Insulin action in skeletal muscle is enhanced by regular exercise. Whether insulin signaling human affected habitual exercise not well understood. Phosphatidylinositol 3-kinase (PI3-kinase) activation an important step the insulin-signaling pathway and appears to regulate glucose metabolism via GLUT-4 translocation muscle. To examine effects of on PI3-kinase activation, 2-h hyperinsulinemic (40 mU ⋅ m − 2 min 1 )-euglycemic (5.0 mM) clamps were performed eight healthy exercise-trained [24 ±...

This study had the following objectives: 1) to determine whether diabetic rats could increase muscle mass due a physiological manipulation (chronic resistance exercise), 2) exercise training status modifies effect of last bout on elevations in rates protein synthesis, and 3) chronic alters basal glycemia. Groups consisted or nondiabetic that performed progressive for 8 wk, acute exercise, remained sedentary. Arterial plasma insulin groups was reduced by about one-half ( P < 0.05) compared...

The temporal pattern for changes in rates of protein synthesis and glucose uptake after resistance exercise, especially relative to each other, is not known. Male Sprague-Dawley rats performed acute exercise ( n = 7) or remained sedentary 7 per group), the following were assessed vivo 1, 3, 6, 12 24 h later: synthesis, uptake, phosphatidylinositol 3-kinase (PI3-kinase) activity, p70 S6k activity. Rates mixed gastrocnemius muscle did increase until (e.g., at h, 138 ± 4 vs. exercised 178 6...

HERNANDEZ, J. M., T. MOCCIA, D. FLUCKEY, S. ULBRECHT, and P. A. FARRELL. Fluid snacks to help persons with type 1 diabetes avoid late onset postexercise hypoglycemia. Med. Sci. Sports Exerc., Vol. 32, No. 5, pp. 904–910, 2000. Purpose The present study assessed whether whole milk, skim or two commercially available sports drinks are effective in preventing hypoglycemia (LOPEH) mellitus. Methods Subjects ingested water, sport drink A(carbohydrate electrolytes), B (carbohydrate, fat, protein)...

This study determined whether rates of protein synthesis increase after acute resistance exercise in skeletal muscle from severely diabetic rats. Previous studies consistently show that postexercise are elevated nondiabetic and moderately Severely rats performed (n = 8) or remained sedentary 8). A group age-matched served as controls 9). Rates were measured 16 h exercise. Plasma glucose concentrations >500 mg/dl the (nmol phenylalanine incorporated. g muscle(-1). h(-1), means +/- SE) not...

Abstract Ozone (O 3 ) is a major component of smog and an inhaled toxicant to the lung. O rapidly reacts with airway epithelial cell membrane phospholipids generate lipid ozonation products (LOP). 1‐Hydroxy‐1‐hydroperoxynonane (HHP‐C9) important LOP, produced from 1‐palmitoyl‐2‐oleoyl‐sn‐glycerol‐3‐phosphatidylcholine. This at biologically relevant concentration (100 μM), increases activity phospholipase C, nuclear factors‐κB (NF‐κB), interleukin‐6 (NF‐IL‐6) expression inflammatory gene,...

Translational control of protein synthesis depends on numerous eukaryotic initiation factors (eIFs) and we have previously shown (Am. J. Physiol. Endocrinol. Metab. 276: E721-E727, 1999) that increases in one factor, eIF2B, are associated with rates after resistance exercise rats. In the present study investigated whether eIF4E family is also involved an anabolic response to exercise. Male Sprague-Dawley rats either remained sedentary (n = 6) or performed acute 6), were assessed vivo 16 h...

Eccentric exercise (ECC) causes muscle damage, insulin resistance, and increased pancreatic β-cell secretion in young individuals. However, the effects of age on response to glucose after ECC are unknown. Hyperglycemic clamps (180 min, 10.0 mM) were performed eight (age 22 ± 1 yr) older 66 2 healthy sedentary males without (CONT) 48 h ECC. ( P < 0.02) soreness ratings plasma creatine kinase concentrations both groups. Insulin C-peptide secretions similar between subjects during CONT...

