A5101493928- Mitochondrial Function and Pathology
- Urinary Bladder and Prostate Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Pelvic floor disorders treatments
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Urological Disorders and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
- Iron and Steelmaking Processes
- Photosynthetic Processes and Mechanisms
- Pancreatic function and diabetes
- Nonlinear Photonic Systems
- Pituitary Gland Disorders and Treatments
- Renal and related cancers
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ferroptosis and cancer prognosis
- Spondyloarthritis Studies and Treatments
- Pulmonary Hypertension Research and Treatments
Nanjing Medical University
2024-2025
Shandong First Medical University
2022-2024
Shandong Provincial Hospital
2019-2024
Shanghai Pudong New Area Gongli Hospital
2023-2024
Zhongda Hospital Southeast University
2024
Second Military Medical University
2023-2024
National Clinical Research Center for Digestive Diseases
2024
Capital Medical University
2013-2024
Beijing Friendship Hospital
2024
Fourth Hospital of Hebei Medical University
2024
The changes of inflammation and metabolism are two features in nonalcoholic steatohepatitis (NASH). However, how they interact to regulate NASH progression remains largely unknown. Our works have demonstrated the importance solute carrier family 7 member 11 (SLC7A11) metabolism. Nevertheless, whether SLC7A11 regulates through mediating is unclear. In this study, we found that expression was increased liver samples from patients with NASH. Upregulated level also detected murine models....
Chronic inflammation is critical for the initiation and progression of type 2 diabetes mellitus via causing both insulin resistance pancreatic β cell dysfunction. miR-155, highly expressed in macrophages, a master regulator chronic inflammation. Here we show that blocking macrophage-derived exosomal miR-155 (MDE-miR-155) mitigates resistances glucose intolerances high-fat-diet (HFD) feeding type-2 diabetic db/db mice. Lentivirus-based sponge decreases level pancreas improves...
Abstract Background Mitochondria play central roles in metabolic diseases including nonalcoholic steatohepatitis (NASH). However, how mitochondria regulate NASH progression remains largely unknown. Our previous findings demonstrate that mitochondrial general control of amino acid synthesis 5 like 1 (GCN5L1) is associated with metabolism. Nevertheless, the GCN5L1 are unclear. Aims and methods The expression was detected fatty livers patients animals. Hepatocyte‐specific deficiency or...
Aging is the risk factor for chronic pancreatitis and severity determinant its acute attack, yet underlying cause unclear. Here, we demonstrate that senescent β-cells of endocrine pancreas decide onset pancreatitis. During physiological aging, increase expression miR-503-322 which secreted as small extracellular vesicles to enter exocrine acinar cells, driving a causal reversible role on aging-associated Mechanistically, targets MKNK1 inhibit acinar-cell secretion leading autodigestion...
Abstract Our study aims to investigate the roles that microRNA-214 (miR-214) plays in epithelial mesenchymal transition (EMT) process and development of interstitial cystitis (IC) postmenopausal women by targeting Mitofusin 2 (Mfn2). IC bladder tissues adjacent normal were collected from women. Immunohistochemistry (IHC) staining was conducted. The target relationship between miR-214 Mfn2 determined a dual luciferase reporter gene assay. Adipose-derived stem cells (ADMSCs) extracted rats...
No AccessJournal of UrologyAdult Urology1 Jun 2017Efficacy Electrical Pudendal Nerve Stimulation versus Transvaginal in Treating Female Idiopathic Urgency Urinary Incontinence Siyou Wang, Jianwei Lv, Xiaoming Feng, and Tingting Lv WangSiyou Wang Clinical Research Section, Shanghai Institute Acupuncture Meridian, Shanghai, China University Traditional Chinese Medicine Yueyang Hospital Western Medicine, , LvJianwei Department Urology, Jiaotong School Renji Hospital, FengXiaoming Feng...
The toxicities of conventional chemotherapeutic agents to normal cells restrict their dosage and clinical efficacy in acute leukemia; therefore, it is important develop novel chemotherapeutics, including natural products, which selectively target cancer‑specific pathways. present study aimed explore the effect chemopreventive agent asiatic acid (AA) on proliferation apoptotic rate leukemia cell line HL‑60 investigated mechanisms underlying its anti‑tumor activity. AA was evaluated using MTT...
Diabetic kidney disease (DKD) is the major cause of end‐stage renal (ESRD). In past few decades, there has been a large amount evidence to highlight pivotal role oxidative stress in development and progression DKD. However, detailed molecular mechanisms are not fully elucidated. A new sight established that mitochondrial acetyltransferase GCN5L1 participates cellular redox homeostasis maintenance Firstly, we found expression significantly elevated both human mouse tissues with DKD...
