A5049223582- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Lung Cancer Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- PI3K/AKT/mTOR signaling in cancer
- Gastric Cancer Management and Outcomes
- Neonatal Respiratory Health Research
- Long-Term Effects of COVID-19
- Tissue Engineering and Regenerative Medicine
- Congenital Diaphragmatic Hernia Studies
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antifungal resistance and susceptibility
- Brain Metastases and Treatment
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- High Altitude and Hypoxia
- Tracheal and airway disorders
- Phagocytosis and Immune Regulation
Tokyo Dental College Ichikawa General Hospital
2018-2025
National Cancer Center Hospital East
2025
Keio University
2013-2021
Jikei University School of Medicine
2015
Alectinib is a highly selective ALK inhibitor and shows promising efficacy in non-small cell lung cancers (NSCLC) harboring the EML4-ALK gene rearrangement. The precise mechanism of acquired resistance to alectinib not well defined. purpose this study was clarify ALK-translocated cancer cells. We established alectinib-resistant cells (H3122-AR) from H3122 NSCLC line, rearrangement, by long-term exposure alectinib. H3122-AR evaluated phospho-receptor tyrosine kinase (phospho-RTK) array...
The niche surrounding stem cells regulate their fate during homeostasis and after injury or infection. 3D organoid assay has been widely used to study behavior based on its capacity evaluate self-renewal, differentiation the effect of various medium supplements, drugs co-culture with supportive cells. We established an both lung trachea in vitro. characterized proliferation spectrum at baseline then evaluated co-culturing fibroblasts endothelial and/or treating several biologically relevant...
The impact of the coronavirus disease 2019 (COVID-19) pandemic on cancer care remains a concern. We aimed to evaluate access diagnosis and treatment for lung during pandemic.Times (days) from symptom onset or referral visit (pre-visit time), (pre-diagnosis (pre-treatment time) were compared with times pre-pandemic period.The number patients diagnosed was 82 75 periods, respectively. percentage advanced-stage higher (65.9% vs. 46.7%), treated surgery lower medication (24.4% 41.3% 57.3% 40.0%,...
Introduction: Brain metastasis is a serious complication in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Brainstem metastases are particularly challenging to treat because of the high risks associated with surgery and stereotactic radiosurgery. Case Presentation: We present case 56-year-old woman HER2-positive cancer who developed multiple brain metastases, including large medullary lesion, 9 months after confirming pathological complete response standard...
Fibroblast growth factor 9 (FGF9) is essential for lung development and highly expressed in a subset of human adenocarcinomas. We recently described mouse model which FGF9 expression the epithelium caused proliferation airway at terminal bronchioles led to rapid adenocarcinoma. Here, we used this characterize effects prolonged induction on proximal distal epithelia, examined propagation potential FGF9-induced tumours. showed that over-expression resulted adenocarcinomas arising from both...
Abstract Background Immune checkpoint inhibitors (ICIs) are the standard treatment for non-small cell lung cancer. The unique adverse events that can arise after with ICIs known as immune-related (irAE). As number of cases under increases, new types characteristics irAE have emerged. This case report suggests IgG4-related pleural disease could occur an irAE. Case presentation A 64-year-old man was diagnosed pulmonary adenocarcinoma stage IIIB. Following concurrent chemoradiotherapy,...
Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression ALDHs is marker for stem cells many organs including the lungs. A common polymorphism ALDH2 gene (ALDH2*2) results inactivation enzyme and associated with alcohol flushing syndrome increased risk cardiovascular Alzheimer's diseases some cancers. The effect this on lung its has not been thoroughly examined. We examined association between ALDH2*2 allele function parameters population healthy...
Abscopal effect is the out-of-field response to localized irradiation therapy that results in systemic antitumorigenic effects such as regression of a tumor distant from target site. A 76-year-old woman was diagnosed with pulmonary adenocarcinoma (cT1bN0M0 stage IA), and right upper lobectomy performed November 2015. The pathological pT1bN2M0 IIIA. Genomic analysis revealed an EGFR mutation. Immunohistochemical programmed death-ligand 1 proportion score < 1%. patient under watchful...
Lung cancer is the most lethal in world. Intensive research ongoing worldwide to identify new therapies for lung cancer. Several mouse models of are being used study mechanism development and experiment with various therapeutic strategies. However, absence a real-time technique tumor nodules mice lungs monitor changes their size response experimental interventions hampers ability obtain an accurate description course disease its timely treatments. In this study, method using micro-computed...
Bronchiectasis is a chronic respiratory condition characterized by irreversible bronchial dilation, often caused infection or inflammation. It can be associated with primary ciliary dyskinesia (PCD), hereditary disorder affecting cilia function in various organs and flagella. PCD's genetic heterogeneity leads to varying disease severity. PCD may more prevalent Asia, but its diagnosis delayed Japan. This study reviewed case of retinitis pigmentosa (RP) the relevant literature. The patient had...
The aim of this study was to assess the efficacy and safety erlotinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), as second‑ or third‑line treatment for elderly Japanese patients with non‑small‑cell lung cancer (NSCLC). eligible phase II trial were aged ≥70 years, had stage III/IV recurrent NSCLC, previously received 1 2 chemotherapy regimens that did not include EGFR‑TKIs. erlotinib at a dose 150 mg/day. primary endpoint overall response rate (ORR),...
