coenzyme Q10 studies and effects
- Dental Radiography and Imaging
- SARS-CoV-2 and COVID-19 Research
- Cutaneous Melanoma Detection and Management
- PI3K/AKT/mTOR signaling in cancer
- Endodontics and Root Canal Treatments
- Viral gastroenteritis research and epidemiology
- Vitamin D Research Studies
Sun Yat-sen University
2017-2025
First Affiliated Hospital of Wannan Medical College
2021-2023
Wannan Medical College
2021-2023
Chuzhou University
2020
China Pharmaceutical University
2016-2018
Shanghai Posts & Telecommunications Designing Consulting Institute
2018
Chengde Medical University
2017
State Key Laboratory of Natural Medicine
2016
University of Hong Kong
2008
McGill University
2005-2008
As a gene associated with anemia, the erythropoiesis is physiologically expressed under hypoxia regulated by †hypoxia-inducing factor-α (HIF-α). Thus, stabilizing HIF-α potent strategy to stimulate expression and secretion of erythropoiesis. In this study, we applied click chemistry discovery HIF prolyl hydroxylase 2 (HIF-PHD2) inhibitors for first time, series triazole compounds showed preferable inhibitory activity in fluorescence polarization assays. Of particular note was orally active...
Abstract The regulation and homeostasis of autophagy are essential for maintaining organ morphology function. As a lysosomal membrane protein, the effect Sidt2 on kidney structure renal is still unknown. In this study, we found that kidneys −/− mice showed changes in basement thickening, foot process fusion, mitochondrial swelling, suggesting was damaged. Increased urine protein at 24 h indicated function also At same time, absence caused decrease number acidic lysosomes, acid hydrolase...
Background Precise public health and clinical interventions for the COVID-19 pandemic has spurred a global rush on SARS-CoV-2 variant tracking, but current approaches to tracking are challenged by flood of viral genome sequences leading loss timeliness, accuracy, reliability. Here, we devised new co-mutation network framework, aiming tackle these difficulties in surveillance. Methods To avoid simultaneous input modeling whole large-scale data, dynamically investigate nucleotide covarying...
In this study, we explored the role and mechanisms of Cyclocarya paliurus polysaccharide on cell apoptosis in thyroid cancer (TC) cells. The cells vitro tumor tissues vivo induced by was determined MTT assay flow cytometric assay. downstream molecules including phosphop-protein kinase B (p-Akt), Akt, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) tissue were evaluated western blotting. cytometry revealed polysaccharide-induced line a manner time-dependent dose-dependent. showed...
Isoform expression of CD44 in follicular carcinoma (FC) the thyroid was analyzed by Immunohistochemlcal staining and compared to isoforms In adenoma (FA) papillary (PC) thyroid. Variant (CD44v) were detected these neoplastic cells but not non‐neoplastlc cells. CD44v6 expressed PC with nodal metastasis also FC at significantly higher frequencies than those without FA. The frequency CD44v3 metastasis. reverse transcription‐polymerase chain reaction (RT‐PCR) followed Southern blotting analysis...
Introduction Evidence on the interaction of lifestyle and long-term ambient particle (PM) exposure prevalence hypertension, diabetes, particularly their combined condition is limited. We investigate associations between PM these outcomes whether were modified by various lifestyles. Methods This was a large population-based survey during 2019–2021 in Southern China. The concentrations interpolated assigned to participants residential address. Hypertension diabetes status from questionnaires...
Diabetic nephropathy (DN) is one of the most lethal complications diabetes mellitus with chronic inflammation. We have examined role inflammatory chemokine CCL24 in DN. observed that serum levels were significantly elevated patients Not only that, expression was increased kidneys DN mice. The kidney mice showed renal fibrosis and characterized an vitro podocyte cell model high glucose. Western blot analysis under high-glucose conditions. Stimulation glucose (35 mmol/L) resulted increase...
Background Hand, foot, and mouth disease (HFMD) is a major public health issue in China while temperature humidity are well-documented predictors. However, evidence on the combined effect of still limited. It also remains unclear whether such an could be modified by enterovirus 71 (EV71) vaccination. Methods Based 320,042 reported HFMD cases during summer months between 2012 2019, we conducted study utilizing Distributed Lag Non-Linear Models (DLNM) time-varying DLNM to examine how China’s...
Objective To assess the psychological status of staff at centers for disease control and prevention(CDC) in Sichuan during outbreak coronavirus 2019(COVID-19) explore influencing factors. Methods The provincial,municipal,and county(district)-level CDC were selected by convenience sampling.Their basic information,work status,training status,work difficulties,and support from work group collected self-filled questionnaires online.The Generalized Anxiety Disorder Scale 9-question Patient Health...
Alzheimer's disease (AD) is characterized by β-amyloid (Aβ) overproduction and tau hyperphosphorylation. Familial Alzheimer mutations of presenilin 1 (PS-1) enhance the generation Aβ42 intracellular accumulation. However, effect PS-1 on phosphorylation underlying mechanisms were poorly understood, there no treatment to arrest pathology. Western blot, Immunohistochemistry SOD activity assay performed in this study. Tau at Ser396, Ser404 Tau-1 (Ser198/199/202) epitopes was increased...
Abstract Background Current global health course is most set as elective taught in traditional teacher-taught model with low credit and short term. Innovate teaching models are required. Crowdsourcing characterized by high flexibility strong application-orientation holds its potential to enhance education. We applied crowdsourcing for undergraduates, aiming develop evaluate a new Methods was implemented into course-based via introducing five COVID-19 related debates. Undergraduate students...
Objective To explore the efficacy of salmon calcitonin combined with vitamin D3 in treatment chronic renal insufficiency and secondary hyperthyroidism its effects on bone calcium metabolism. Methods A total 40 patients failure who underwent hemodialysis our blood purification center from September 2017 to December were selected for study divided into group (20 cases) control according random number table method. Patients given conventional + calcitriol orally, subcutaneous injection...
Objective To measure the expression of protein kinase D1 (PKD1) , tyr463-phos-phorylaed PKD1 (pPKD1-tyr463) and ser916-phos-phorylaed (pPKD1-ser916) in squamous cell carcinoma (SCC) Bowen's disease (BD) actinic keratosis (AK) to explore their significance. Methods Fresh tissue samples were resected from lesions patients with SCC (SCC group) BD (BD AK (AK as well normal skin healthy human controls (control each group had a sample size 10. Real-time RT-PCR was performed mRNA gene...
Abstract Background: To fight against COVID-19, many policymakers are wavering on stricter public health interventions. However, relying these measures but different strategies, both in and out of China’s Hubei province basically contained the epidemic late February 2020. This study aimed to assess response process estimate time-varying effect control strategy provide insights for intervention design implementation. Methods: We retrospectively compared spread COVID-19 between (excluding...