A5102852128- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Immune cells in cancer
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related gene regulation
- RNA modifications and cancer
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Nuclear Receptors and Signaling
- Immune responses and vaccinations
- RNA Interference and Gene Delivery
- Silicon Carbide Semiconductor Technologies
- Probiotics and Fermented Foods
- Inflammatory Biomarkers in Disease Prognosis
- Botulinum Toxin and Related Neurological Disorders
- Cervical Cancer and HPV Research
- Psoriasis: Treatment and Pathogenesis
- Advancements in Semiconductor Devices and Circuit Design
Seoul National University
2014-2025
Kyung Hee University
2025
University of California, San Diego
2019-2025
La Jolla Institute for Immunology
2019-2023
Hanyang University
2023
National Center for Global Health and Medicine
2019
Keio University
2019
Namseoul University
2017-2018
The recent advent of DNA sequencing technologies facilitates the use genome data that provide means for more informative and precise classification identification members Bacteria Archaea. Because current species definition is based on comparison sequences between type other strains in a given species, building database with correct taxonomic information paramount need to enhance our efforts exploring prokaryotic diversity discovering novel as well routine identifications. Here we introduce...
T cells expressing chimeric antigen receptors (CAR cells) have shown impressive therapeutic efficacy against leukemias and lymphomas. However, they not been as effective solid tumors because become hyporesponsive ("exhausted" or "dysfunctional") within the tumor microenvironment, with decreased cytokine production increased expression of several inhibitory surface receptors. Here we define a transcriptional network that mediates CD8+ cell exhaustion. We show high-mobility group (HMG)-box...
Abstract During cancer immunoediting, loss of major histocompatibility complex class I (MHC-I) in neoplasm contributes to the evasion tumours from host immune system. Recent studies have demonstrated that most natural killer (NK) cells are found advanced cancers defective, releasing malignant MHC-I-deficient NK-cell-dependent control. Here, we show a T (NKT)-cell-ligand-loaded tumour-antigen expressing antigen-presenting cell (APC)-based vaccine effectively eradicates these tumours. this...
Cancer genomes are characterized by focal increases in DNA methylation, co-occurring with widespread hypomethylation. Here, we show that TET loss of function results a similar genomic footprint. Both 5hmC wild-type (WT) and hypermethylation -deficient largely confined to the active euchromatic compartment, consistent known functions proteins demethylation distribution at transcribed genes enhancers. In contrast, an unexpected hypomethylation noted multiple is primarily observed...
T cell exhaustion, which is observed in various chronic infections and malignancies, characterized by elevated expression of multiple inhibitory receptors, impaired effector functions, decreased proliferation, reduced cytokine production. Notably, while adoptive therapies, such as chimeric antigen receptor (CAR)-T therapy, have shown promise treating cancer other diseases, the efficacy these therapies often compromised exhaustion. It imperative, therefore, to understand mechanisms underlying...
Studies over the last 2 decades have identified IL-17 and IL-21 as key cytokines in modulation of a wide range immune responses. serves critical defender against bacterial fungal pathogens, while maintaining symbiotic relationships with commensal microbiota. However, alterations its levels can lead to chronic inflammation autoimmunity. IL-21, on other hand, bridges adaptive innate responses, imbalance is implicated autoimmune diseases cancer, highlighting important role both health disease....
PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism action. Here, we show that acts upstream PD-1 and requires co-ligation the cell receptor (TCR) to attenuate activation mouse human CD8+ cells drive terminal exhaustion. directly restrains TCR signaling via Zap70 maintains expression inhibitor Sts-1. deficiency empowers respond low-affinity ligands inhibit growth PD-1-blockade-resistant melanoma by enabling tumor-infiltrating...
Abstract PD-1–based cancer immunotherapy is a successful example of immune checkpoint blockade that provides long-term durable therapeutic effects in patients with across wide spectrum types. Accumulating evidence suggests anti-PD-1 therapy enhances antitumor immunity by reversing the function exhausted T cells tumor environment. However, responsiveness rate to remains low, providing an urgent need for optimization and improvement. In this study, we designed anti-PD-1–resistant mouse model...
