Purpose: Autologous serum eye drops are considered to be safe and efficient for the treatment of dry eyes associated with Sjögren syndrome (SS). The purpose this study was compare clinical efficacies autologous in management primary secondary SS. Methods: Patients (n = 20; 35 eyes) 14; 27 SS were included. Serum concentrations proinflammatory cytokines [tumor necrosis factor α, interleukin (IL)-1β, IL-6, IL-8] measured by a multiplex immunobead assay. ocular symptom scores, staining grades,...

The external part of the eye shares mucosa-associated common characteristics and is an obvious entry site for foreign Ags. We assessed potential eyedrop vaccination effective delivery vaccines against viral or bacterial infection in mice. Both OVA-specific IgG Ab serum IgA mucosal compartments were induced by eyedrops OVA with cholera toxin (CT). Eyedrop influenza A/PR/8 virus (H1N1) both virus-specific systemic responses protected mice completely respiratory virus. In addition, attenuated...

To compare the objective assessment of lens density by 2 systems (double-pass Optical Quality Analysis System and Pentacam Scheimpflug) in eyes with age-related nuclear cataract.Department Ophthalmology Visual Science, Seoul St. Mary's Hospital, College Medicine, The Catholic University Korea, Seoul, South Korea.Cross-sectional study.In cataract, (0 to 100 points) was determined using Scheimpflug system while subjective grading achieved Lens Opacities Classification III (LOCS III). scatter...

Autophagy is known to be implicated in the pathogenesis of Sjögren syndrome (SS), but evidences are limited. We aimed examine levels autophagy markers tear film and conjunctival epithelial cells from SS dry eye patients, analyze their correlations with clinical features. Patients exhibited lower Schirmer values, breakup time, higher ocular staining scores. In tears, ATG5 LC3B-II/I were significantly eye. LC3B-II mRNA conjunctiva also elevated compared non-SS The immunostaining epithelium...

To evaluate the relationship between lens density measured using Pentacam Scheimpflug system and phacodynamics (phacoemulsification time, phacoemulsification energy, balanced salt solution [BSS] use) in patients with age-related nuclear cataract.Department of Ophthalmology Visual Science, Kangnam St. Mary's Hospital, College Medicine, The Catholic University Korea, Seoul, Korea.This prospective observer-masked study was eyes cataract. Objective (0 to 100 points) determined system. Subjective...

The aim of this study was to evaluate the prevalence long-term recurrence after topical nonpreserved methylprednisolone pulse therapy for treatment keratoconjunctivitis sicca (KCS) with Sjögren's syndrome.A total 106 eyes 53 syndrome patients were included in study. All treated 1% solution. Initial consisted eyedrops 4 times a day 2 weeks, and then reevaluated tapered off medication every weeks until discontinuation. Tear film breakup time (TBUT), Schirmer test, corneal fluorescein staining,...

Although some studies have reported that preoperative vitamin D deficiency (VDD) is a risk factor for hypocalcemia after total thyroidectomy (TT) in patients with nontoxic multinodular goiter or Graves' disease, the association between VDD and postoperative thyroid cancer undergoing TT plus central compartment neck dissection (CCND) remains unclear. This study evaluated whether was associated symptomatic hypocalcemia.Data were collected prospectively September 2012 May 2013. A of 267...

We investigated the utility of a combination autologous serum eye drops and silicone-hydrogel (SH) lens in treatment persistent epithelial defects (PEDs).Eight patients who had distinct PED conditions were treated with 50% (v/v) silicone hydrogel contact lenses prospectively observed.The pathogenesis PEDs included Sjogren-type dry syndrome, graft-versus-host disease, toxic keratitis, limbal cell deficiency, superior limbic keratoconjunctivitis, neurotrophic keratitis. The for 90±81.76 days...

To investigate the expression levels of inflammatory cytokines in conjunctival epithelium and correlations with clinical parameters dry eye disease (DED).This study evaluated 28 patients Sjögren syndrome (SS) DED, non-SS 10 controls. The messenger ribonucleic acid (mRNA) such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6, interferon (IFN)-γ, IL-17, matrix metalloproteinase 9 (MMP9) from was investigated by real-time polymerase chain reaction. Protein confirmed immunofluorescence...

Sjögren’s syndrome (SS) is a systemic autoimmune disease delineated by chronic lymphocytic infiltrates into the lacrimal or salivary glands, leading to severe dry eye and mouth. Mesenchymal stem cells have been shown be effective in treating numerous diseases. This study aimed illustrate effects of mesenchymal on attenuation eyes (DE) through inhibition autophagy markers SS mouse model. NOD/ShiLtJ female mice with developed DE were treated either subconjunctival gland injections hMSCs...

