A5003061329- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Colorectal Cancer Screening and Detection
- Potassium and Related Disorders
- Diverticular Disease and Complications
- Neuroendocrine Tumor Research Advances
- Inflammatory Bowel Disease
- Atrial Fibrillation Management and Outcomes
- COVID-19 and healthcare impacts
- Tumors and Oncological Cases
- Head and Neck Cancer Studies
- Infection Control and Ventilation
- Cancer Diagnosis and Treatment
- Medical Device Sterilization and Disinfection
- Oral and Craniofacial Lesions
- Genomic variations and chromosomal abnormalities
Toranomon Hospital
2017-2024
University Gastroenterology
2022
Tokyo Medical and Dental University
2020
Keio University
2019
RELX Group (Netherlands)
2018
Saitama Medical University
2011
Kure Kyosai Hospital
1992
Introduction: Gastroesophageal reflux disease (GERD) is diagnosed based on bothersome symptoms, such as heartburn, and the presence of mucosal breaks endoscopically. Treatments that suppress gastric acid, proton pump inhibitor (PPI) vonoprazan, are frequently administered. Several studies reported regarding safety side effects long-term PPI administration, including an association with polyps. We report a case maintained symptom resolution significantly shrank polyps by performing step-down...
: Asymptomatic esophageal eosinophilia (aEE), characterized by eosinophil infiltration in the esophagus without clinical symptoms, has been reported as a precursor of eosinophilic esophagitis (EoE). Nevertheless, no report exists on long-term course disease. Therefore, this study aimed to investigate aEE over 5 years, including symptomatic conversion rate and effect treatments.
Endoscopic submucosal dissection (ESD) is a promising procedure that enables en bloc resection of large superficial tumors in the upper gastrointestinal tract. On other hand, ESD colon and rectum technically difficult to perform because its anatomical features. At our institution, 137 consecutive colorectal larger than 20 mm diameter patients were treated by between April 2007 October 2010, 132 lesions successfully resected. The average time was 79.2 minutes, rate 89.1% (122/137). complete...
Background and study aims Delayed bleeding is one of the most serious adverse events gastric endoscopic submucosal dissection (ESD), especially in patients taking antithrombotic therapy. This aimed to evaluate utility safety a shielding method with autologous fibrin glue polyglycolic acid (PGA) sheets for undergoing ESD who are receiving Patients methods One hundred twenty-three were treated while therapy between December 2014 September 2017 enrolled this study. received classified into...
Patients with acromegaly are at increased risk of colorectal polyps. However, their cancer remains unclear. This study aimed to identify the histopathological features polyps in patients and compare that healthy controls.The participants were 178 who underwent Hardy's operation perioperative colonoscopy our hospital between April 2008 September 2016. For control group, we randomly selected 356 age- sex-matched during same period. The incidence, size, location, histology detected compared...
Objective According to consensus guidelines, eosinophilic esophagitis (EoE) is defined as a clinicopathological entity whose symptoms and histology must always be considered together. However, endoscopic findings typical of EoE are often seen in asymptomatic esophageal eosinophilia (aEE). We aimed clarify the features aEE. Methods retrospectively compared cases aEE those symptomatic EoE. Materials reviewed 146 patients who underwent upper gastrointestinal endoscopy were confirmed...
Superficial pharyngeal squamous cell carcinoma (PSCC) has received increasing attention as a therapeutic target in the GI field with recent innovations endoscopic submucosal dissection (ESD). However, there are currently no defined criteria for application of ESD to superficial PSCC. One problems encountered during follow-up after is cervical lymph node metastasis (LNM). Identifying clinicopathologic predictors LNM can help provide basis refinement strategies PSCC.The risk was evaluated 331...
Aim The number of patients with fatty liver disease (FLD) is increasing globally. Ethanol consumption in FLD known to be associated an increased risk hepatocellular carcinoma (HCC), but the effects alcohol on occurrence multiple HCCs remain unclear. We explored relationship between daily ethanol intake and HCC number. Methods This single‐center retrospective study enrolled 114 without viral or immune hepatitis undergoing first‐line treatment who had been diagnosed by abdominal...
Abstract Background Jackhammer esophagus (JE) is a hypercontractile esophageal motility disorder diagnosed using high-resolution manometry (HRM). We sought to determine the clinical presentation and therapeutic data of patients with JE in Japan. Methods The study included JE, through HRM performed for suspicious disorders. Demographics, esophagogastroduodenoscopy, radiology, therapy were collected from patient charts. Results Among 4,412 tests performed, 89 (61.6 ± 13.4 years; 64 males, 25...
