A5101515813- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Congenital Heart Disease Studies
- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- Cardiovascular and Diving-Related Complications
- RNA modifications and cancer
- Fatigue and fracture mechanics
- Cardiomyopathy and Myosin Studies
- Medicinal Plants and Bioactive Compounds
- Calcium signaling and nucleotide metabolism
- Mitochondrial Function and Pathology
- Apelin-related biomedical research
- Fuel Cells and Related Materials
- Metabolism, Diabetes, and Cancer
- Circular RNAs in diseases
- Tracheal and airway disorders
- Coronary Artery Anomalies
- RNA and protein synthesis mechanisms
- Autophagy in Disease and Therapy
Shanghai Chest Hospital
2013-2021
Shanghai Jiao Tong University
2013-2021
The First People's Hospital of Wenling
2019
Air Force Medical University
2009
The cardiac transcription factor GATA4 is essential for development, and mutations in this gene have been implicated a wide variety of congenital heart diseases both animal models humans. However, whether mutated predisposes to dilated cardiomyopathy (DCM) remains unknown. In study, the whole coding region splice junction sites was sequenced 110 unrelated patients with idiopathic DCM. available relatives index patient harboring an identified mutation 200 ethnically matched healthy...
Dilated cardiomyopathy (DCM) is the most common form of primary myocardial disorder and associated with substantial morbidity mortality. Increasing evidence suggests that genetic risk factors play an important role in pathogenesis idiopathic DCM. However, DCM a genetically heterogeneous disease, defects responsible for overwhelming majority cases remain to be identified. In present study, entire coding region splice junction sites GATA4 gene, which encodes cardiac transcription factor...
Dilated cardiomyopathy (DCM) represents the most prevalent form of primary cardiomyopathy, and is common reason for heart transplantation a major cause congestive failure. Aggregating evidence demonstrates that genetic defects are associated with DCM, great number mutations in >50 genes have been linked to DCM. However, DCM genetically heterogeneous disorder components underpinning significant proportion patients remain unknown. In present study, coding exons flanking exon‑intron boundaries...
// Yingjia Xu 1 , Ritai Huang 2 Jianing Gu 3 and Weifeng Jiang Department of Cardiology, Shanghai Chest Hospital, Jiao Tong University, Shanghai, China Cardiothoracic Surgery, Ren Ji School Medicine, JiaoTong Rui Jin Correspondence to: Xu, email: Huang, Keywords : long non-coding RNAs (lncRNAs), atrial fibrillation (AF), transcription factors, Gerotarget Received September 13, 2015 Accepted February 05, 2016 Published 18, Abstract Atrial (AF) is a highly prevalent cardiac arrhythmia disease,...
TBX5 has been linked to Holt-Oram syndrome, with congenital heart defect (CHD) and atrial fibrillation (AF) being two major cardiac phenotypes. However, the prevalence of a variation in patients CHD AF remains obscure. In this research, by sequencing analysis 178 index both AF, novel heterozygous variation, NM_000192.3: c.577G>T; p.(Gly193*), was identified one patient as well bicuspid aortic valve (BAV), an allele frequency approximately 0.28%. Genetic proband's pedigree showed that...
Myocardial infarction (MI) is identified as the myocardial necrosis due to ischemia/reperfusion (I/R) injury and remains a leading cause of mortality. C1q/TNF-related protein 13 (CTRP13) member CTRP family that has been found be involved in coronary artery disease (CAD). However, role CTRP13 MI unclear. We aimed explore functional H9c2 cells exposed hypoxia/reoxygenation (H/R). Our results demonstrated H/R stimulation significantly decreased expression cells. H/R-induced an increase ROS...
Circular RNAs (circRNAs) are an emerging class of RNA species that may play a critical regulatory role in gene expression control, which can serve as diagnostic biomarkers for many diseases due to their abundant, stable, and cell- or tissue-specific expression. However, the association between circRNAs atrial fibrillation (AF) is still not clear. In this study, we used sequencing data identify quantify circRNAs. Differential analysis identified 250 up- 126 down-regulated AF subjects compared...
The purpose is to reveal the role and mechanism of long non-coding ribonucleic acid (lncRNA) in atrial fibrillation (AF) energy metabolism remodeling. healthy adult New Zealand rabbit was chosen as experimental animal, AF models were built. Besides, lncRNA sequencing method based on nano sensor technology employed detect differentially expressed lncRNAs, target its genes determined through bioinformatics analysis. Subsequently, TCONS_00016478 dysfunction experiment performed. gene level...