A5063436558- Intergenerational Family Dynamics and Caregiving
- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- Cancer-related molecular mechanisms research
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Pain Mechanisms and Treatments
- Pancreatic and Hepatic Oncology Research
- Lipid metabolism and disorders
- Liver Disease and Transplantation
- Global Health Care Issues
- Hepatitis C virus research
- Health disparities and outcomes
- Sepsis Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Testicular diseases and treatments
- Pain Management and Treatment
- Insurance, Mortality, Demography, Risk Management
- Liver Diseases and Immunity
- Heavy Metal Exposure and Toxicity
- Gallbladder and Bile Duct Disorders
- Innovation and Socioeconomic Development
- Inflammatory Biomarkers in Disease Prognosis
Zhujiang Hospital
2023-2025
Southern Medical University
2023-2025
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
Sun Yat-sen University
2018-2025
Zhongnan University of Economics and Law
2022-2023
Wuhan Institute of Bioengineering
2023
Sixth Affiliated Hospital of Sun Yat-sen University
2018-2020
National Natural Science Foundation of China
2019
Creative Commons
2019
U.S. National Science Foundation
2019
Alzheimer's disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms treatments remain elusive. Here we report therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model disease. Our findings reveal that treatment prevents memory decline 4-month-old mice motivation loss 14-month-old mice, accompanied restoration glial water channel aquaporin-4 polarity, improved brain drainage efficiency, reduction...
Adequate thickness of the endometrium has been well recognized as a critical factor for embryo implantation. This was prospective cohort study to investigate benefits platelet-rich plasma (PRP) women with thin who received frozen transfer (FET) program in larger number patients and explore underlying mechanism.In this study, we investigated effects PRP FET program. 64 (<7 mm) were recruited. intrauterine infusion given group during hormone replacement therapy (HRT) cycle cycles.After...
Background Previous studies have suggested the potential of PD-1/PD-L1 inhibitors in treatment chronic HBV infection. However, since phase III clinical trials not yet been announced, additional insights may be obtained by observing changes serum hepatitis B surface antigen (HBsAg) and HBV-DNA levels cancer patients undergoing PD-1 inhibitor therapy. Objective To explore effects combinational therapy on HBsAg levels, investigate incidence loss, reactivation (HBVr), immune-related adverse...
Abstract Background Hepatocellular carcinoma (HCC) is a common cancer and the leading cause persistent hepatitis B virus (HBV) infection. We aimed to identify some core genes pathways for HBV-related HCC. Methods Gene expression profiles of GSE62232, GSE121248, GSE94660 were available from Expression Omnibus (GEO). The GSE62232 GSE121248 analysis datasets was validation dataset. GEO2R online tool Venn diagram software applied analyze commonly differentially expressed between HCC tissues...
The deteriorating health status of widowed elderly individuals becomes an important restriction factor affecting healthy aging in China. This paper aimed to find effective ways reduce the risk disability among elderly.An empirical analysis was conducted by using four surveys from China Health and Retirement Longitudinal Study (CHARLS) 2011, 2013, 2015, 2018. A fixed-effects model performed estimate effect widowhood on its disparities different groups, influencing channels moderating effects...
Purpose: This study was conducted to explore the differences in functional changes pain matrix patients with chronic back (CBP) at different stages and identify whether these brain were related duration. Patients Methods: In this study, 29 healthy individuals 54 CBP recruited. According duration, 25 (3 12 months) divided into CBP-S group (≥ 24 CBP-L group. All subjects completed clinical pain-related measurement magnetic resonance imaging (fMRI) scans. Moreover, amplitude of low-frequency...
It is known that caregivers are more likely to be depressed compared those without caregiving burden. The disappearance of burden after widowhood may alleviate depression, but at the same time diminishment marital resources caused by exacerbate depression. So, what effect does have on depression among caregivers?, which was valuable for promoting mental health in context China's aging.China Health and Retirement Longitudinal Study (CHARLS), a longitudinal data, selected middle-aged elderly...
Despite accumulating evidence revealing that Glucose-6-phosphate dehydrogenase (G6PD) is highly expressed in many tumor tissues and plays a remarkable role cancer tumorigenesis progression, there still lack of G6PD pan-cancer analysis. This study was designed to analyze the expression status prognostic significance pan-cancer.G6PD data were obtained from multiple resources including Genotype-Tissue Expression, Cancer Genome Atlas, Tumor Immunity Estimation Resource. These used assess...
Primary biliary cholangitis-autoimmune hepatitis overlap syndrome (PBC-AIH OS), which exhibits features between autoimmune and cholestasis, is a common condition usually shows progressive course toward cirrhosis liver failure without adequate treatment. Synthesis of bile acids (BAs) plays an important role in injury the process regulated by fibroblast growth factor 19 (FGF19). The overall circulating FGF19 BA synthesis PBC-AIH OS requires further investigation.We analyzed correlated clinical...
