A5011110710- Polysaccharides and Plant Cell Walls
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Ultrasound Imaging and Elastography
- Polysaccharides Composition and Applications
- Colorectal Cancer Screening and Detection
- Seaweed-derived Bioactive Compounds
- Plant Reproductive Biology
- Ultrasound and Hyperthermia Applications
- Galectins and Cancer Biology
- Liver Disease Diagnosis and Treatment
- Fern and Epiphyte Biology
- Marine and coastal plant biology
- Plant Diversity and Evolution
- Legume Nitrogen Fixing Symbiosis
- Toxin Mechanisms and Immunotoxins
- Gallbladder and Bile Duct Disorders
- Viral gastroenteritis research and epidemiology
- Plant Pathogens and Fungal Diseases
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glycosylation and Glycoproteins Research
- Plant nutrient uptake and metabolism
- Coastal wetland ecosystem dynamics
Kiel University
2019-2025
Krankenhaus Barmherzige Brüder
2021-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2024
German Cancer Research Center
2023
University Hospital Heidelberg
2023
Heidelberg University
2023
Universitätsklinikum Erlangen
2014-2015
Institute of Medical Microbiology and Hygiene
2013
Technical University of Munich
2013
University of Saskatchewan
2010
Zygnematophytes are the closest algal relatives of land plants. They hold key information to infer how earliest plants overcame barrage terrestrial stressors, prime which is osmotic stress. Here, we applied two stressors on a unicellular and multicellular representative zygnematophytes studied their response over 25-hour time course generating 130, 60, 30 transcriptomic, proteomic, metabolomic samples combined with photophysiology, sugar analysis, immunocytochemical glycoprotein microscopy....
A Strep tamer-based k off rate assay identifies T cells with high protective capacity for the adoptive transfer.
Abstract Seagrasses evolved from monocotyledonous land plants that returned to the marine habitat. This transition was accomplished by substantial changes in cell wall composition, revealing habitat-driven adaption new environment. Whether arabinogalactan-proteins (AGPs), important signalling molecules of plants, are present seagrass walls is evolutionary and plant development interest. AGPs Zostera marina L. were isolated structurally characterised analytical bioinformatics methods as well...
Artificial intelligence (AI) in gastrointestinal endoscopy is developing very fast. Computer-aided detection of polyps and computer-aided diagnosis (CADx) for polyp characterization are available now. This study was performed to evaluate the diagnostic performance a new commercially CADx system clinical practice.
SUMMARY Significant changes have occurred in plant cell wall composition during evolution and diversification of tracheophytes. As the sister lineage to seed plants, knowledge on ferns is key track evolutionary across tracheophytes understand plant‐specific innovations. Fern not fully understood, including limited glycoproteins such as fern arabinogalactan proteins (AGPs). Here, we characterize AGPs from leptosporangiate genera Azolla , Salvinia Ceratopteris . The carbohydrate moiety...
To explore the impact of cholestasis on liver stiffness assessed by acoustic radiation force impulse (ARFI) technology.Over a period four months, patients with sonographic and increased cholestatic blood values (Bilirubin, γGT, AP > 2 times ULN) scheduled for endoscopic therapy were recruited. Exclusion criteria were: known disease; signs cirrhosis at ultrasound (irregular veins and/or surface); heart insufficiency (NYHA III-VI). ARFI (Siemens S2000), examinations performed before in...
Streptophyte algae are the closest relatives to land plants; their latest common ancestor performed most drastic adaptation in plant evolution around 500 million years ago: conquest of land. Besides other adaptations, this step required changes cell wall composition. Current knowledge on walls streptophyte and especially presence arabinogalactan-proteins (AGPs), important signalling molecules all plants, is limited. To get deeper insights into algae, Charophyceae, we sequential extractions...
Abstract During the late cretaceous period several lineages of angiosperm plants transitioned from land to sea by successfully adapting life in salt water, forming polyphyletic group seagrasses. Today, four seagrass families inhabit coastal systems and are deeply intertwined with health welfare these ecosystems. Adaptation ocean environment included changes composition plant cell walls associated glycoproteins. We have asked question whether or not there is a convergent similar...