Although pituitary adenomas are histologically benign, they often accompanied by multiple complications, such as cardiovascular disease and metabolic dysfunction. In the present study, we repositioned Food Drug Administration -approved immune regulator tamoxifen to target STAT6 based on genomics analysis of PAs. Tamoxifen inhibited proliferation GH3 AtT-20 cells with respective IC50 values 9.15 7.52 μM increased their apoptotic rates in a dose-dependent manner. At molecular level,...
Mitochondrial DNA (mtDNA) encodes thirteen core components of OXPHOS complexes, and its steady expression is crucial for cellular energy homeostasis. However, the regulation mtDNA machinery, along with sensing mechanism to energetic stresses, not fully understood. Here, we identified SQSTM1/p62 as an important regulator which could effectively induce effects were mediated by p38-dependent upregulation mitochondrial ribosomal protein L12 (MRPL12) in renal tubular epithelial cells (TECs), a...
We sought to elucidate the effects of different concentrations dietary selenium on calcium ion release, MLCK levels, and muscle contraction in uterine smooth rats. The (Se) content blood tissues was detected by fluorescence spectrophotometry. Ca(2+) measured atomic absorption spectroscopy. Calmodulin (CaM) RNA protein levels were analyzed quantitative real-time polymerase chain reaction Western blot, respectively. Dietary Se intake increased concentration tissues. addition also promoted CaM...
Abstract Background Mitochondrial dysfunction is an important pathogenic event in acute kidney injury (AKI). GCN5L1 a specific acetyltransferase mitochondria, which regulates glucose and fatty acid metabolism. However, the role of mitochondrial pathogenesis ischemic AKI are not fully understood. Methods The protein level was detected by western blot assay. Acetylated proteomics used to explore acetylated TFAM. Duolink proximity ligation assay co-immunoprecipitation were detect interaction...
AtDjB1 is a mitochondria-located J-protein in Arabidopsis thaliana It involved the regulation of plant growth and development; however, exact mechanisms remain to be determined. We performed comparison analyses phenotypes, auxin signalling, redox status, mitochondrial structure function using wild-type plants, mutants, rescued mutants by or YUCCA2 (an synthesis gene), overexpression plants. (atj1-1 atj1-4) exhibited inhibition development reductions level IAA expression YUCCA genes compared...
The clinicopathological features and long-term outcomes of patients with vanishing bile duct syndrome (VBDS) have yet to be elucidated. study aims investigate these identify factors associated poor prognosis.This multicenter retrospective recruited liver biopsy-proven VBDS who were followed up at five hospitals in northern China from January 2003 April 2022. Clinical pathological data time biopsy reviewed. including cirrhosis, decompensation events, transplantation (LT), liver-related death...
Arabidopsis mitochondrial-localized heat shock protein 70-1 (mtHSC70-1) modulates vegetative growth by assisting mitochondrial complex IV assembly and maintaining reactive oxygen species (ROS) homeostasis. In addition, mtHSC70-1 affects embryo development, this effect is mediated auxin. However, whether regulates through auxin knowledge of the link between ROS homeostasis distribution remain unclear. Here, we found that knockout seedlings (mthsc70-1a) displayed shortened roots, decreased...
<title>Abstract</title> Aging is the major risk factor for chronic pancreatitis and severity determinant its acute attack, yet underlying cause unclear. Here, we demonstrate that senescent β-cells of endocrine pancreas decide onset pancreatitis. During physiological aging, increase expression miR-503-322 which secreted as nano-vesicles to enter exocrine acinar cells, driving a causal reversible role on aging-associated Mechanistically, represses MKNK1 inhibit acinar-cell secretion...
Abstract Objective Smoke inhalation lung injury (SILI) is a common complication in fires and wars, characterized by acute onset severe condition. Pirfenidone (PFD), new small‐molecule drug, has been shown to improve function inhibit pulmonary fibrosis inflammation. This study aimed elucidate the effect underlying mechanism of PFD on SILI rats. Materials Methods rats were constructed using homemade smoking device, which was then treated with PFD. The blood collected from abdominal aorta,...
Primary biliary cholangitis (PBC) with early cholestasis and extensive bile duct loss but no significant fibrosis or cirrhosis is rare underrecognized. We aimed to clarify the clinicopathology features prognosis of these variants patients early-stage PBC ductopenia. From January 2009 2023, we retrospectively collected laboratory pathologic data recorded their liver-related events a median follow-up 4.5 years. Finally, total 141 in stage were included divided into 2 groups: one ductopenia (n...
Introduction: Hepatocellular carcinoma (HCC), which is closely associated with chronicinflammation, the most common liver cancer and primarily involves dysregulated immune responses in precancerous microenvironment. Currently, studies have been limited to HCC incidence. However, immunopathogenic mechanisms underlying lesions remain unknown. Methods: We obtained single-cell sequencing data (GSE136103) from two nonalcoholic fatty disease (NAFLD) cirrhosis samples five healthy samples. Using...