Purpose Based on life course theories, health among older people is driven by a continuous and cumulative process that develops over the course. To better understand aging process, it important to assess associations between parity heart disease in of China. Method The prevalence number births, boys or girls ever born were evaluated 5,990 samples (mean age 64.1 years) using Probit regression model based data from China Health Retirement Longitudinal Study (CHARLS) conducted 2013 2018. was...
Abstract Background Medical reimbursement in China is not for all diseases, and medical expenses are completely consistent with service demand, though the scope proportion of gradually expanding. This study aimed to examine effect retirement on urban China. Methods The were estimated by using fuzzy regression discontinuity based data from Health Retirement Longitudinal Study (CHARLS) 2011, 2013, 2015, 2018. Its group heterogeneity educational backgrounds marital status, underlying mechanisms...
Background and AimsAlagille syndrome (AGS) is an autosomal dominant multisystem disorder caused by mutations in the JAG1 NOTCH2 genes. AGS has been rarely reported adult patients, mainly because its characteristics adults are subtle. The study aimed to improve understanding of a descriptive case series.
Objective To explore the effect of progestin-primed ovarian stimulation protocol (PPOS) on mural granulosa cells (GCs) apoptosis and hormonal profiles in follicular fluid (FF) efficacy over GnRH antagonist (GnRH-A) protocols.Methods We performed a prospective cohort study from June through August 2017 at tertiary teaching hospital. 63 Patients meeting our criteria were recruited this voluntarily stratified to PPOS or GnRH-A group randomly. Mural GCs FF collected during oocyte retrieval....
There is currently no single model for predicting Wilson's disease (WD). We aimed to create a nomogram using daily clinical parameters improve the accuracy of WD diagnosis in patients with abnormal liver function. Between July 2016 and December 2020, we identified 90 function who had homozygous or compound heterozygous mutations ATP7B gene. The control group included 128 similar but during same time period. To nomogram, screened potential predictive variables least absolute shrinkage...
Abstract Background : Despite emerging evidence linking blood cell indices (BCIs) to sepsis mortality, the inconsistency of observational studies obscures clarity these associations. This study aims clarify causal influence BCIs on 28-day mortality rates in patients. Methods Utilizing univariable and multivariable Mendelian randomization (MR) analyses, we examined impact by analyzing data from extensive genome-wide association studies. The inverse-variance weighted (IVW) method was our...
BACKGROUND The neutrophil-to-lymphocyte ratio (NLR) is commonly utilized as a prognostic indicator in end-stage liver disease (ESLD), encompassing conditions like failure and decompensated cirrhosis. Nevertheless, some studies have contested the value of NLR ESLD. AIM To investigate ability to predict METHODS Databases, such Embase, PubMed, Web Science, Cochrane Library, China National Knowledge Infrastructure, Weipu, Wanfang, were comprehensively searched identify published before October...
<title>Abstract</title> Neuropathic pain (NP) caused by nerve damage or diseases affects the quality of life patients. Analyzing differentially expressed genes (DEGs) can help researchers focus on key molecular in diseases. This study aims to explore relationship between Cathepsin S (CTSS) and perineuronal nets (PNNs). Dataset GSE18803 was used for bioinformatics analysis firstly. Next, changes CTSS PNNs spinal cord spared injury (SNI) rats were detected. Then, LPS activate HAPI cells,...
Abstract Background Despite emerging evidence linking blood cell indices (BCIs) to sepsis mortality, the inconsistency of observational studies obscures clarity these associations. This study aims clarify causal influence BCIs on 28-day mortality rates in patients. Methods Utilizing univariable and multivariable Mendelian randomization (MR) analyses, we examined impact by analyzing data from extensive genome-wide association studies. The inverse-variance weighted (IVW) method was our primary...
Abstract Background The prevalence of zinc deficiency is high in patients with chronic liver disease, but few studies have hitherto explored the relationship between serum level and hepatitis B virus (HBV)-related acute-on-chronic failure (ACLF). This study aimed to assess association infectious complications, model for end-stage disease (MELD) score HBV-related ACLF. Methods Patients ACLF from Department Infectious Diseases Third Affiliated Hospital Sun Yat-sen University (Guangzhou, China)...
Abstract Background： Hepatocellular carcinoma (HCC) is a common cancer and the leading cause persistent hepatitis B virus infection. We aimed to identify some core genes pathways for HBV-related HCC. Methods: Gene expression profiles of GSE62232, GSE121248, GSE94660 were available from Expression Omnibus. The GEO2R online tool Venn diagram software applied analyze commonly differentially expressed genes. Then functional enrichment analysis using Ontology (GO) Kyoto Encyclopedia Genome (KEGG)...
Abstract Background : Previous studies have shown that blockade of programmed cell death-1 (PD-1) or death- Ligand-1 (PD-L1) may improve anti-HBV responses in vitro and woodchuck models. However, clinical data was limited on the role PD-1 inhibitors patients with chronic HBV infection. We aimed to observe changes ofserum HBsAgand HBV-DNA levels cancer under inhibitor-based therapies identify risk factors associated HBsAg fluctuations reactivation (HBVr). Methods A retrospective study...