Neural crest cells (NCC) migrate extensively in vertebrate embryos to populate diverse derivatives including ganglia of the peripheral nervous system. Little is known about molecular mechanisms that lead migrating trunk NCC settle at selected sites embryo, ceasing their migration and initiating differentiation programs. To identify candidate genes involved these processes, we profiled up-regulated purified post-migratory compared with migratory using a staged, macroarrayed cDNA library. A...

The skin is the most extensive organ in vertebrates, composed of two layers: epidermis and dermis. Sensory axons originating from dorsal root ganglia innervate mechanoreceptors Elasmobranchs, which appeared 380 million years ago, are characterized by rough dermal denticles. While we know about dermis elasmobranchs, do not much presence or abundance their skin. Using classic histological hematoxylin eosin method, examined skins hatchling embryos adults Batoidea (skates rays) Selachimorpha...

Objective: To assess the association between variability of both heart rate (HR) and systolic blood pressure (SBP) with left ventricular hypertrophy (LVH) cardiovascular risk (CR) in hypertensive patients. Design method: We included consecutive patients who underwent 24-hr ambulatory monitoring (ABPM) our outpatient clinic. Short-term SBP (SBPV) was calculated as average real (ARV). HR (HRV) determined standard deviation (SD-HR), well by ARV. LVH evaluated electrocardiographic criteria...

Objective: To assess the relationship between parathyroid hormone (PTH) serum levels and both blood pressure variability according to 24-hour ambulatory monitoring (ABPM) target organ damage (TOD). Design method: We compared demographic characteristics, ABPM parameters markers of TOD PTH in a cohort hypertensive patients referred our outpatient clinic. A cut-off point > 70 ng/ml defined elevated levels. Blood was calculated as average real (ARV). T- Student or chi-square tests were used...

Suarez Ortega, S.; Hernandez Aguiar, Y.; Arencibia Borrego, J; Sanchez Hernandez, J. M.; Rodriguez Perez, C.; Betancor Leon, P. Author Information

Rationale: Standard rodent diets mostly contain n6 fatty acids (n6), which are proinflammatory and may contribute to perpetuate the experimental colitis in these animals.We previously found that dietary MCT downregulate some inflammatory mediators rats.We aimed assess 1) effect of replacing 50% fat by on course IL10(-/-) mice, 2) molecular/cellular mechanisms involved.Methods: housed pathogen-free environment, were fed with 18% energy as fat, 100% sunflower oil (n6; n=12) or oil/50% coconut...

Objective: To assess the association between serum parathyroid hormone (PTH) or vitamin D levels with blood pressure, aldosterone-to-renin ratio, and target organ damage in a series of hypertensive patients. Design method: Observational cross-sectional study patients who undergone 24-hour ambulatory pressure monitoring (24-h ABPM), whom plasma aldosterone, PTH 25-OH were available. Blood (BP) was measured by ABPM. BP assessed as average real variability. Renin-angiotensin-aldosterone axis...

1302 The purpose of this study was to determine whether muscle hypertrophy occurs in diabetic rats response resistance exercise. Male Sprague Dawely performed exercise by repeated standing on the hindlimbs with weighted backpacks. Diabetic(partial pancreatectomy) or nondiabetic progressive for 8 weeks remained sedentary (sed). Arterial plasma insulin groups were reduced about half (p<0.05) when compared groups. Soleus(sol) and gastrocnemius/plantaris (gast/plant) complex wet weights lower...

136 Eccentric exercise results in delayed muscle soreness, damage, insulin resistance, and increased secretion young individuals. The purpose of this investigation was to determine if older subjects differ from subjects, the pancreatic β-cell response glucose following eccentric exercise. Hyperglycemic clamps (180 min, 10.0 mM) were performed on 8 (age, 22 ± 1 yrs; body mass index, BMI, 23.4 1.9 kg·m-2.; waist-to-hip ratio, WHR, 0.83 0.02) 66 2; 25.5 1.2; 0.91 0.01) sedentary healthy men...