A5000162966- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genital Health and Disease
- Cancer Risks and Factors
- Reproductive tract infections research
- Virus-based gene therapy research
- Pregnancy and preeclampsia studies
- Cancer-related Molecular Pathways
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Colorectal and Anal Carcinomas
- Molecular Biology Techniques and Applications
- Glycosylation and Glycoproteins Research
- Hepatitis B Virus Studies
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Parvovirus B19 Infection Studies
- Congenital Anomalies and Fetal Surgery
- Pelvic floor disorders treatments
Fujita Health University
2016-2025
Fujita Health University Hospital
2015-2024
Mie Agricultural Research Institute
2024
Fujita Health University Okazaki Medical Center
2024
University of Toyama
2022-2023
Keio University
2007-2016
Keio University Hospital
2013
Komatsu (Japan)
2013
Toin University of Yokohama
2005-2013
Hiratsuka Kyosai Hospital
2010
Aneuploidy in fetal chromosomes is one of the causes pregnancy loss and congenital birth defects. It known that frequency oocyte aneuploidy increases with human maternal age. Recent data have highlighted contribution cohesin complexes correct segregation meiotic chromosomes. In mammalian oocytes, cohesion established during stages meiosis-specific subunits are not replenished after birth, raising possibility long arrest oocytes facilitates a deterioration leads to age-related aneuploidy. We...
Only a subset of cervical precursor lesions progress to cancer and because the lack predictive markers, it cannot be ascertained which will or not. To estimate risk disease progression associated with human papillomavirus (HPV) genotypes, we followed 570 Japanese women cytological LSIL (low-grade squamous intraepithelial lesion) histological CIN (cervical neoplasia) grade 1-2 (479 1; 91 2) at 3 4 month intervals for mean follow-up period 39.1 months. At entry, detected HPV DNA in samples by...
Six years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by Japan Society Obstetrics and Gynecology Association Obstetricians Gynecologists, third revised published in 2017. 2017 Guidelines includes 10 additional clinical questions (CQ), brings total to 95 CQ (12 on infectious disease, 28 oncology benign tumors, 27 endocrinology infertility healthcare women). Currently a consensus has been reached therefore objective this report is present...
Overexpression of p16(INK4a) has been observed when retinoblastoma protein is inactivated by high-risk human papillomavirus (HPV) oncoprotein E7. We investigated overexpression and HPV infection in cervical squamous neoplasia to evaluate the oncogenic potential among various subtypes. The was detected PCR 69.8% (37/53), 97.5% (39/40), 91.7% (44/48), 100% (16/16) intraepithelial (CIN)1, CIN2, CIN3, cell carcinoma (SCC), respectively. immunohistochemically using a p16(INK4a)-specific...
Objective To investigate pregnancy outcomes in women after abdominal radical trachelectomy (RT) for early-stage cervical cancer. Methods The patients’ background, fertility, and were reviewed a total of 61 pregnancies 48 172 who underwent RT at Keio University Hospital between September 2002 December 2013. Results There 5 with stage IA1, 2 IA2, 41 IB1. Histological types as follows: squamous cell carcinoma (n = 36), adenocarcinoma 10), adenosquamous 2). rate attempting to conceive was 44%...
What are the reproductive and obstetric outcomes in patients undergoing radical abdominal trachelectomy (RAT) for early-stage cervical cancer?When RAT was performed before a pregnancy achieved with fertility treatments, rate of 36.2% obtained 71.4% these women gave birth at ≥ 32 weeks gestation.Reproductive after vaginal (RVT) well documented; however, have not been studied.This is retrospective cohort study single institution who underwent became pregnant. Reproductive 114 had undergone...
microRNAs (miRNAs) play important roles in regulation of gene expression during cervical carcinogenesis. We investigated profiles miRNAs cancer and its precursor lesions by utilizing mucus. Cervical mucus was collected from 230 patients with a normal cervix, intraepithelial neoplasia (CIN), squamous cell carcinoma (SCC), or adenocarcinoma (AD). The levels miRNA the were quantified array real-time reverse-transcriptase polymerase chain reaction (RT-PCR). performance for detecting diseases...
