Feride Karatekin
A5115948902- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
Weizmann Institute of Science
2025
Approximately 50% of prostate cancer (PCa) patients harbor fusions involving the TMPRSS2 and ERG genes. Despite this, tailored therapies targeting fused gene, tERG, remain undeveloped. Our study analyzed biopsy samples from two clinical trials assessing efficacies androgen receptor (AR) signaling inhibitors (ARSIs). The results revealed that tERG promotes resistance to ARSIs is associated with elevated levels glucocorticoid (GR). Subsequent assays showed GR directly interacts alleviates...
Abstract Epithelial lineage differentiation is pivotal to mammary gland development and it can pause metastasis of breast cancer (BC) by inducing tumor dormancy. To simulate this, we expressed epithelial genes in mesenchymal BC cells. Inducible expression the OVOL metastatic cells suppressed proliferation migration. We found that C1ORF116 , an OVOL’s target, susceptible genetic epigenetic aberrations BC. It regulated steroids functions as a putative autophagy receptor inhibits antioxidants...
Cellular plasticity mediates tissue development as well cancer growth and progression. In breast cancer, a shift to more epithelial phenotype (epithelialization) underlies state of reversible cell arrest called tumor dormancy, which enables drug resistance, recurrence, metastasis. Here, we explored the mechanisms driving epithelialization dormancy in aggressive mesenchymal-like cells three-dimensional cultures. Overexpressing either lineage-associated transcription factors OVOL1 or OVOL2...