A5004151061- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Vasculitis and related conditions
- interferon and immune responses
- Renal Diseases and Glomerulopathies
- Adolescent and Pediatric Healthcare
- Complement system in diseases
- Ocular Diseases and Behçet’s Syndrome
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Child and Adolescent Health
- Parathyroid Disorders and Treatments
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Rheumatoid Arthritis Research and Therapies
- Eosinophilic Disorders and Syndromes
- Streptococcal Infections and Treatments
- Kawasaki Disease and Coronary Complications
- COVID-19 Impact on Reproduction
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Pathogenesis and Treatment of Hiccups
- Connective tissue disorders research
- Inflammatory Myopathies and Dermatomyositis
Cukurova University
2017-2025
Kocaeli Üniversitesi
2023-2024
Université de Bordeaux
2024
Universitat Politècnica de València
2024
Kocaeli Sağlık ve Teknoloji Üniversitesi
2024
Kayseri Eğitim ve Araştırma Hastanesi
2022-2023
Center for Rheumatology
2018
Objectives: Henoch Schönlein Purpura (HSP) is the most common systemic vasculitis in childhood. We aimed to evaluate clinical features, seasonal variation, treatment outcomes and possible predicting factors related outcome among a large cohort of pediatric HSP patients. Methods: conducted medical record review study between July 2016 January 2019 evaluated manifestations potential risk for severe gastrointestinal (GI) involvement, biopsy-proven nephritis relapses. Results: The included 420...
Aberrant activation of the stimulator interferon genes (STING) pathway is a hallmark autoinflammatory disorders such as STING-associated vasculopathy with onset in infancy (SAVI), characterized by systemic inflammation affecting blood vessels, skin, and lungs. Despite its clinical significance, mechanisms linking STING to disease pathology remain poorly defined. In this study, we demonstrated that SAVI mice harboring N153S mutation exhibit diverse phenotypes, subset developing severe colitis...
Objectives: Henoch Schönlein Purpura (HSP) is the most common systemic vasculitis of childhood and often has a self-limiting course. We aimed to study whether practical laboratory parameters at diagnosis predict disease course including recurrence nephritis in addition severe gastrointestinal involvement children with HSP. Methods: This retrospective cohort included 214 HSP patients, 43.5% (n = 93) female 56.5% =121) male, who were diagnosed our department. Laboratory before treatment,...
Deficiency of adenosine deaminase 2 (DADA2) is a rare autoinflammatory disease that was firstly described in patients with early-onset strokes, livedo reticularis, and periodic fever resembling polyarteritis nodosa. In reported case series, researchers highly variable manifestations, including autoimmunity, immunodeficiency, hepatosplenomegaly, pancytopenia, ichthyosiform rash, arthritis, DADA2. A thirteen-year-old female patient who born to consanguineous parents admitted our hospital...
Introduction Multiple sclerosis (MS) is a chronic and autoimmune disease that has significant influence on the central nervous system, such as brain spinal cord, affecting millions of individuals globally. Understanding connection between subcortical regions MS crucial for effective diagnostic therapeutic approaches treating this disabling disease. This study explores relationship volume contours asymmetry index in with using volBrain software (https://www.volbrain.net; developed by José V....
Henoch-Schönlein purpura (HSP) is characterized by non-thrombocytopenic palpable purpura, abdominal pain, and arthralgia/arthritis. We aimed to describe the clinical presentations of children with HSP in a single center compare prevalence each manifestations between patients MEFV variants, particularly exon 10 those without.This cohort retrospectively included 144 (59 females, 85 males) without Familial Mediterranean Fever (FMF) symptoms followed for at least 6 months. utilized gene...
Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome, caused by biallelic pathogenic mutations in the <i>PRG4</i> gene, is characterized early-onset camptodactyly, noninflammatory arthropathy, coxa vara deformity, and rarely, pericardial effusion. Herein, we report 3 patients with CACP syndrome from 2 unrelated families. All are female, born to consanguineous parents, had camptodactyly since first years of their lives. Two a prior diagnosis juvenile idiopathic...
Familial Mediterranean fever (FMF) is the most common autoinflammatory disease and characterized by recurrent serositis episodes. We aimed to share our 20-year FMF experience, clarify a phenotype-genotype correlation, compare characteristics outcomes of pediatric patients over last 2 decades in this study.This medical record review study included 714 (340 females, 374 males), diagnosed Tel Hashomer diagnostic criteria between January 2009 2019 followed up department. Demographic...
Inactivating autosomal recessive mutations in fibroblast growth factor 23 (FGF23), klotho (KL) and polypeptide N-acetylgalactosaminotransferase 3 (GALNT3) genes lead to a rare disorder, hyperphosphatemic familial tumoral calcinosis (HFTC). Patients with HFTC present hyperphosphatemia tumor like soft tissue calcifications. Although 78% of patients develop their first symptoms between the ages 2-13 years, diagnosis is usually delayed until adulthood. Some individuals same genetic defect...
Familial Mediterranean fever (FMF) is characterized by recurrent, self-limiting attacks of and serositis. Nutrition very important in the management chronic diseases. Previous studies suggested that salty fatty diet cause inflammation, therefore we aimed to investigate effects dietary self-efficacy behavior about low-salt or low-fat on disease course children with FMF.This cross-sectional study included patients aged between 10-18 years, diagnosed our department admitted June 2019 September...
Background Coronaviruses have been the cause of 3 major outbreaks during last 2 decades. Information on coronavirus diseases in pregnant women is limited, and even less known about seriously ill women. Data are also lacking regarding real burden disease 2019 (COVID-19) infection from low/middle-income countries. The aim this study was to determine characteristics clinical course COVID-19 pregnant/puerperal admitted ICUs Turkey. Methods This a national, multicenter, retrospective study....
Introduction Henoch Schönlein purpura is characterised by palpable purpura, abdominal pain, arthritis/arthralgia, often with a self-limiting course. Herein, we report patient recurrent and severe gastrointestinal involvement, successfully treated methotrexate. Case presentation A 12-year-old boy was admitted to our department pain arthralgia. Since complaints were severe, systemic steroids administered, tapering of dosage. recurred several times maelena during next two months. Colchicine...
Objectives Behcet Disease (BD) is a systemic vasculitis, first described with triad of oral aphthous ulcers, genital and uveitis. The authors aimed to share the clinical properties utilities three distinct classification criteria for BD in this study.Methods This case–control study was conducted pediatric patients, diagnosed between January 2012 July 2019. control group included 53 children other rheumatic disorders. Sensitivity specificity International Study Group (ISG), Criteria (ICBD),...
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by malar rash, oral ulcers, arthralgia, photosensitivity and nephritis. Herein, we report a rare comorbidity, multiple avascular necrosis (AVN), in adolescent SLE patient also highlight the importance of risk factors for this comorbidity with brief literature review. A 13-year-old female was admitted severe headache, visual plus auditory hallucinations, polyarthritis history recurrent ulcers. Acneiform arthritis,...
Deficiency of Adenosine Deaminase 2 (DADA2) is a monogenic autoinflammatory disorder characterized by livedo reticularis, skin ulcers, subcutaneous rash, aphthous and leukocytoclastic vasculitis, neurological signs such as early onset stroke polyneuropathy. A minority DADA2 patients suffer from severe cytopenia lymphoproliferation. Herein, we report an adolescent patient, followed up having hematological for many years, eventually diagnosed DADA2. In view the presence elevated acute phase...