A 69-year-old man with post-operative recurrence of lung adenocarcinoma was treated multiple chemotherapies, including epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors. second biopsy revealed an EGFR T790M mutation. As 10th-line chemotherapy, osimertinib initiated. After 24 weeks, chest computed tomography (CT) asymptomatic ground-glass opacities in both lobes. four weeks discontinuation, imaging rapid cancer progression. Osimertinib resumed. 11 CT decreased nodules no...
Abstract ABT‐263 (Navitoclax) is a BH3‐mimetic drugs targeting anti‐apoptotic B‐cell lymphoma‐2 (BCL‐2) family proteins, including BCL‐2, BCL‐xL, and BCL‐w, thereby inducing apoptosis. In small‐cell lung cancer (SCLC) cells, the response to associated with expression of myeloid cell leukemia‐1 (MCL‐1) protein, however efficacy in non‐small‐cell (NSCLC) has not been thoroughly evaluated. There are currently no established biomarkers for predicting treatment NSCLC. We screened panel different...
Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)-induced interstitial lung disease (ILD) may be a life-threatening condition that develop during treatment of cancer patients harboring EGFR mutations. We herein present the case 41-year-old female patient diagnosed with adenocarcinoma an mutation (exon 19 deletion). The was treated gefitinib followed by erlotinib and developed ILD induced both EGFR-TKIs; furthermore, acquired resistance to EGFR-TKI treatment. A repeat...
A 70-year-old woman with rheumatoid arthritis undergoing methotrexate (MTX) treatment presented dyspnea and a subfever. Computed tomography (CT) revealed diffuse minimal ground-glass appearance in both lungs splenomegaly. The gallium scintigram showed diffuse, mild uptake the spleen. lung biopsy specimen presence of CD20-positive atypical lymphocytes small pulmonary vessels. patient was diagnosed intravascular large B-cell lymphoma (IVLBCL) exhibited spontaneous regression after MTX...
Abstract Rationale: ABT-263 (Navitoclax) is one of the BH3 mimetics targeting anti-apoptotic B-cell lymphoma-2 (Bcl-2) family proteins such as Bcl-2, Bcl-XL, and Bcl-w, thereby inducing apoptosis. It has been reported that response to associated with expressions myeloid cell leukemia-1 (Mcl-1), an protein. Given its effectiveness a single agent in preclinical studies, currently being evaluated clinical trials for small lung cancer (SCLC) leukemia. However, efficacy non-small (NSCLC) not...
Lung cancer is the most lethal in world. Intensive research ongoing worldwide to identify new therapies for lung cancer. Several mouse models of are being used study mechanism development and experiment with various therapeutic strategies. However, absence a real-time technique tumor nodules mice lungs monitor changes their size response experimental interventions hampers ability obtain an accurate description course disease its timely treatments. In this study, method using micro-computed...
Metastatic peritoneal carcinomatosis (MPC) is not common in patients with non-small cell lung cancer (NSCLC), and the clinical characteristics treatment outcomes are still unclear.We recruited 46 NSCLC MPC at Keio University affiliated hospitals (Keio Lung Oncology Group) between January 2011 December 2017, then retrospectively investigated their impact of interventions on survival.The profile histological subtype was predominantly adenocarcinoma 15 harbored driver oncogenes. Univariate...
Both disseminated cryptococcal infection and tuberculosis occur in hosts with impaired cell-mediated immunity, but there have been few reports about the concurrent infections patients without human immunodeficiency virus infection. A 64-year-old man, who had taking corticosteroids for interstitial pneumonia, was diagnosed While patient receiving anticryptococcal therapy, pulmonary also emerged. The developed acute exacerbation of pneumonia passed away. Based on patient’s clinical course,...
A 19-year-old woman was referred to our hospital because of a persistent fever and cough that lasted for over week. Influenza B virus infection diagnosed using the rapid test kit. Initially, patient with influenza associated lobar pneumonia treated an anti-influenza drug sulbactam/ampicillin. The patient’s persisted, her respiratory condition worsened. On day 5, computed tomography (CT) scan revealed extension consolidation areas in left lung new opacities right lung. antibiotic treatment...
背景.肺原発多形癌の臨床像とその治療法を手術症例で検討する.対象・方法.2016年1月から2021年6月の間に当院で手術を施行した肺原発多形癌7例の臨床像を後方視的に検討した.結果.対象7例は男性5例と女性2例で,年齢は64~81歳であった.臨床病期はIA期3例,IB期1例,IIA期1例,IIB期1例,IIIA期1例で,術式は肺全摘1例,肺葉切除5例,区域切除1例であった.術後無再発の2例は31ヶ月,28ヶ月間生存中であるが,5例に術後再発が認められ,うち2例は術後早期に癌死した.他3例には副腎転移が見られ,両側副腎転移の1例には化学療法と免疫チェックポイント阻害薬を投与し,術後32ヶ月も無再発生存中である.片側副腎転移の2例には副腎摘除術を施行,1例には化学療法を追加し,66ヶ月と52ヶ月の間無再発生存中である.結語.肺原発多形癌術後の単発の片側副腎転移症例は転移巣切除や免疫チェックポイント阻害薬投与により予後良好であった.一部の症例では転移巣を含む積極的な外科的治療の介入が長期生存の一助となり得る可能性が示唆された.