We describe here the organization of calmodulin genes Trypanosoma cruzi and their linkage to ubiquitin gene family. The nucleotide sequence CalA2 has been determined is 85% homologous protein coding African trypanosome, brucei. proteins encoded by T. brucei contain a single mismatch out total 149 amino acids. genome contains eight present at two distinct loci (2.8 2.65) each which linked downstream genes. Within locus families have defined, CalA CalB. Each consist alternating tandem arrays...

PURPOSE: To compare the higher-order aberrations (HOAs) in 70 eyes (38 patients) that had wavefront-guided laser situ keratomileusis (LASIK) with those (40 laser-assisted subepithelial keratectomy (LASEK) for treatment of myopia. SETTING: Department Ophthalmology, Yonsei University College Medicine, Myongdong Bal-geun sesang Eye Clinic, and Seran Center, Seoul, Korea. METHODS: In a prospective study, 140 consecutive 78 patients were treated LASIK or LASEK according to patient's choice after...

Abstract We compared the efficacy and safety of autologous-serum (AS) platelet-rich plasma (PRP) eye drops for dry (DE) treatment in primary Sjögren’s syndrome (SS). This prospective, randomized, double-blinded clinical study included patients diagnosed with SS DE. Thirty-eight participants were randomly assigned to AS or PRP groups. Corneal conjunctival staining scores, Schirmer I test, tear film break-up time (TBUT), ocular surface disease index (OSDI) scores evaluated at 4 12 weeks....

Background: Papillary thyroid carcinoma (PTC) is the most frequent of gland and has a relatively good prognosis. However, it important to identify PTC characteristics that indicate high risk for recurrence metastasis. To date, overexpression membrane mucin, MUC1, been investigated as key molecular event in pathogenesis aggressive PTC. other membrane-associated mucins, matrix metalloproteinase-13 (MMP-13) tissue inhibitor (TIMP-3), have not studied yet. The aim this study was evaluate...

We compared the 3-year outcomes with regard to efficacy, stability, and safety of LASIK surface ablation performed at multiple centers in Korea.The charts 5109 eyes that underwent or ablation, including LASEK, epi-LASIK, photorefractive keratectomy (PRK), between 2002 2005 were reviewed. Of these, 577 LASIK-treated propensity score-matched surface-ablated included this cohort study. A standardized case report form (CRF) was completed based on a review follow-up chart. The CRF preoperative,...

IL-21 plays an important role in primary Sjögren syndrome (SS) pathogenesis. The purpose of this study was to evaluate expression tears and the conjunctiva analyze impact on SS dry eyes.Eighty subjects were enrolled study: 30 patients with eye (30 eyes); non-SS eyes), 20 normal controls. Tear levels measured by flow cytometry, gene from impression cytology evaluated quantitative polymerase chain reaction. Ocular Surface Disease Index, tear film breakup time, Schirmer I test, ocular surface...

Purpose: To assess the predictive accuracy of 4 no-history intraocular lens (IOL) power formulas in eyes with prior myopic excimer laser surgery, classified groups according to their axial length (AL), and investigate relationship between AL accuracy. Setting: Seoul St. Mary's Hospital, Republic Korea. Design: Retrospective case series. Methods: IOL was calculated Barrett True-K, Haigis-L, Shammas-PL, Triple-S AL. Primary outcomes were median absolute error (MedAE) percentage a prediction...

The aim of this paper is to demonstrate the safety and use transcaruncular approach as a surgical technique for managing medial wall fracture. This was used in 40 patients with isolated or combined inferior orbital fracture between September 1998 2002. A computed tomographic scan taken before after surgery. ocular motility enophthalmos were checked provided appropriate exposure all cases. Patients followed up mean 9.4 months (range, 5–24 months) repairing Hertel exophthalmometry showed that...

To evaluate the efficacy and safety profile of carbomer-based lipid-containing artificial tear formulations (CBLAT) in patients with dry eye syndrome.A multicenter parallel-group study was conducted 412 syndrome. Of these patients, 221 switched from using tears to CBLAT (switching group) 191 added their current treatment (add-on group). Ocular symptom scores, ocular staining grades, film breakup time (tBUT), Schirmer I test value, Korean level (as defined by Corneal Disease Study Group...