A5025329621- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Mosquito-borne diseases and control
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Malaria Research and Control
- Vector-borne infectious diseases
- Cancer Immunotherapy and Biomarkers
- Parasites and Host Interactions
- Yersinia bacterium, plague, ectoparasites research
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- Hemoglobinopathies and Related Disorders
- Diverse Scientific Research Studies
- Biological Research and Disease Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Genetics, Bioinformatics, and Biomedical Research
- Genetic factors in colorectal cancer
- Virus-based gene therapy research
University of Michigan
2019-2025
Michigan Medicine
2019-2024
Thermo Fisher Scientific (United States)
2023
Indiana University – Purdue University Indianapolis
2018-2021
Indiana University School of Medicine
2018-2021
Ann Arbor Center for Independent Living
2020
Seattle University
2020
A. Alfred Taubman Health Care Center
2020
Abstract Strategies that interfere with the binding of receptor programmed cell death protein-1 (PD-1) to ligand-1 (PD-L1) have shown marked efficacy against many advanced cancers, including those are negative for PD-L1. Precisely why patients PD-L1 tumors respond PD-1/PD-L1 checkpoint inhibition remains unclear. Here, we show platelet-derived regulates growth and interference platelet cancer cells promotes T cell-induced cytotoxicity. These results suggest successful outcomes based...
Abstract Localized prostate cancer is frequently composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing clones that may drive the biological trajectory disease. Previous large-scale sequencing efforts have focused on evolutionary process in metastatic cancer, revealing a potential clonal progression castration resistance. However, origin synchronous lymph node (LN) metastases...
Among the severe malaria syndromes, malarial anemia (SMA) is most common, whereas cerebral (CM) lethal. However, mechanisms that lead to CM and SMA are unclear.We compared transcriptomic profiles of whole blood obtained from Ugandan children with acute (n = 17) or community without Plasmodium falciparum infection 12) determined relationships among gene expression, hematological indices, relevant plasma biomarkers.Both demonstrated predominantly upregulated enrichment dendritic cell...
569 Background: Gene expression and mutation analyses in metastatic clear cell renal carcinoma (ccRCCs) have attempted to identify tumors that differentially respond tyrosine kinase inhibitors (TKIs) immunotherapy (IO) – broadly an angiogenic immunogenic clade. However, ccRCC is genomically heterogeneous sequencing a single-region of primary tumor does not necessarily represent the clone. We re-analyzed biomarker results Phase III IMmotion151 trial, stratifying patients into primary-derived...
578 Background: Our group previously developed and validated a 15-gene prognostic signature (15G score) in localized clear cell renal carcinoma (ccRCC). Giving its ability to differentiate aggressive indolent disease the setting, we sought apply 15G score patients with metastatic ccRCC evaluate score’s performance across different treatments. Methods: We analyzed 2,121 from four major trial datasets: IMmotion 150 (IMM150), Immotion 151 (IMM151), Javelin Renal 101 (JR101), Checkmate 009, 010,...
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires type IVB secretion system (T4BSS), which translocates bacterial effector proteins across vacuole membrane into cytoplasm, where they manipulate a variety processes.
PURPOSE Multiparametric magnetic resonance imaging (mpMRI) is used widely for prostate cancer (PCa) evaluation. Approximately 35% of aggressive tumors, however, are not visible on mpMRI. We sought to identify the molecular alterations associated with mpMRI-invisible tumors and determine whether mpMRI visibility PCa prognosis. METHODS Discovery validation cohorts included patients who underwent before radical prostatectomy were found harbor both mpMRI-visible (Prostate Imaging Reporting Data...
There is a need to optimize the treatment of clear cell renal carcinoma (ccRCC) patients at high recurrence risk after nephrectomy. We sought elucidate tumor immune microenvironment (TIME) localized ccRCC and understand prognostic predictive characteristics certain features. The discovery cohort was clinically in TCGA-Kidney Renal Clear Cell Carcinoma (KIRC) project (n = 382). identified an M0 macrophage-enriched cluster 25) TCGA-KIRC cohort. This cluster’s median progression-free survival...
Abstract Background Further reductions in malaria incidence as more countries approach elimination require the identification and treatment of asymptomatic individuals who carry mosquito-infective Plasmodium gametocytes that are responsible for furthering transmission. Assessing relationship between total parasitaemia gametocytaemia field surveys can provide insight to whether detection low-density, falciparum infections with sensitive molecular methods adequately detect majority infected...
You have accessJournal of UrologyKidney Cancer: Basic Research & Pathophysiology II (PD51)1 May 2024PD51-02 INTEGRATIVE MOLECULAR PROFILING OF RENAL CELL CARCINOMA NATIVE TISSUE AND PATIENT DERIVED ORGANOIDS IDENTIFIES PREDICTIVE MARKERS DRUG RESPONSE Daniel A. Triner, Trinh Pham, Srinivas Nallandhighal, Brittney Cotta, Zayne Knuth, Fengyun Sun, Aaron Udager, Saravana Dhanasekaran, Nathan Merrill, and Simpa S. Salam TrinerDaniel Triner , PhamTrinh Pham NallandhighalSrinivas Nallandhighal...
The substantial biological heterogeneity of metastatic prostate cancer has hindered the development personalized therapeutic approaches. Therefore, it is difficult to predict course hormone-sensitive (mHSPC), with some men remaining on first-line androgen deprivation therapy (ADT) for several years while others progress more rapidly. Improving our ability risk-stratify patients would allow optimization systemic therapies and support stratified prospective clinical trials focused likely have...
Abstract Prostate cancer (PCa) is the second most common and constitutes about 14.7% of total cases. PCa highly prevalent more aggressive in African American (AA) men when compared to European-American (EA) men. tends be a heterogeneous malignancy with complex biology that not fully understood. We use metabolomics as tool understand mechanisms behind progression disparities its clinical outcome. A key enzyme purine metabolic pathway, Adenosine deaminase (ADA) was found upregulated PCa. ADA...
PURPOSE Develop and validate gene expression–based biomarker associated with recurrent disease to facilitate risk stratification of clear cell renal carcinoma (ccRCC). MATERIALS AND METHODS We retrospectively identified 110 patients who underwent radical nephrectomy for ccRCC ( discovery cohort). Patients recurred were matched on the basis grade/stage without recurrence. Capture whole-transcriptome sequencing was performed RNA isolated from archival tissue using Illumina platform. developed...