A5100395845- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Cardiac electrophysiology and arrhythmias
- Viral Infectious Diseases and Gene Expression in Insects
- Biosimilars and Bioanalytical Methods
- Viral-associated cancers and disorders
- Cardiac pacing and defibrillation studies
- CNS Lymphoma Diagnosis and Treatment
- Plant-Microbe Interactions and Immunity
- Chronic Lymphocytic Leukemia Research
- Plant Pathogens and Fungal Diseases
- Colorectal and Anal Carcinomas
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Surgical Treatments
- Healthcare and Venom Research
- T-cell and Retrovirus Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
Shanghai Jiao Tong University
2016-2025
Henan University of Science and Technology
2024-2025
Yunnan Agricultural University
2024-2025
Renji Hospital
2014-2024
First Affiliated Hospital of Zhengzhou University
2014-2024
Gansu University of Traditional Chinese Medicine
2022-2024
Hetao College
2024
Southern Medical University
2024
Sun Yat-sen University
2015-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2015-2024
Anti-CD20/CD3 T cell–dependent bispecific antibodies may be useful for the treatment of B cell malignancies.
Natural killer/T-cell lymphoma (NKTCL) is a rare subtype of non-Hodgkin that associated with poor outcome. Currently, the treatment needs NKTCL remain unmet, and efforts to further improve are urgently needed. Herein, seven patients who failed respond various types chemotherapies were treated anti-programmed death 1 (anti-PD-1) antibody pembrolizumab at 100 mg every 3 weeks. After median four cycles (range 2–18), out responded (two complete response, two partial overall response rate 57%)....
Abstract Purpose: Since CD7 may represent a potent target for T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) immunotherapy, this study aimed to investigate safety and efficacy of autologous CD7–chimeric antigen receptor (CAR) T cells in patients with relapsed refractory (R/R) T-ALL/LBL, as well its manufacturing feasibility. Patients Methods: Preclinical phase was conducted NPG mice injected Luc+ GFP+CCRF-CEM cells. Open-label I clinical trial (NCT04004637) enrolled R/R CD7-positive T-ALL/LBL...
Background: Circumferential pulmonary vein isolation (CPVI) alone or combined with adjuvant substrate modifications is unsatisfactory for atrial fibrillation (AF) control in nonparoxysmal AF patients. Ablation targeting the fibrotic areas after CPVI (STABLE-SR [Electrophysiological Substrate Left Atrium During Sinus Rhythm]) a newly evolved modification strategy. Methods and Results: In this multicenter, randomized clinical trial, 229 symptomatic patients were 1:1 to STABLE-SR group (n=114)...
Abstract Purpose: Optimal treatment strategies for advanced natural killer/T (NK/T)-cell lymphoma have not been fully defined. We compared the safety and efficacy of DDGP SMILE regimens NK/T-cell in a randomized controlled, multicenter, open-label clinical trial. Experimental Design: Patients were newly diagnosed stages III–IV had performance scores 0 to 2. Six cycles (dexamethasone, cisplatin, gemcitabline, pegaspargase) or methotrexate, ifosfamide, L-asparaginase, etoposide) chemotherapy...
We and others have previously shown that the STAT3 signaling pathway is activated in some esophageal squamous cell carcinoma (ESCC) cells required for survival growth of these primary ESCC-derived xenografts. It has also been natural polyphenol curcumin an effective anti-tumor agent.Luciferase assay immunoblotting were performed to examine whether suppressed signaling. CCK-8 xenografts utilized analyzing ESCC culture mice. Soft agar was carried out determine colony formation ability presence...
Importance Success rates of pulmonary vein isolation (PVI) are modest for persistent atrial fibrillation (AF). Additional linear ablation beyond PVI has not been proved superior to alone in randomized trials. Ethanol infusion the Marshall (EIVOM) facilitates at mitral isthmus and may lead improved effectiveness a strategy. Objective To determine whether with radiofrequency energy combined EIVOM added improves sinus rhythm maintenance compared patients AF. Design, Setting, Participants The...
The role of neoadjuvant chemotherapy (NAC) in colon cancer remains unclear. This trial investigated whether 3 months modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or capecitabine (CAPOX) as NAC could improve outcomes patients with locally advanced versus upfront surgery.
