A5089189563- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Muscle Physiology and Disorders
- Retinal Development and Disorders
- Synthesis and biological activity
- Pancreatic and Hepatic Oncology Research
- Adipose Tissue and Metabolism
- Cervical Cancer and HPV Research
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Cancer therapeutics and mechanisms
- Mitochondrial Function and Pathology
- Signaling Pathways in Disease
- Invertebrate Immune Response Mechanisms
- Retinopathy of Prematurity Studies
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Cellular transport and secretion
- Alzheimer's disease research and treatments
- Microtubule and mitosis dynamics
Weizmann Institute of Science
2021-2025
Instituto de Neurociencias
2024
Consejo Superior de Investigaciones Científicas
2024
University of Alicante
2013-2021
Leiden University Medical Center
2020-2021
Hospital Universitario La Paz
2016
Universidad de Antioquia
2012
The technical capability of different methods to diagnose Plasmodium in maternal peripheral blood, placenta, and umbilical cord blood has not been assessed Colombia seldom explored other malaria-endemic regions. We designed a study compare the operational-economical performances light microscopy (LM), nested polymerase chain reaction (nPCR), histopathology (HP). In LM had 41% sensitivity 100% specificity placental 35% 100%, respectively, compared with nPCR. tissue, 33% 95% specificity; nPCR...
Estimating the type-specific prevalence of human papillomavirus (HPV) in head and neck cancer (HNSCC) is helpful predicting impact HPV immunization. To estimate overall prevalence, gender age-specific HNSCC. This cross sectional retrospective study was carried out four pathology laboratories Medellin, Colombia. testing performed by GP5+/6+ PCR-based RLB 16 18 PCR. 175 primary HNSCC cases consecutively diagnosed between 1999 2008 with confirmed diagnosis amplifiable DNA were included. Overall...
Cellular plasticity mediates tissue development as well cancer growth and progression. In breast cancer, a shift to more epithelial phenotype (epithelialization) underlies state of reversible cell arrest called tumor dormancy, which enables drug resistance, recurrence, metastasis. Here, we explored the mechanisms driving epithelialization dormancy in aggressive mesenchymal-like cells three-dimensional cultures. Overexpressing either lineage-associated transcription factors OVOL1 or OVOL2...
Some antibacterial therapies entail sequential treatments with different antibiotics, but whether this approach is optimal for anti-cancer tyrosine kinase inhibitors (TKIs) remains open. EGFR mutations identify lung cancer patients who can derive benefit from TKIs, most develop resistance to the first-, second-, and third-generation drugs. To explore alternatives such whack-a-mole strategies, we simulated in patient-derived xenograft models situation of receiving first-line TKIs....
Abstract Hypoglycosylation of α-dystroglycan (α-DG) resulting from deficiency protein O-mannosyltransferase 1 (POMT1) may cause severe neuromuscular dystrophies with brain and eye anomalies, named dystroglycanopathies. The retinal involvement these disorders motivated us to generate a conditional knockout (cKO) mouse experiencing Pomt1 intragenic deletion (exons 3–4) during the development photoreceptors, mediated by Cre recombinase expressed cone-rod homeobox ( Crx ) gene promoter. In this...
Examination of genes repressed hours after exposure to the growth factor EGF reveals that TSHZ2 restricts mitosis.
Lung cancers driven by mutant forms of EGFR invariably develop resistance to kinase inhibitors, often due secondary mutations. Here we describe an unconventional mechanism dacomitinib, a newly approved covalent inhibitor, and uncover previously unknown step acquisition. Dacomitinib-resistant (DR) derivatives lung cancer cells were established means gradually increasing dacomitinib concentrations. These DR acquired no mutations in the or other domains EGFR. Along with features characteristic...
Cell death is an essential physiological process for the survival of multicellular organisms. Our understanding programmed cell in development, immune function maintenance, and adult tissue repair has significantly advanced over past decade. However, there are still gaps our knowledge about induction, regulation, checkpoints this due to diverse forms cellular suicide rapid nature process. Molecular advancements such as specific sensors, RNA-seq, single-cell proteomics have allowed...
Mutations in the POMT1 gene, encoding a protein O-mannosyltransferase essential for α-dystroglycan (α-DG) glycosylation, are frequently observed group of rare congenital muscular dystrophies, collectively known as dystroglycanopathies. However, it is hitherto unclear whether effects seen affected patients can be fully ascribed to α-DG hypoglycosylation. To study this, here we used comparative mass spectrometry-based proteomics and immunofluorescence microscopy investigated changes retina...
<div>Abstract<p>Lung cancers driven by mutant forms of EGFR invariably develop resistance to kinase inhibitors, often due secondary mutations. Here we describe an unconventional mechanism dacomitinib, a newly approved covalent inhibitor, and uncover previously unknown step acquisition. Dacomitinib-resistant (DR) derivatives lung cancer cells were established means gradually increasing dacomitinib concentrations. These DR acquired no mutations in the or other domains EGFR. Along...
<p>Supplementary Figures 1~11</p>
<div>Abstract<p>Lung cancers driven by mutant forms of EGFR invariably develop resistance to kinase inhibitors, often due secondary mutations. Here we describe an unconventional mechanism dacomitinib, a newly approved covalent inhibitor, and uncover previously unknown step acquisition. Dacomitinib-resistant (DR) derivatives lung cancer cells were established means gradually increasing dacomitinib concentrations. These DR acquired no mutations in the or other domains EGFR. Along...
<p>Supplementary Figures 1~11</p>
<p>Supplementary Materials and Methods</p>