A5010909393- Asthma and respiratory diseases
- Pneumonia and Respiratory Infections
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Allergic Rhinitis and Sensitization
- Emergency and Acute Care Studies
- Child Nutrition and Water Access
- School Health and Nursing Education
- Respiratory and Cough-Related Research
- Hemoglobinopathies and Related Disorders
- Viral gastroenteritis research and epidemiology
- Air Quality and Health Impacts
- Food Allergy and Anaphylaxis Research
- Global Maternal and Child Health
- Energy and Environment Impacts
- Blood donation and transfusion practices
- Food Security and Health in Diverse Populations
- Child and Adolescent Health
- Mosquito-borne diseases and control
- Hepatitis Viruses Studies and Epidemiology
- Lipoproteins and Cardiovascular Health
- Insects and Parasite Interactions
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
Komfo Anokye Teaching Hospital
2004-2024
Kwame Nkrumah University of Science and Technology
2008-2024
Kwame Nkrumah University
2022-2023
World Health Organization - Pakistan
2022
World Health Organization
2022
SUNY Upstate Medical University
2019-2020
East Tennessee State University
2018
University of Cambridge
2006
NHS Blood and Transplant
2006
GTx (United States)
2006
Dyslipidemia is a modifiable risk factor for cardiovascular disease (CVD). We investigated the prevalence and associated factors of dyslipidemia- raised total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), low high-density (HDL-C), non-high-density (non-HDL-C) in rural urban China.We analyzed data from 136,945 participants aged 40-100 years CNSSPP project 2014. was defined by NCEP-ATP III 2016 Chinese guidelines management dyslipidemia adults. Complete on demographic,...
The gut microbiota may be important in the postnatal development of immune system and hence influence prevalence atopic diseases. Bifidobacteria are most numerous bacteria guts infants, presence or absence certain species could determining geographic incidence We compared fecal populations bifidobacteria from children aged 25 to 35 days Ghana (which has a low atopy), New Zealand, United Kingdom (high-prevalence countries). Natal origin influenced detection bifidobacterial that samples almost...
Asthma and allergic diseases have increased in the developed countries. It is important to determine whether same trends are occurring developing countries Africa. We aimed time trend prevalence of exercise-induced bronchospasm (EIB) atopic sensitisation over a ten-year period Ghanaian schoolchildren.Two surveys conducted using methodology ten years apart (1993 2003) among schoolchildren aged 9-16 attending urban rich (UR), poor (UP), rural (R) schools. Exercise provocation consisted free...
Questionnaires are widely used in epidemiological studies to measure eczema symptom prevalence, but there concerns regarding their accuracy if as a diagnostic tool.To compare the performance of validated questionnaire and standardized skin examination protocol employed second phase International Study Asthma Allergies Childhood (ISAAC).A total 30,358 schoolchildren aged 8-12 years from 18 countries were examined for flexural eczema. Parents also completed an questionnaire. We compared...
Background: Neonatal illness is a leading cause of death worldwide; sepsis one the main contributors. The etiologies community-acquired neonatal bacteremia in developing countries have not been well characterized. Methods: Infants <2 months age brought with to selected health facilities Bangladesh, Bolivia, Ghana, India, Pakistan and South Africa were evaluated, blood cultures taken if they considered ill enough be admitted hospital. Organisms isolated using standard culture techniques....
Summary Objective A recent randomized clinical trial demonstrated home‐based treatment of WHO‐defined severe pneumonia with oral amoxicillin was equivalent to hospital‐based therapy and parenteral antibiotics. We aimed determine whether this finding is generalizable across four countries. Methods Multicentre observational study in Bangladesh, Egypt, Ghana Vietnam between November 2005 May 2008. Children aged 3–59 months were enrolled at participating health centres managed home (80–90 mg/kg...
Air pollution is the second largest risk to health in Africa, and children with asthma are particularly susceptible its effects. Yet, there a scarcity of air exposure data from cities sub-Saharan Africa. We aimed identify potential reduction strategies for school living urban areas
Summary Background Reports from several African countries have noted an increasing prevalence of asthma in areas extensive urbanization. Objective To investigate the relevance allergen‐specific sensitization and body mass index (BMI) to asthma/wheezing exercise‐induced bronchospasm (EIB) among children affluent poorer communities within a large town Ghana. Methods Children with physician‐diagnosed and/or current wheezing aged 9–16 years ( n =99; cases) three schools differing socio‐economic...
