A5103204204- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal Regulation and Hypertension
- NF-κB Signaling Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory mediators and NSAID effects
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Neonatal and Maternal Infections
- Endometrial and Cervical Cancer Treatments
- Sepsis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Cardiovascular Disease and Adiposity
- Immune Cell Function and Interaction
- IgG4-Related and Inflammatory Diseases
- Neurofibromatosis and Schwannoma Cases
- Ocular Oncology and Treatments
- Coronary Artery Anomalies
- Herbal Medicine Research Studies
- Teratomas and Epidermoid Cysts
- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Reproductive tract infections research
- Phosphodiesterase function and regulation
Suzhou Municipal Hospital
2004-2025
Nanjing Medical University
2013-2025
Ningxia Medical University
2025
Beijing University of Chinese Medicine
2024
The University of Texas MD Anderson Cancer Center
2024
Jiangsu Province Hospital
2014-2023
Beihang University
2023
People's Liberation Army 411 Hospital
2021
First Affiliated Hospital Zhejiang University
2019-2020
The People's Hospital of Guangxi Zhuang Autonomous Region
2019
Diabetes has been identified to be a risk factor for Alzheimer's disease (AD). Vildagliptin, novel oral hypoglycemic agent, demonstrated exert protective effects on the pancreas and cardiovascular system. The present study examined potential of vildagliptin neurons in an AD rat model. Treatment with improved memory deficits decreased neuronal apoptosis hippocampus. expression levels B cell lymphoma 2 (Bcl‑2) were increased, caspase‑3, Bcl‑2 associated X protein AD‑associated proteins...
Immune evasion is not only critical for tumor initiation and progression, but also determines the efficacy of immunotherapies. Through iterative in vivo CRISPR screens with seven syngeneic models, we identified core context-dependent immune pathways across cancer types. This valuable high-confidence dataset available further understanding intrinsic immunomodulators, which may lead to discovery effective anticancer therapeutic targets. With a focus on triple-negative breast (TNBC), found that...
Frailty and poor sleep are both risk factors for delirium, but their joint interactive associations with incident delirium unknown. The study aimed to examine the of frailty status quality delirium. A total 346,846 participants from UK Biobank without dementia, or cognitive impairment at baseline were included. Incident cases identified through International Classification Diseases, Tenth Revision codes. modified-version Fried phenotype was utilized evaluate status. score comprising five...
Physiological levels of glucocorticoids (GCs) are required for proper metabolic control, and excessive GC action has been linked to a variety pandemic diseases. MicroRNA (miRNA)-19b plays critical role in the pathogenesis GC-induced This study explored potential miRNA-based therapeutics targeting adipose tissue. Our results showed that overexpressed miR-19b stromal vascular fraction (SVF) cells derived from subcutaneous tissue had same effects as dexamethasone (DEX) treatment on inhibition...
Given the rising prevalence of central obesity and discovery that beige cells appear within white adipose tissue, strategies to enhance these energy-expending adipocytes or "browning" depots have become therapeutic interest combat its associated disorders. This study focused on, role microRNA (miRNA)-27b-3p in human visceral tissue (VAT) browning. Expression miR-27b-3p UCP1 VAT serum humans was measured. MiR-27b-3p overexpressed suppressed stromal fraction analyze potential miR-27b-3p....
Obesity, especially central obesity, is a strong risk factor for developing type 2 diabetes (T2D). However, the mechanism underlying progression from obesity to T2D remains unknown. Therefore, we analyzed gut microbial profiles of obese individuals with or without Chinese population. Here reported both compositional and gene functional alterations during T2D. Several opportunistic pathogens were enriched in patients. We also characterized thousands genes involved sugar amino acid metabolism...
Objectives This study aimed to compare the diagnostic efficacy of contrast‐enhanced ultrasound (CEUS), including SonoVue (SV; sulfur hexafluoride; Bracco SpA, Milan, Italy) and Sonazoid (SZ; perflubutane; GE Healthcare, Oslo, Norway), explore differences between them in characterization CEUS features focal nodular hyperplasia (FNH) smaller than 3 cm. Methods retrospective included 31 lesions cm diagnosed as FNH by April 2019 November 2019. Nine patients underwent SZ examinations, 22 SV...
