A5101542859- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- CAR-T cell therapy research
- Flowering Plant Growth and Cultivation
- Plant Physiology and Cultivation Studies
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Blood disorders and treatments
- Adenosine and Purinergic Signaling
- Banana Cultivation and Research
- Proteoglycans and glycosaminoglycans research
- Plant tissue culture and regeneration
- Genetics and Plant Breeding
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal and related cancers
- Soybean genetics and cultivation
- Genetic factors in colorectal cancer
- Agricultural Practices and Plant Genetics
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Agriculture and Biological Studies
- Signaling Pathways in Disease
- Agriculture, Plant Science, Crop Management
- Carbohydrate Chemistry and Synthesis
National Cancer Institute
2018-2024
Center for Cancer Research
2018-2024
National Institutes of Health
2018-2024
Odisha University of Agriculture and Technology
2014-2022
National Institute of Immunology
2014-2020
T cells expressing chimeric antigen receptors (CAR cells) have shown impressive therapeutic efficacy against leukemias and lymphomas. However, they not been as effective solid tumors because become hyporesponsive ("exhausted" or "dysfunctional") within the tumor microenvironment, with decreased cytokine production increased expression of several inhibitory surface receptors. Here we define a transcriptional network that mediates CD8+ cell exhaustion. We show high-mobility group (HMG)-box...
Lung group 2 innate lymphoid cells (ILC2s) drive allergic inflammation and promote tissue repair. ILC2 development is dependent on the transcription factor retinoic acid receptor–related orphan receptor (RORα), which also expressed in common ILC progenitors. To elucidate developmental pathways of lung ILC2s, we generated RORα lineage tracer mice performed single-cell RNA sequencing, flow cytometry, functional analyses. In adult mouse lungs, found an IL-18Rα+ST2− population different from...
Significance Since fever is frequently a response to infection, immune responses likely occur commonly at temperatures. Are temperatures detected by cells, what molecular pathways are involved in this sensing, and the functional consequences? Our data show that CD4 T lymphocytes detect moderate temperature. A TRPV channel-mediated pathway involving Notch activation leads Th2 skewing of effector cell response. However, antigen presenting dendritic cells stimulate turn, temperature overproduce...
Abstract Small numbers of hematopoietic stem cells (HSCs) balance self-renewal and differentiation to produce the diversity abundance cell types that make up blood system. How nutrients are recruited support this massive proliferation process remains largely unknown. The unique metabolism adult HSCs, which rely on glycolysis glutaminolysis, suggests a potential role for post-translational modification O -GlcNAc as critical nutrient signal in these cells. Glutamine, glucose, other metabolites...
An experiment was carried out in the College of Agriculture, Orissa University Agriculture and Technology, Bhubaneswar during Rabi 2012-13.The comprised 11 treatments replicated three times a Randomized Block Design.Of eleven seven 100 per cent NPK with or without organic nutrient supplements, two 50 +organic one treatment no nutrients (T 1 -control), only biofertilizers.The T 7 which (@150-38-63 kg ha -1 ) application along vermicompost (@ 2.5 t ), biofertilizer @2 each Azotobacter,...
Naïve CD4 T (NCD4T) cells post-activation undergo programming for inducible production of cytokines leading to generation memory with various functions. Based on cytokine based polarization NCD4T in vitro, either 'Th1' (interferon-gamma [IFNg]) or 'Th2' (interleukin [IL]-4/5/13) is thought occur via mutually exclusive expression and functioning T-bet GATA-3 transcription factors (TFs). However, we show that a high proportion mouse human memory-phenotype (MCD4T) generated vivo which expressed...
Thymic epithelial cells (TEC) control T cell development and play essential roles in establishing self-tolerance. By using
Analysis of the transcriptional profiles developing thymocytes has shown that T lineage commitment is associated with loss stem cell and early progenitor gene signatures acquisition signatures. Less well understood are epigenetic alterations accompany or enable these changes. Here, we show histone demethylase Lsd1 (Kdm1a) performs a key role in extinguishing stem/progenitor programs addition to repressive during thymocyte maturation. Deletion caused block late development resulted...
As individual naïve CD4 T lymphocytes circulate in the body after emerging from thymus, they are likely to have individually varying microenvironmental interactions even absence of stimulation via specific target recognition. It is not clear if these result alterations their activation, survival and effector programming. Naïve cells show unimodal distribution for many phenotypic properties, suggesting that variation caused by intrinsic stochasticity, although underlying due subsets created...
HIV-1 encodes accessory proteins that neutralize antiviral restriction factors to ensure its successful replication. One protein, the viral infectivity factor (Vif), is known promote ubiquitination and proteasomal degradation of apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G), a cytosine deaminase leads hypermutations in DNA subsequent aberrant We have previously demonstrated transcription mediator Tat activates host progrowth PI-3-AKT pathway, which turn...
Abstract Adoptive cell therapy with chimeric antigen receptor expressing T (CAR T) cells has shown promising therapeutic efficacy against leukemia and lymphoma. However, CAR in solid tumors fail to be as effective liquid since they enter into a hyporesponsive (exhausted or dysfunctional) state that is induced by chronic stimulation cancer. Here, we show exhibit low effector function high expression of inhibitory receptors such PD-1, Tim-3 Lag 3. We also the nuclear factor, Thymocyte...
Abstract T cells expressing chimeric antigen receptors (CARs) have shown impressive therapeutic efficacy against leukemias and lymphomas, but not been as effective solid tumors because chronic stimulation with tumor antigens causes them to enter a hyporesponsive (“exhausted” or “dysfunctional”) state. Here we show that the high-mobility group (HMG)-box transcription factors TOX TOX2 are highly expressed in CAR-expressing exhausted (PD-1highTim3high) CD8+ tumor-infiltrating lymphocytes...
IBA 5000 ppm produced maximum rooted layer (90.00%) in litchi cv.PURBI.IBA also proved better producing more number of roots per (44.87), root length (4.67) and new leaves (7.44).The were thinner treated marcots (0.57 mm).