Abstract Increased expression of coinhibitory molecules such as PD-1 and Tim-3 on NK cells has been demonstrated in advanced cancer patients who harbor MHC class I–deficient tumors. However, even preclinical models, the antitumor effects checkpoint blockade have not clearly elucidated. Here, we show that anti–PD-1/anti–Tim-3 treatment suppressed tumor progression mice bearing tumors, suppression was further enhanced by recombinant IL21 (rIL21) treatments through an NK-cell–dependent...
Myeloid-derived suppressor cells (MDSCs), which suppress diverse innate and adaptive immune responses thereby provide an evasion mechanism for tumors, are emerging as a key population linking inflammation to cancer. Although many inflammatory factors that induce MDSCs in the tumor microenvironment known, crucial components underlying mechanisms remain elusive. In this study, we proposed novel by serum amyloid A3 (SAA3), well-known factor, connects with cancer progression. We found SAA3...
Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased the secondary lymphoid organs acute LCMV infection an interferon-γ (IFN-γ)-dependent manner. We also priming by enhanced differentiation of memory CD8+ T compared primed conventional (cDCs) through upregulation Eomesodermin (Eomes) and cell factor-1 (TCF-1) expression cells....
<p>Supplementary Figures</p>
<div>Abstract<p>PD-1–based cancer immunotherapy is a successful example of immune checkpoint blockade that provides long-term durable therapeutic effects in patients with across wide spectrum types. Accumulating evidence suggests anti-PD-1 therapy enhances antitumor immunity by reversing the function exhausted T cells tumor environment. However, responsiveness rate to remains low, providing an urgent need for optimization and improvement. In this study, we designed...
Myelin enables rapid impulse propagation in axons across long distances. Following peripheral nerve injury, Schwann cells provide trophic, metabolic, and immune support to damaged neurons. To facilitate myelin repair, activate a robust transcriptional program, including the tissue inhibitor of metalloproteinase (TIMP)-1 gene. TIMP-1 is potent protease neurotrophic factor, traditionally known as secreted protein. This study presents first evidence myelin/membrane lipid raft-associated...
GM-CSF as an adjuvant has been shown to promote antitumor immunity in mice and humans; however, the underlying mechanism of GM-CSF-induced remains incompletely understood. In this study, we demonstrate that potentiates efficacy cancer vaccines through IL9-producing Th (Th9) cells. selectively enhanced Th9 cell differentiation by regulating COX2-PGE2 pathway while inhibiting induced regulatory T (iTreg) cells vitro vivo GM-CSF-activated monocyte-derived dendritic converted tumor-specific...
Uncontrolled macrophage functions cause failure to resolve gut inflammation and has been implicated in the pathogenesis of inflammatory bowel disease (IBD). 15-Deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ ), one endogenous lipid mediators formed from arachidonic acid during process, reported terminate inflammation. However, pro-resolving effect 15d-PGJ on intestinal underlying molecular mechanisms remain largely unknown. In present study, we examined effects resolution dextran sulfate sodium...
Here, this study verifies that cancer-associated thrombosis (CAT) accelerates hypoxia, which is detrimental to the tumor immune microenvironment by limiting perfusion. Therefore, we designed an oral anticoagulant therapy improve immunosuppressive and potentiate efficacy of immunotherapy alleviating hypoxia. A novel (STP3725) was developed consistently prevent CAT formation. Tumor perfusion hypoxia were analyzed with or without treating STP3725 in wild-type P selectin knockout mice....
Although treatment with the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) agonistic antibody (DTA-1) has shown antitumor activity in various models, underlying mechanism is not fully understood. Here, we demonstrate that interleukin (IL)-21-producing follicular helper T (Tfh) cells play a crucial role DTA-1-induced inhibition. The administration of DTA-1 increased IL21 expression by Tfh an antigen-specific manner, and this activation led to enhanced cytotoxic...