Introduction Existing risk assessment tools to identify children at of hospitalised pneumonia-related mortality have shown suboptimal discriminatory value during external validation. Our objective was derive and validate a novel tool aged 2–59 months across various settings. Methods We used primary, baseline, patient-level data from 11 studies, including evaluated for pneumonia in 20 low-income middle-income countries. Patients with complete were included logistic regression model assess the...
ObjectivesWe determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratification and chest-indrawing in-hospital factors.MethodsWe report characteristics pneumonia-related of children aged 2-59 months who were included Pneumonia Research Partnership to Assess WHO Recommendations dataset. We developed multivariable logistic regression models identify factors.ResultsAmong 285,839 children, 164,244 (57.5%) from hospital-based studies included. case fatality (CFR) without...
Stunting affects 26.7% of children worldwide, and little is known about its effects on the outcomes childhood pneumonia. We evaluated effect stunting pneumonia among enrolled in two large clinical trials.
Abstract Background Chronic lung diseases (CLDs), responsible for 4 million deaths globally every year, are increasingly important in low- and middle-income countries where most of the global mortality due to CLDs currently occurs. As existing health systems resource-poor contexts, especially sub-Saharan Africa (SSA), not generally oriented provide quality care chronic diseases, a first step re-imagining them is critically consider readiness service delivery across all aspects system....
The prevalence of chloroquine-resistant Plasmodium falciparum malaria has been increasing in sub-Saharan Africa and parts South America over the last 2 decades, associated with increased anaemia-associated morbidity higher mortality rates. Prospectively collected clinical parasitological data from a multicentre study 788 children aged 6–59 months uncomplicated P. were analysed order to identify risk factors for chloroquine treatment failure assess its impact on anaemia after therapy....
The epidemiology of West Nile virus (WNV) in Ghana, sub-Saharan Africa, and its relevance to transfusion were newly assessed. A total 1324 plasma samples from five Ghanaian populations, including 529 children (<6 y old, pre-transfusion) 795 adults (236 blood donors, 226 HIV-infected or non-infected pregnant women, 203 HIV symptomatic patients, 130 AIDS patients) screened for WNV RNA. No RNA was detected, but 4.8% (13/271) 27.9% (127/455) carried specific IgG adults, respectively, 2.4%...
Introduction Little is known about asthma control in the rising number of African children who suffer from this condition. The Achieving Control Asthma Children Africa (ACACIA) study an observational collecting evidence paediatric urban areas Ghana, Malawi, Nigeria, South Africa, Uganda and Zimbabwe. primary objectives are: (1) to identify 3000 aged between 12 years 14 with symptoms; (2) assess their control, current treatment, knowledge attitudes barriers achieving good control. Secondary...
BACKGROUND: Human erythrovirus (parvovirus) B19 is transmitted by transfusion of blood, blood components, and plasma derivatives resistant to most viral inactivation methods. genotype 3 prevalent in Ghana, no related clinical information available. STUDY DESIGN AND METHODS: This study assessed the transmission potential effect transfused antibodies viremic recipients. Immunological aspects infection children mainly for acute malarial anemia were examined. Molecular serologic methods adapted...
Abstract Rationale Bronchial responsiveness is an objectively measurable trait related to asthma. Its prevalence and association with asthma symptoms among children in many countries are unknown. Objectives To investigate international variations bronchial (BR) their associations atopic sensitization. Methods challenge tests were conducted 6,826 schoolchildren (aged 8–12 years) 16 using hypertonic (4.5%) saline. FEV 1 was measured at baseline after inhalation for 0.5, 1, 2, 4, 8 min. BR...
Exercise‐induced bronchospasm (EIB) is widely used in epidemiological studies to investigate the prevalence of asthma. We aimed determine seasonal variations EIB Ghanaian school children from urban‐rich (UR), urban‐poor (UP), and rural (R) schools. have previously reported 9–16‐year‐old be 3.1% dry season, with UR having a significantly higher both atopy compared UP or R children. In current study, was assessed same 1,095 wet season (5 months following initial study) using methodology....