Abstract Galectins are β-galactoside-binding proteins with numerous functions. Some of them involved in proliferation and metastasis cancer, making promising therapeutic targets. As different plant glycans have been shown to bind galectins, saccharides might be potential galectin inhibitors. To produce galactans rich galactose smaller size, we degraded arabinogalactan-proteins from Echinacea purpurea Zostera marina as well arabinogalactan larch. (Gal)-3 -9 both described cancer development,...
Two bryophyte models, the hornwort Anthoceros agrestis (Anthoceros) and moss Physcomitrium patens (Physcomitrium), were analysed for presence of arabinogalactan-proteins (AGPs), as emergence these signalling glycoproteins in evolution is still under debate. AGPs both species had a galactan core structure similar to that other fern AGPs, but different angiosperm 1,6-linked pyranosidic galactose was almost absent. In AGP, furanosidic arabinose (Araf) linkages mainly terminal (10 %) or 5-linked...
In the work-up of focal pancreatic lesions autoimmune pancreatitis (AIP) is a rare differential diagnosis to cancer (PC) with similar clinical constellations. The aim our study was compare differences between proven AIP and PC using transabdominal dynamic contrast enhanced ultrasound (DCE-US). Therefore we recorded 3-minute-clips CEUS examinations analyzed perfusion parameters VueBox<sup>®</sup>-quantification software. To obtain DCE-US Parameters, Regions-of-Interest were selected within...
Charophyte green algae (CGA) are assigned to be the closest relatives of land plants and therefore enlighten processes in colonization terrestrial habitats. For transition from water land, needed significant physiological structural changes, as well with regard cell wall composition. Sequential extraction walls Nitellopsis obtusa (Charophyceae) Spirogyra pratensis (Zygnematophyceae) offered a comparative overview on composition late branching CGA. Because arabinogalactan-proteins (AGPs)...
Abstract Despite ferns being crucial to understanding plant evolution, their large and complex genomes has kept genetic landscape largely uncharted, with only a handful of sequenced sparse transcriptomic data. Addressing this gap, we generated extensive RNA-sequencing data for multiple organs across 22 representative species over the fern phylogeny, assembling high-quality transcriptomes. These facilitated construction time-calibrated phylogeny covering all major clades, revealing numerous...
Objective The incidence of intrahepatic cholangiocarcinoma (iCCA) has been increasing over the past few decades. Liver cirrhosis is an independent risk factor for development iCCA. This study aimed to examine prognostic impact liver and patient condition on treatment Patients methods We retrospectively analyzed cases 156 patients diagnosed with iCCA between 1990 2014 in our center. were divided into subgroups depending presence severity type treatment. Clinical data, characteristics, overall...
Abstract Background The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment. Seagrasses form important coastal ecosystems worldwide and large amounts seagrass detritus washed on beaches might also be valuable bioeconomical resources. Despite this importance potential, little is known about adaptation these angiosperms environment their cell walls. Results We investigated polysaccharide composition nine species...
Objectives Two-dimensional shear-wave elastography (2D-SWE) is an ultrasound-based technique for the noninvasive assessment of tissue stiffness. In contrast to well-established point-shear-wave (pSWE) method acoustic radiation force impulse imaging, there little evidence on performance and usefulness 2D-SWE in liver Thus, aim our study was compare versus pSWE. Materials methods pSWE were performed 20 cirrhotic patients, healthy individuals elasticity phantom. Stiffness values, examination...
Aim The use of artificial intelligence represents an objective approach to increase endoscopist’s adenoma detection rate (ADR) and limit interoperator variability. In this study, we evaluated a newly developed deep convolutional neural network (DCNN) for automated colorectal polyps ex vivo as well in first in-human trial. Methods For training the DCNN, 116 529 colonoscopy images from 278 patients with 788 different were collected. A subset 10 467 containing 504 manually annotated treated...