A5077390820- Advanced biosensing and bioanalysis techniques
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Plant Gene Expression Analysis
- Plant nutrient uptake and metabolism
- Electrochemical Analysis and Applications
- CRISPR and Genetic Engineering
- Cryospheric studies and observations
- Conducting polymers and applications
- Electrochemical sensors and biosensors
- Cancer-related molecular mechanisms research
- Plant Stress Responses and Tolerance
- Geology and Paleoclimatology Research
- Biosensors and Analytical Detection
- Geological formations and processes
- Genetics, Aging, and Longevity in Model Organisms
- Plant tissue culture and regeneration
- Climate change and permafrost
- RNA modifications and cancer
- Calibration and Measurement Techniques
- Oceanographic and Atmospheric Processes
- Remote Sensing and Land Use
- Circular RNAs in diseases
- Optical Polarization and Ellipsometry
- Insect and Pesticide Research
Oak Ridge National Laboratory
2020-2025
Capital Normal University
2011-2024
Temasek Life Sciences Laboratory
2018-2022
National University of Singapore
2018-2022
North China University of Science and Technology
2020-2022
Wuhan University
2018-2022
Renmin Hospital of Wuhan University
2018-2022
Chongqing Medical University
2018-2021
Children's Hospital of Chongqing Medical University
2018-2021
Shenzhen Maternity and Child Healthcare Hospital
2021
Abstract Many eukaryotic transcription factors (TF) form homodimer or heterodimer complexes to regulate gene expression. Dimerization of BASIC LEUCINE ZIPPER (bZIP) TFs are critical for their functions, but the molecular mechanism underlying DNA binding and functional specificity homo- versus heterodimers remains elusive. To address this gap, we present double Affinity Purification-sequencing (dDAP-seq) technique that maps sites on endogenous genomic DNA. Using dDAP-seq profile twenty pairs...
Summary RNA plays a central role in plants, governing various cellular and physiological processes. Monitoring its dynamic abundance provides discerning understanding of molecular mechanisms underlying plant responses to internal (developmental) external (environmental) stimuli, paving the way for advances biotechnology engineer crops with improved resilience, quality productivity. In general, traditional methods analysis plants require destructive, labour‐intensive time‐consuming assays. To...
Abstract Plant lignocellulosic biomass, i.e. secondary cell walls of plants, is a vital alternative source for bioenergy. However, the acetylation xylan in impedes conversion biomass to biofuels. Previous studies have shown that REDUCED WALL ACETYLATION (RWA) proteins are directly involved but regulatory mechanism RWAs not fully understood. In this study, we demonstrate overexpression Populus trichocarpa PtRWA-C gene increases level and lignin content S/G ratio, ultimately yielding poplar...
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PHYTOCHROME INTERACTING FACTOR3 (PIF3) is an important component in the phytochrome signaling pathway and mediates plant responses to various environmental conditions. We found that PIF3 involved inhibition of root growth Arabidopsis thaliana seedlings induced by nitric oxide (NO) light. Overexpression partially alleviated inhibitory effect NO on growth, whereas pif3-1 mutant displayed enhanced sensitivity terms growth. During signaling, photoreceptor PHYB degradation PIF3. phyB-9 had a...
Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1), which displays a distinct long noncoding RNA (lncRNA) expression profile, has been defined as unique subgroup in the new classification of neoplasms. However, biological roles key lncRNAs development NPM1-mutated AML are currently unclear. Here, we aimed to investigate functional and mechanistic lncRNA HOTAIRM1 AML.The was analyzed public database further determined by qRT-PCR samples cell lines. The cause upregulated...
The mediator complex is highly conserved in eukgaryotes and integral for transcriptional responses. Mediator subunits associate with signal-responsive transcription factors (TF) to activate expression of specific genes. As the key TF Arabidopsis thaliana senescence, ORESARA1 (ORE1) required nitrogen deficiency (-N) induced senescence; however, subunit that associates ORE1 remains unknown. Here, we show MED19a -N senescence-responsive Disordered forms inducible nuclear condensates under...
Respective changes in functional and anatomical connectivities of default mode network (DMN) after antipsychotic treatment have been reported. However, alterations structure-function coupling remain unknown. We performed diffusion tensor imaging (DTI) resting-state magnetic resonance 42 drug-naive first-episode schizophrenia patients (FESP) both at baseline 8-weeks risperidone monotherapy, 38 healthy volunteers. Independent component analysis was used to assess voxel-wise DMN synchrony. A...
Summary Several SQUAMASA PROMOTER BINDING PROTEIN‐LIKE (SPL) transcription factors are involved in plant developmental transition from vegetative to reproductive growth. However, the function of SPL10 regulating floral is largely unknown. It also not known which Mediator subunit mediates transcriptional activity. Here, we used overexpression lines and knockout mutants examine role flowering‐time regulation investigated possible interactions with several mediator subunits vitro vivo . Plants...
Sensitivity and accuracy are both of great significance for immunosensors in practical application; thus, it is an effective strategy to improve the performance from above two aspects. Herein, we reported a multifunctional immunoprobe based on metal–organic framework 818 (MOF-818) that possessed dual catalytic activity enhance sensitivity immunosensors. In presence dopamine hydrogen peroxide, MOF-818 can accelerate oxidative polymerization couple biomolecules facilitate formation semiquinone...
Summary Plant establishment requires the formation and development of an extensive root system with architecture modulated by complex genetic networks. Here, we report identification PtrXB38 gene as expression quantitative trait loci (eQTL) hotspot, mapped using 390 leaf 444 xylem Populus trichocarpa transcriptomes. Among predicted targets this trans ‐eQTL were genes involved in plant hormone responses development. Overexpression led to significant increases callusing both stem‐born roots...
SUMMARY Terpenes play crucial roles in plant growth, development, and stress responses. The biosynthesis of terpenes is influenced by abiotic factors, such as drought, temperature, or light. However, the molecular network underlying how are regulated response to environmental stimuli remains largely unknown. Here, we identified autophagy protein SgATG8a a key mediator GABA‐regulated terpene production drought tolerance Sindora glabra . SgATG8a, evolutionarily related animal GABA...