The use of chloroquine treatment for Plasmodium falciparum malaria was abandoned in China 1979 because widespread drug resistance. Subsequent studies found decreases the prevalence chloroquine-resistant strains. To evaluate these and assess current status sensitivity Hainan, China, we determined P. resistance transporter (PfCRT) 76T marker DNA blood samples collected from 1978 to 2001. Results showed presence PfCRT 101 112 (90%) 1981, 30 43 (70%) 1986, 22 34 (65%) 1997 1998, 37 68 (54%) thus...
Six1 is one of the transcription factors that act as master regulators development and are frequently dysregulated in cancers. However, role pancreatic cancer not clear. Here we show relative expression mRNA increased correlated with advanced tumor stage. In vitro functional assays demonstrate forced overexpression significantly enhances growth rate proliferation ability cells. Knockdown endogenous decreases these cells dramatically. Furthermore, promotes a xenograft assay. We also gene...
A retrospective study.To compare the radiographical and clinical outcomes between closing wedge osteotomy (CWO) closing-opening (COWO) for thoracolumbar kyphosis secondary to ankylosing spondylitis.Several surgical techniques have been used correct fixed caused by spondylitis. To date, comparison of CWO COWO has not yet addressed.According association with anterior edge opening or shown on postoperative radiographs, 64 patients were divided into 2 groups (35 in group 29 group). The compared...
<h3>Importance</h3> The L-asparaginase–based SMILE (dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide) chemotherapy regimen has shown higher response rates survival benefit over an anthracycline-containing regimen. However, the safety profile was not satisfied. A well-tolerated with promising efficacy is lacking. <h3>Objective</h3> To compare of DDGP cisplatin, gemcitabine, pegaspargase) in newly diagnosed advanced-stage (III/IV) extranodal natural killer/T-cell lymphoma...
Abstract Recently, erythropoietin (EPO) and the nonerythropoietic derivative asialoEPO have been linked to tissue protection in nervous system. In this study, we tested their effects a model of neonatal hypoxia‐ischemia (HI) 7‐day‐old rats (unilateral carotid ligation exposure 7.7% O 2 for 50 min). EPO (10 U/g body weight = 80 ng/g; n 24), (80 23) or vehicle (phosphate‐buffered saline with 0.1% human serum albumin; 24) was injected intraperitoneally 4 h before HI. Both drugs were protective,...
Aims Circumferential pulmonary vein isolation (CPVI) has been reported to account for 30% of atrial fibrillation (AF) recurrence after initial ablation, and (PV) re-connection accounts about 80% AF recurrence. There is no information in the literature whether early identification treatment acute PV conduction recovery during ablation an impact on subsequent clinical results. The objective investigate prevalence observation time paroxysmal AF, evaluate re-isolation
Pioglitazone, one of the peroxisome proliferator-activated receptor-gamma activators, possesses anti-inflammatory and antioxidant properties. In present study, we sought to identify impact pioglitazone on outcome catheter ablation for paroxysmal atrial fibrillation (PAF). We conducted a prospective observational cohort study 150 consecutive patients undergoing drug-refractory PAF. All had history type 2 diabetes mellitus (T2DM) were divided based whether they received before or not. After...
Bone marrow mesenchymal stem cells ( BMMSC ) have been shown to be recruited the tumor microenvironment and exert a tumor‐promoting effect in variety of cancers. However, molecular mechanisms related on head neck cancer HNC are not clear. In this study, we investigated Periostin POSTN its roles . vitro analysis cultured ‐conditioned media MSC ‐ CM showed that significantly promoted progression by enhancing cell proliferation, migration, epithelial‐mesenchymal transformation EMT ), altering...
Of diseases affecting maize (Zea mays), Fusarium graminearum is one of the most common pathogenic fungi that cause stalk rot. In present study, Trichoderma asperellum GDFS1009 strain was shown to be an effective biocontrol agent against a confrontation culture test, displayed approximately 60% inhibition rate on mycelial growth F. graminearum. pot trials, application 2 g/pot T. granules had best control effect rot at seedling stage (up 53.7%), while average plant height and fresh weight were...
Abstract Spontaneous bacterial peritonitis (SBP) is a common complication of liver cirrhosis. This study was performed to compare the microbiological characteristics nosocomial and community-acquired episodes in China. Five hundred seventy-five strains were isolated from ascitic fluid cirrhotic patients Beijing 302 Hospital January 2014 December 2014. The SBP (n = 264) 311) groups exhibited significant differences clinical symptoms (P < 0.01). In both groups, most bacteria Escherichia...