In the post-Helicobacter pylori era, autoimmune gastritis (AIG) is attracting increasing attention as an origin of gastric cancer. Here, we performed clinicopathological examination cancer complicating AIG treated in our hospital.
Objective: Patient‐reported outcomes (PROs) are becoming pivotal in managing gastroesophageal reflux disease (GERD). Current Japanese guidelines for GERD recommend vonoprazan (VPZ) as a treatment option mild esophagitis (RE). However, it has been hypothesized that 4 weeks of VPZ 20 mg is not always necessary RE if the outcome based on patient symptoms. This study aimed at elucidating efficacy new tapering therapeutic strategy (step‐down therapy) using symptomatic PRO. Methods: multicenter...
Abstract Background and study aims Endoscopic submucosal dissection (ESD) is widely performed for superficial esophageal cancer, but stricture after extensive resection a major clinical problem. Using an ultrathin endoscope would enable endoscopists to approach lesions beyond the stricture. We evaluated feasibility of ESD. Methods To perform ESD with endoscope, we developed transparent hood knife. A total 24 ESDs were by two excised live porcine esophaguses. GIF-Q260 J Dual knife used in...
Abstract Background and study aims Infection control is essential when performing endoscopic procedures, especially during the COVID-19 pandemic. Therefore, we have developed a new shielding device called STEP for infection in upper gastrointestinal endoscopy. Patients methods consists of mask worn by patient drape that connected to covers endoscope. A suction tube attached prevents aerosols from spreading. The endoscopist operates endoscope through drape. Three endoscopists performed total...
Summary Treatment of esophageal cancer in the remnant esophagus after esophagectomy is highly invasive, therefore, early detection and minimally invasive treatment are considered necessary. Consequently, we aimed to clarify safety efficacy endoscopic submucosal dissection (ESD) for residual compared that a normal cervical esophagus. This study involved 47 patients with 59 cancers 92 107 who underwent ESD between January 2008 December 2023. Their clinicopathological findings long-term...
A 57-year-old man with a 10-year history of proton pump inhibitor (PPI) use presented multiple fundic gland polyps (FGPs) including one >20 mm, whitish, semi-pedunculated polyp. Black spots and cobblestone-like mucosa were also observed in the stomach upon endoscopy; therefore, lesion was considered to result from long-term PPI administration. Endoscopically, we diagnosed this polyp as neoplastic gastric phenotype rather than non-neoplastic lesion. Biopsy revealed an atypical...
<b><i>Introduction:</i></b> Patients with ulcerative colitis (UC) have an increased risk of colorectal cancer. Some studies recently investigated endoscopic resection UC-associated neoplasia (UCAN), but the indications for UCAN remain controversial. This study sought to clarify problems encountered in submucosal dissection (ESD) UCAN. <b><i>Methods:</i></b> Seventeen lesions 12 patients (UCAN group) and 913 epithelial 824 control without UC...
Objective Clipping is a common technique for managing colonic diverticular bleeding (CDB), despite the lack of published evidence regarding its effectiveness. We aimed to evaluate effectiveness clipping CDB in preventing early recurrent bleeding. Methods This dual-center retrospective study included 93 patients who underwent emergency hospitalization bloody stool, diagnosed with definitive CDB, and treated or conservative treatment. The primary outcome was A logistic regression analysis...
Introduction: Multiple Lugol-voiding lesions (LVLs) in the esophagus increase risk of synchronous and metachronous development esophageal squamous cell carcinoma (ESCC). Chemoradiotherapy (CRT) following endoscopic submucosal dissection (ESD) may reduce incidence ESCC, but few studies have investigated this. Therefore, we retrospectively examined effect CRT on ESCC multiple dysplasias visible as LVLs. Methods: This study reviewed 146 patients who underwent ESD were determined pathologically...
Characteristics of the chronotypes patients with gastrointestinal disease are unknown. We evaluated upper diseases Munich ChronoType Questionnaire (MCTQ). A total 2027 subjects from 29 institutions in Japan who had undergone esophagogastroduodenoscopy were asked to answer MCTQ. The subjects' divided into three groups (early, intermediate, and late chronotype) using sleep-corrected mid-point sleep on free days (MSFSC) values. According their endoscopic diagnosis abdominal symptoms, reflux...
Refractory reflux esophagitis (RRE), unresponsive to conventional proton-pump inhibitors (PPIs), is a complication in esophagectomy with gastric pull-up. Vonoprazan (VPZ), novel potassium-competitive acid blocker, has been available Japan since 2015. Here, we investigated the efficacy of VPZ on PPI-resistant RRE after pull-up.This was single-center retrospective study. We used revised Los Angeles (r-LA) classification based and modified evaluate abnormal forms mucosal breaks such as lateral...