Abstract Twelve years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by Japan Society Obstetrics and Gynecology Association Obstetricians Gynecologists, 5th Revised Edition published in 2023. 2023 Guidelines includes 5 additional clinical questions (CQs), brings total to 103 CQ (12 on infectious disease, 30 oncology benign tumors, 29 endocrinology infertility 32 healthcare women). Currently, a consensus has been reached Guidelines, therefore,...
To examine the association between intrauterine manipulator use and pathological factors oncologic outcomes in patients with endometrial cancer who had laparoscopic hysterectomy Japan. This was a nationwide retrospective cohort study of tumor registry Japan Society Obstetrics Gynecology. Study population 3846 for from January 2015 to December 2017. An automated 1-to-1 propensity score matching preoperative intraoperative demographics performed assess postoperative associated manipulator....
The role of tobacco smoking in the multistage carcinogenesis at cervix is not fully understood because a paucity prospective data. To assess relationship between and spontaneous regression cervical precursor lesions, total 516 women with low‐grade squamous intraepithelial lesion (LSIL) were monitored by cytology colposcopy every 4 months. Probability LSIL within 2 years was analyzed relation to behaviors, defined as least two consecutive negative Pap smears normal colposcopy. Women’s age,...
Abstract Nine years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by Japan Society Obstetrics and Gynecology Association Obstetricians Gynecologists, 4th Revised Edition published in 2020. 2020 Guidelines includes 4 additional clinical questions (CQ), brings total to 99 CQ (12 on infectious disease, 29 oncology benign tumors, endocrinology infertility healthcare women). Currently, a consensus has been reached Guidelines, therefore, objective...
Abstract Purpose In the context of in vitro fertilization–embryo transfer (IVF–ET), factors other than egg quality may be key determinants treatment success, particular, maternal related to uterine endometrial receptivity and unidentified factors. We therefore aimed analyze metabolome microbiome IVF–ET patients who did not achieve pregnancy. Methods Cervicovaginal mucus was collected from undergoing IVF–ET. Metabolite analysis conducted by liquid chromatography‐mass spectrometry microbiota...
Human papillomavirus (HPV) 18 is related not only to squamous cell carcinoma of the cervix, but also adenocarcinoma and small in which prognosis known be poor. Small interfering RNA (siRNA) that targets HPV18 E6 E7 was tested HPV18-positive lines investigate its effect mechanism action. Nude mice were a combination siRNA atelocollagen determine whether it might useful as new molecule-targeting therapy for cervical cancer. siRNAs targeting transfected into cancer cells vitro they investigated...
<title>Abstract</title> <bold>Background: </bold>MicroRNAs (miRNAs) regulate gene expression in epithelial ovarian cancer (EOC). In a single-center, retrospective study, we aimed to assess serum miRNAs as EOC biomarkers, and whether combined antigen (CA)125 discriminated from benign tumors. <bold>Results: </bold>Sera were collected patients with (N=95) or tumors (N=115), healthy controls (N=40). Candidate screened by miRNA microarray quantified real-time reverse transcription (RT)-PCR. Serum...
As human papillomavirus (HPV) infection is the main risk factor for squamous cell carcinoma of cervix and overexpression p16INK4a occurs when retinoblastoma protein inactivated by high-risk HPV, authors studied association HPV expression in cervical adenocarcinomas. Specimens glandular neoplasias were immunostained with a p16INK4a-specific monoclonal antibody (clone E6H4). Approximately 80% neoplasms showed p16INK4a. Exfoliated cells from 14 adenocarcinomas further examined...
A relationship between inactivation of mitotic checkpoint genes and sensitivity cancer cells to anticancer agents has been reported. We investigated the effect epigenetic by aberrant hypermethylation gene CHFR (checkpoint with forkhead ring finger) on cervical taxanes. Methylation-specific PCR (MSP) smears showed methylation in 12.3% (2/14) adenocarcinoma specimens. In contrast, DNA was not detected normal or squamous cell carcinoma cells. Aberrant also analyzed 6 human carcinoma-derived...
Incidence of lymph node metastasis is relatively high even in early-stage epithelial ovarian cancers (EOC). Lymphadenectomy important the surgical treatment EOC; however, exact role lymphadenectomy management EOC remains unclear. In this study, we evaluated stages I and II patients.Seventy-nine patients with stage I/II underwent initial surgery, 68 received adjuvant platinum taxane chemotherapy after surgery at Keio University Hospital. The were respect to age diagnosis, clinical stage,...