Background and Objective Porphyromonas gingivalis (Pg) lipopolysaccharide is associated with the immune response atherosclerosis. This study aimed to evaluate effects of micro‐amounts Pg‐lipopolysaccharide on rabbit inflammatory development Material Methods Twenty‐four New Zealand white rabbits were randomly divided into four groups ( n = 6). Group A was fed a regular diet normal saline. B supplied high‐fat C treated Pg‐lipopolysaccharide. D given After 14 wk, killed determine changes in...
The role of glucocorticoids as anti-inflammatory and immune-stimulatory drugs has been widely reported. However, the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which catalyzes conversion inactive cortisone into active cortisol, in inflammation remains unclear. This study aimed to examine mechanism actions 11β-HSD1 lipopolysaccharide (LPS)-induced THP-1 cells.The gene expression pro-inflammatory cytokines was detected via RT-PCR. protein IL-1β cell supernatants ELISA. Oxidative...
The present study aimed to investigate the effects of bone marrow mesenchymal stem cells (MSCs) on cardiac function and immune system mice with endotoxemia. were divided into following groups: Control group, endotoxemia lipopolysaccharide (LPS) treatment LPS MSC group (LPS + group) group. Following LPS, was examined at after 2, 6 24 h, day 7. An enzyme‑linked immunofluorescent assay used analyze serum levels cytokines in myocardium, western blotting any changes signaling proteins associated...
Cardiomyocyte apoptosis is thought to play an important role in sepsis-induced cardiodepression. Previous studies mainly focused on the of exogenous TNF-α cardiac damage, however, endogenous rarely known. Therefore, we hypothesized that also contributed cardiomyocyte apoptosis. Primary neonatal rat cardiomyocytes were time- and dose-dependently stimulated with BLP TNF-α. In separate experiments, cells treated antagonist IL-10, respectively, determine effects IL-10 BLP-induced After...
Sepsis is a severe illness in which the bloodstream overwhelmed by bacteria. Despite effective antibiotic treatment, mortality of septic shock remains high. In this study, we examined potential usage paeoniflorin, anti-inflammatory component for treatment sepsis. We established an inflammatory cell line stimulating human THP-1 with bacterial lipoprotein (BLP), resulted activation nuclear factor κB (NF-κB) p65 dependent-signal pathway, and consequence, increase tumor necrosis α (TNF-α)...
To analyze the imaging features of coronary artery-to-pulmonary artery fistula (CPAF) on computed tomography angiography (CCTA).This was a retrospective study 3,975 patients who underwent 320 row detector CCTA examinations in our hospital from May 2015 to July 2020. A total 22 diagnosed with CPAF were reviewed for characteristics, including origin, number, blood volume, opening size, and course vessels, drainage site, fistula. All cases analyzed presence atherosclerotic plaque that deficient...
To study signal intensity (SI) of the fetal liver by MRI in-phase and out-of-phase over gestational age (GA).A total 91 pregnant women from 19 to 38 weeks were imaged using MRI. Liver-to-spleen SI ratios right left lobes on measured, calculated, compared with each other. Curves liver-to-spleen ratio lobe plotted GA.Liver-to-spleen was different that (t = 3.95; p < 0.001). A statistically significant difference also found for 3.69; showed changes against is between lobe, which probably...
To evaluate the application of contrast-enhanced ultrasonography (CEUS) in diagnosis inflammatory pseudotumor liver (IPL).The untrasonography was performed 32 cases IPL and results were retrospectively analyzed.Among total cases, 21 had absent contrast enhancement (type I); 6 rimlike or stringlike during arterial phase presented hypoechoic lesions late II); 2 diffuse homogeneous early phase,persisting hyperechoic III); 3 phases washed out more quickly than parenchymal IV).The perfusion...
Sepsis-induced myocardial dysfunction is primarily accompanied by severe sepsis, which associated with high morbidity and mortality. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), encoded Hsd11b1, a reductase that can convert inactive cortisone into metabolically active cortisol, but the role of 11β-HSD1 in sepsis-induced remains poorly understood. The current study aimed to investigate effects on lipopolysaccharide (LPS)-induced mouse model, LPS (10 mg/kg) was administered wild-type...