Jonathan Hubb
A5016093074- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- HIV Research and Treatment
- Animal Virus Infections Studies
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Plant Virus Research Studies
- HIV/AIDS Research and Interventions
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Infectious Diseases and Tuberculosis
- COVID-19 and healthcare impacts
- CRISPR and Genetic Engineering
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Immune responses and vaccinations
- Mycobacterium research and diagnosis
- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
Public Health England
2021-2022
Imperial College London
2022
Quadram Institute
2022
ZOE (United Kingdom)
2021
Barts Health NHS Trust
2015-2018
University of Cambridge
2005
Background. An 18-month-old boy developed encephalopathy, for which extensive investigation failed to identify an etiology, 6 weeks after stem cell transplant. To exclude a potential infectious cause, we performed high-throughput RNA sequencing on brain biopsy.
The ICONIC project has developed an automated high-throughput pipeline to generate HIV nearly full-length genomes (NFLG, i.e. from gag nef) next-generation sequencing (NGS) data. was applied 420 samples collected at University College London Hospitals NHS Trust and Barts Health (London) sequenced using Illumina MiSeq the Wellcome Sanger Institute (Cambridge). Consensus were generated subtyped COMET, unique recombinants studied with jpHMM SimPlot. Maximum-likelihood phylogenetic trees...
Using deep sequencing, human immunodeficiency virus (HIV) resistance-associated mutations were detected as minority species in the cerebrospinal fluid (CSF) of 4 patients with higher HIV type 1 RNA load CSF than plasma, but not 2 plasma viral load. Deep sequencing could help our understanding escape central nervous system.
Abstract Background Drug-resistant minority variants (DRMinVs) detected in patients who recently acquired human immunodeficiency virus type 1 (HIV-1) can be transmitted, generated de novo through replication, or technical errors. The first form is likely to persist and result treatment failure, while the latter two could stochastic transient. Methods Ultradeep sequencing of plasma samples from 835 individuals with recent HIV-1 infection United Kingdom was performed detect DRMinVs at a...
In subjects with transmitted thymidine analogue mutations (TAMs), boosted PIs (PI/b) are often chosen to overcome possible resistance the NRTI backbone. However, data guide treatment selection limited. Our aim was obtain firmer guidance for clinical practice using real-world cohort data. We analysed 1710 who started a PI/b in combination tenofovir or abacavir plus emtricitabine lamivudine, and compared their virological outcomes those of 4889 patients an NNRTI (predominantly efavirenz),...
Abstract Background & Methods The ICONIC project has developed an automated high-throughput pipeline to generate HIV nearly full-length genomes (NFLG, i.e. from gag nef ) next-generation sequencing (NGS) data. was applied 420 samples collected at University College London Hospital and Barts Health NHS Trust (London) sequenced using Illumina MiSeq the Wellcome Sanger Institute (Cambridge). Consensus were generated subtyped COMET, unique recombinants studied with jpHMM SimPlot....
Colonized travelers contribute to the pandemic spread of resistant intestinal bacteria.This study is first show that antimicrobial use during travel predisposes